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Entry version 153 (10 Apr 2019)
Sequence version 2 (27 Jul 2011)
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Protein

Lymphocyte antigen 75

Gene

Ly75

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • carbohydrate binding Source: UniProtKB-KW
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptor
Biological processEndocytosis
LigandLectin

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Lymphocyte antigen 75
Short name:
Ly-75
Alternative name(s):
DEC-205
CD_antigen: CD205
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Ly75
Synonyms:Cd205
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:106662 Ly75

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini28 – 1667ExtracellularSequence analysisAdd BLAST1640
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1668 – 1692HelicalSequence analysisAdd BLAST25
Topological domaini1693 – 1723CytoplasmicSequence analysisAdd BLAST31

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 272 PublicationsAdd BLAST27
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001755428 – 1723Lymphocyte antigen 75Add BLAST1696

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi135N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi169 ↔ 194By similarity
Disulfide bondi183 ↔ 209By similarity
Disulfide bondi247 ↔ 340By similarity
Disulfide bondi317 ↔ 332By similarity
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi389 ↔ 485By similarity
Disulfide bondi462 ↔ 477By similarity
Glycosylationi529N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi597 ↔ 614By similarity
Disulfide bondi678 ↔ 790By similarity
Disulfide bondi752 ↔ 782By similarity
Glycosylationi843N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi865N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei934PhosphotyrosineBy similarity1
Glycosylationi935N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1061 ↔ 1081By similarity
Glycosylationi1077N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi1104N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi1198 ↔ 1212By similarity
Glycosylationi1226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1321N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1393N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1489 ↔ 1503By similarity
Glycosylationi1594N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1627N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1636 ↔ 1651By similarity
Modified residuei1704PhosphoserineCombined sources1
Modified residuei1720PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.4 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q60767

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q60767

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q60767

PeptideAtlas

More...
PeptideAtlasi
Q60767

PRoteomics IDEntifications database

More...
PRIDEi
Q60767

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q60767

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q60767

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in dendritic and thymic epithelial cells and lymph nodes.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000026980 Expressed in 151 organ(s), highest expression level in brain blood vessel

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q60767 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q60767, 1 interactor

Molecular INTeraction database

More...
MINTi
Q60767

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000108152

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q60767

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q60767

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini33 – 182Ricin B-type lectinPROSITE-ProRule annotationAdd BLAST150
Domaini164 – 211Fibronectin type-IIPROSITE-ProRule annotationAdd BLAST48
Domaini225 – 341C-type lectin 1PROSITE-ProRule annotationAdd BLAST117
Domaini368 – 486C-type lectin 2PROSITE-ProRule annotationAdd BLAST119
Domaini493 – 625C-type lectin 3PROSITE-ProRule annotationAdd BLAST133
Domaini652 – 791C-type lectin 4PROSITE-ProRule annotationAdd BLAST140
Domaini959 – 1092C-type lectin 5PROSITE-ProRule annotationAdd BLAST134
Domaini1111 – 1223C-type lectin 6PROSITE-ProRule annotationAdd BLAST113
Domaini1252 – 1375C-type lectin 7PROSITE-ProRule annotationAdd BLAST124
Domaini1402 – 1514C-type lectin 8PROSITE-ProRule annotationAdd BLAST113
Domaini1543 – 1662C-type lectin 9PROSITE-ProRule annotationAdd BLAST120

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297 Eukaryota
ENOG410XPJ1 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00950000182821

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000232050

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG045579

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q60767

KEGG Orthology (KO)

