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UniProtKB - Q60766 (IRGM1_MOUSE)

Entry version 135 (16 Jan 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Immunity-related GTPase family M protein 1

Gene

Irgm1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion.9 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi84 – 91GTPBy similarity8
Nucleotide bindingi109 – 113GTPBy similarity5
Nucleotide bindingi191 – 193GTPBy similarity3
Nucleotide bindingi232 – 234GTPBy similarity3

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
Biological processAutophagy, Immunity, Innate immunity
LigandGTP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Immunity-related GTPase family M protein 1 (EC:3.6.5.-)
Alternative name(s):
Interferon-inducible GTPase 3
Interferon-inducible protein 1
LPS-stimulated RAW 264.7 macrophage protein 47
Short name:
LRG-47
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Irgm1
Synonyms:Ifi1, Iigp3, Irgm
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107567 Irgm1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice do not show obvious abnormalities except a loss of resistance to infection by S.typhimurium, T.cruzi, T.gondii, L.monocytogenes and M.tuberculosis. Upon infection, alterations of blood elements occur including lymphopenia, anemia, and thrombocytopenia.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi90S → N: Loss of targeting to plasma membrane and phagosomes. 1 Publication1
Mutagenesisi356C → A: No effect on subcellular location. 1 Publication1
Mutagenesisi358I → A: No effect on subcellular location. 1 Publication1
Mutagenesisi359V → A: No effect on subcellular location. 1 Publication1
Mutagenesisi360N → A: No effect on subcellular location. Abolishes Golgi and lysosomal localization; when associated with A-364. 1
Mutagenesisi362F → A: No effect on subcellular location. 1 Publication1
Mutagenesisi362F → EF: Disrupts amphipathicity and abolishes Golgi localization; when associated with Glu-367. 1 Publication1
Mutagenesisi363F → A: No effect on subcellular location. 1 Publication1
Mutagenesisi364R → A: No effect on subcellular location. Abolishes Golgi and lysosomal localization; when associated with A-360 or A-367. 1
Mutagenesisi365L → A: No effect on subcellular location. 1 Publication1
Mutagenesisi366L → A: No effect on subcellular location. 1 Publication1
Mutagenesisi367R → A: No effect on subcellular location. Abolishes Golgi and lysosomal localization; when associated with A-364. 1
Mutagenesisi367R → ER: Disrupts amphipathicity and abolishes Golgi localization; when associated with Glu-362. 1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003257501 – 409Immunity-related GTPase family M protein 1Add BLAST409

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei202PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q60766

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q60766

PeptideAtlas

More...PeptideAtlasi		Q60766

PRoteomics IDEntifications database

More...PRIDEi		Q60766

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q60766

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q60766

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q60766

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in lung and primary macrophages.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated by LPS and IFNG (at protein level). Up-regulated upon infection by various pathogens including T.cruzi, T.gondii, L.monocytogenes, M.tuberculosis and murine cytomegalovirus.7 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000046879 Expressed in 215 organ(s), highest expression level in submandibular gland

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q60766 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q60766 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		200520, 1 interactor

Protein interaction database and analysis system

More...IntActi		Q60766, 2 interactors

Molecular INTeraction database

More...MINTi		Q60766

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000050446

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q60766

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q60766

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini75 – 251IRG-type GAdd BLAST177

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 289Mediates targeting to cell membrane and phagosomesAdd BLAST215
Regioni350 – 374Mediates targeting to the GolgiAdd BLAST25

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410J94V Eukaryota
ENOG4111A9F LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153722

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG101048

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q60766

KEGG Orthology (KO)

More...KOi		K14139

Database of Orthologous Groups

More...OrthoDBi		688334at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q60766

TreeFam database of animal gene trees

More...TreeFami		TF331897

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR030385 G_IRG_dom
IPR007743 Immunity-related_GTPase-like
IPR027417 P-loop_NTPase