More...
KOi
K06559

Database of Orthologous Groups

More...
OrthoDBi
29241at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062 FN2, 1 hit
cd00161 RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 9 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034 CLECT, 10 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 10 hits
SSF57440 SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 2 hits
PS50041 C_TYPE_LECTIN_2, 9 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q60767-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRTGRVTPGL AAGLLLLLLR SFGLVEPSES SGNDPFTIVH ENTGKCIQPL
60 70 80 90 100
SDWVVAQDCS GTNNMLWKWV SQHRLFHLES QKCLGLDITK ATDNLRMFSC
110 120 130 140 150
DSTVMLWWKC EHHSLYTAAQ YRLALKDGYA VANTNTSDVW KKGGSEENLC
160 170 180 190 200
AQPYHEIYTR DGNSYGRPCE FPFLIGETWY HDCIHDEDHS GPWCATTLSY
210 220 230 240 250
EYDQKWGICL LPESGCEGNW EKNEQIGSCY QFNNQEILSW KEAYVSCQNQ
260 270 280 290 300
GADLLSIHSA AELAYITGKE DIARLVWLGL NQLYSARGWE WSDFRPLKFL
310 320 330 340 350
NWDPGTPVAP VIGGSSCARM DTESGLWQSV SCESQQPYVC KKPLNNTLEL
360 370 380 390 400
PDVWTYTDTH CHVGWLPNNG FCYLLANESS SWDAAHLKCK AFGADLISMH
410 420 430 440 450
SLADVEVVVT KLHNGDVKKE IWTGLKNTNS PALFQWSDGT EVTLTYWNEN
460 470 480 490 500
EPSVPFNKTP NCVSYLGKLG QWKVQSCEKK LRYVCKKKGE ITKDAESDKL
510 520 530 540 550
CPPDEGWKRH GETCYKIYEK EAPFGTNCNL TITSRFEQEF LNYMMKNYDK
560 570 580 590 600
SLRKYFWTGL RDPDSRGEYS WAVAQGVKQA VTFSNWNFLE PASPGGCVAM
610 620 630 640 650
STGKTLGKWE VKNCRSFRAL SICKKVSEPQ EPEEAAPKPD DPCPEGWHTF
660 670 680 690 700
PSSLSCYKVF HIERIVRKRN WEEAERFCQA LGAHLPSFSR REEIKDFVHL
710 720 730 740 750
LKDQFSGQRW LWIGLNKRSP DLQGSWQWSD RTPVSAVMME PEFQQDFDIR
760 770 780 790 800
DCAAIKVLDV PWRRVWHLYE DKDYAYWKPF ACDAKLEWVC QIPKGSTPQM
810 820 830 840 850
PDWYNPERTG IHGPPVIIEG SEYWFVADPH LNYEEAVLYC ASNHSFLATI
860 870 880 890 900
TSFTGLKAIK NKLANISGEE QKWWVKTSEN PIDRYFLGSR RRLWHHFPMT
910 920 930 940 950
FGDECLHMSA KTWLVDLSKR ADCNAKLPFI CERYNVSSLE KYSPDPAAKV
960 970 980 990 1000
QCTEKWIPFQ NKCFLKVNSG PVTFSQASGI CHSYGGTLPS VLSRGEQDFI
1010 1020 1030 1040 1050
ISLLPEMEAS LWIGLRWTAY ERINRWTDNR ELTYSNFHPL LVGRRLSIPT
1060 1070 1080 1090 1100
NFFDDESHFH CALILNLKKS PLTGTWNFTS CSERHSLSLC QKYSETEDGQ
1110 1120 1130 1140 1150
PWENTSKTVK YLNNLYKIIS KPLTWHGALK ECMKEKMRLV SITDPYQQAF
1160 1170 1180 1190 1200
LAVQATLRNS SFWIGLSSQD DELNFGWSDG KRLQFSNWAG SNEQLDDCVI
1210 1220 1230 1240 1250
LDTDGFWKTA DCDDNQPGAI CYYPGNETEE EVRALDTAKC PSPVQSTPWI
1260 1270 1280 1290 1300
PFQNSCYNFM ITNNRHKTVT PEEVQSTCEK LHSKAHSLSI RNEEENTFVV
1310 1320 1330 1340 1350
EQLLYFNYIA SWVMLGITYE NNSLMWFDKT ALSYTHWRTG RPTVKNGKFL
1360 1370 1380 1390 1400
AGLSTDGFWD IQSFNVIEET LHFYQHSISA CKIEMVDYED KHNGTLPQFI
1410 1420 1430 1440 1450
PYKDGVYSVI QKKVTWYEAL NACSQSGGEL ASVHNPNGKL FLEDIVNRDG
1460 1470 1480 1490 1500
FPLWVGLSSH DGSESSFEWS DGRAFDYVPW QSLQSPGDCV VLYPKGIWRR
1510 1520 1530 1540 1550
EKCLSVKDGA ICYKPTKDKK LIFHVKSSKC PVAKRDGPQW VQYGGHCYAS
1560 1570 1580 1590 1600
DQVLHSFSEA KQVCQELDHS ATVVTIADEN ENKFVSRLMR ENYNITMRVW
1610 1620 1630 1640 1650
LGLSQHSLDQ SWSWLDGLDV TFVKWENKTK DGDGKCSILI ASNETWRKVH
1660 1670 1680 1690 1700
CSRGYARAVC KIPLSPDYTG IAILFAVLCL LGLISLAIWF LLQRSHIRWT
1710 1720
GFSSVRYEHG TNEDEVMLPS FHD
Length:1,723
Mass (Da):197,352
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5FACCFE712C08B1C
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A2AW86A2AW86_MOUSE
Lymphocyte antigen 75
Ly75
1,723Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti51S → F AA sequence (PubMed:7553896).Curated1
Sequence conflicti1283S → P in AAA80215 (PubMed:7753172).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U19271 mRNA Translation: AAA80215.1
AF395445 mRNA Translation: AAK81722.1
AK049301 mRNA Translation: BAC33668.1
BC150734 mRNA Translation: AAI50735.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS38126.1