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05049 IIGP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540 SSF52540, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51716 G_IRG, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60766-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKPSHSSCEA APLLPNMAET HYAPLSSAFP FVTSYQTGSS RLPEVSRSTE 
        60         70         80         90        100
RALREGKLLE LVYGIKETVA TLSQIPVSIF VTGDSGNGMS SFINALRVIG 
       110        120        130        140        150
HDEDASAPTG VVRTTKTRTE YSSSHFPNVV LWDLPGLGAT AQTVEDYVEE 
       160        170        180        190        200
MKFSTCDLFI IIASEQFSSN HVKLSKIIQS MGKRFYIVWT KLDRDLSTSV 
       210        220        230        240        250
LSEVRLLQNI QENIRENLQK EKVKYPPVFL VSSLDPLLYD FPKLRDTLHK 
       260        270        280        290        300
DLSNIRCCEP LKTLYGTYEK IVGDKVAVWK QRIANESLKN SLGVRDDDNM 
       310        320        330        340        350
GECLKVYRLI FGVDDESVQQ VAQSMGTVVM EYKDNMKSQN FYTLRREDWK 
       360        370        380        390        400
LRLMTCAIVN AFFRLLRFLP CVCCCLRRLR HKRMLFLVAQ DTKNILEKIL 

RDSIFPPQI
Length:409
Mass (Da):46,552
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE4913367193059B6
GO
Isoform 2 (identifier: Q60766-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Show »
Length:393
Mass (Da):44,888
Checksum:iAA29EED4F483B044
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J7NUP1J7NUP1_MOUSE
Immunity-related GTPase family M pr...
Irgm1 Ifggd3, Irgm, mCG_19410
393Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti151M → V in BAE39622 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0323841 – 16Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U19119 mRNA Translation: AAB48942.1
AK002545 mRNA Translation: BAB22176.1
AK167558 mRNA Translation: BAE39622.1
AK171743 mRNA Translation: BAE42645.1
AL645849 Genomic DNA No translation available.
BC145957 mRNA Translation: AAI45958.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS24588.1 [Q60766-1]

NCBI Reference Sequences

More...RefSeqi		NP_032352.1, NM_008326.1 [Q60766-1]

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Mm.29938

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000049519; ENSMUSP00000050446; ENSMUSG00000046879 [Q60766-1]
ENSMUST00000097271; ENSMUSP00000094870; ENSMUSG00000046879 [Q60766-2]
ENSMUST00000229243; ENSMUSP00000155118; ENSMUSG00000116444 [Q60766-1]
ENSMUST00000230442; ENSMUSP00000154822; ENSMUSG00000116444 [Q60766-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		15944

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:15944

UCSC genome browser

More...UCSCi		uc007ipg.1 mouse [Q60766-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19119 mRNA Translation: AAB48942.1
AK002545 mRNA Translation: BAB22176.1
AK167558 mRNA Translation: BAE39622.1
AK171743 mRNA Translation: BAE42645.1
AL645849 Genomic DNA No translation available.
BC145957 mRNA Translation: AAI45958.1
CCDSiCCDS24588.1 [Q60766-1]
RefSeqiNP_032352.1, NM_008326.1 [Q60766-1]
UniGeneiMm.29938

3D structure databases

ProteinModelPortaliQ60766
SMRiQ60766
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200520, 1 interactor
IntActiQ60766, 2 interactors
MINTiQ60766
STRINGi10090.ENSMUSP00000050446

PTM databases

iPTMnetiQ60766
PhosphoSitePlusiQ60766
SwissPalmiQ60766

Proteomic databases

jPOSTiQ60766
PaxDbiQ60766
PeptideAtlasiQ60766
PRIDEiQ60766

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000049519; ENSMUSP00000050446; ENSMUSG00000046879 [Q60766-1]
ENSMUST00000097271; ENSMUSP00000094870; ENSMUSG00000046879 [Q60766-2]
ENSMUST00000229243; ENSMUSP00000155118; ENSMUSG00000116444 [Q60766-1]
ENSMUST00000230442; ENSMUSP00000154822; ENSMUSG00000116444 [Q60766-1]
GeneIDi15944
KEGGimmu:15944
UCSCiuc007ipg.1 mouse [Q60766-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		15944
MGIiMGI:107567 Irgm1

Phylogenomic databases

eggNOGiENOG410J94V Eukaryota
ENOG4111A9F LUCA
GeneTreeiENSGT00940000153722
HOVERGENiHBG101048
InParanoidiQ60766
KOiK14139
OrthoDBi688334at2759
PhylomeDBiQ60766
TreeFamiTF331897

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q60766

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000046879 Expressed in 215 organ(s), highest expression level in submandibular gland
ExpressionAtlasiQ60766 baseline and differential
GenevisibleiQ60766 MM

Family and domain databases

InterProiView protein in InterPro
IPR030385 G_IRG_dom
IPR007743 Immunity-related_GTPase-like
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF05049 IIGP, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51716 G_IRG, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRGM1_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60766
Secondary accession number(s): Q3TJ73
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: November 1, 1996
Last modified: January 16, 2019
This is version 135 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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