Protein sequence database of the Protein Information Resource

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PIRi
S58880

NCBI Reference Sequences

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RefSeqi
NP_038853.2, NM_013825.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Mm.2074

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000028362; ENSMUSP00000028362; ENSMUSG00000026980

Database of genes from NCBI RefSeq genomes

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GeneIDi
17076

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:17076

UCSC genome browser

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UCSCi
uc008jud.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Functional Glycomics Gateway - Glycan Binding

DEC-205

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19271 mRNA Translation: AAA80215.1
AF395445 mRNA Translation: AAK81722.1
AK049301 mRNA Translation: BAC33668.1
BC150734 mRNA Translation: AAI50735.1
CCDSiCCDS38126.1
PIRiS58880
RefSeqiNP_038853.2, NM_013825.3
UniGeneiMm.2074

3D structure databases

ProteinModelPortaliQ60767
SMRiQ60767
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ60767, 1 interactor
MINTiQ60767
STRINGi10090.ENSMUSP00000108152

PTM databases

iPTMnetiQ60767
PhosphoSitePlusiQ60767

Proteomic databases

EPDiQ60767
MaxQBiQ60767
PaxDbiQ60767
PeptideAtlasiQ60767
PRIDEiQ60767

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028362; ENSMUSP00000028362; ENSMUSG00000026980
GeneIDi17076
KEGGimmu:17076
UCSCiuc008jud.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
4065
MGIiMGI:106662 Ly75

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00950000182821
HOGENOMiHOG000232050
HOVERGENiHBG045579
InParanoidiQ60767
KOiK06559
OrthoDBi29241at2759

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q60767

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000026980 Expressed in 151 organ(s), highest expression level in brain blood vessel
ExpressionAtlasiQ60767 baseline and differential

Family and domain databases

CDDicd00062 FN2, 1 hit
cd00161 RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 10 hits
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
IPR000562 FN_type2_dom
IPR036943 FN_type2_sf
IPR013806 Kringle-like
IPR035992 Ricin_B-like_lectins
IPR000772 Ricin_B_lectin
PfamiView protein in Pfam
PF00040 fn2, 1 hit
PF00059 Lectin_C, 9 hits
SMARTiView protein in SMART
SM00034 CLECT, 10 hits
SM00059 FN2, 1 hit
SM00458 RICIN, 1 hit
SUPFAMiSSF50370 SSF50370, 1 hit
SSF56436 SSF56436, 10 hits
SSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 2 hits
PS50041 C_TYPE_LECTIN_2, 9 hits
PS00023 FN2_1, 1 hit
PS51092 FN2_2, 1 hit
PS50231 RICIN_B_LECTIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLY75_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60767
Secondary accession number(s): B2RWW5
, Q8C7T3, Q91XL8, Q9QUZ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: July 27, 2011
Last modified: April 10, 2019
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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