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Protein

Cyclic AMP-dependent transcription factor ATF-3

Gene

Atf3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • cellular response to amino acid starvation Source: ParkinsonsUK-UCL
  • endoplasmic reticulum unfolded protein response Source: ParkinsonsUK-UCL
  • gluconeogenesis Source: MGI
  • negative regulation of ERK1 and ERK2 cascade Source: CACAO
  • negative regulation of transcription, DNA-templated Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: NTNU_SB
  • positive regulation of cell proliferation Source: MGI
  • positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway Source: MGI
  • positive regulation of gene expression Source: ParkinsonsUK-UCL
  • positive regulation of TRAIL-activated apoptotic signaling pathway Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress Source: MGI
  • skeletal muscle cell differentiation Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclic AMP-dependent transcription factor ATF-3
Short name:
cAMP-dependent transcription factor ATF-3
Alternative name(s):
Activating transcription factor 3
Transcription factor LRG-21
Gene namesi
Name:Atf3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:109384 Atf3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000765821 – 181Cyclic AMP-dependent transcription factor ATF-3Add BLAST181

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki78Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei162PhosphothreonineBy similarity1
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ60765
PaxDbiQ60765
PRIDEiQ60765

PTM databases

iPTMnetiQ60765
PhosphoSitePlusiQ60765

Expressioni

Inductioni

By stress.1 Publication

Gene expression databases

BgeeiENSMUSG00000026628
CleanExiMM_ATF3
ExpressionAtlasiQ60765 baseline and differential
GenevisibleiQ60765 MM

Interactioni

Subunit structurei

Binds DNA as a homodimer or a heterodimer.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198234, 5 interactors
STRINGi10090.ENSMUSP00000027941

Structurei

3D structure databases

ProteinModelPortaliQ60765
SMRiQ60765
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini86 – 149bZIPPROSITE-ProRule annotationAdd BLAST64

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni88 – 110Basic motifPROSITE-ProRule annotationAdd BLAST23
Regioni114 – 142Leucine-zipperPROSITE-ProRule annotationAdd BLAST29

Sequence similaritiesi

Belongs to the bZIP family. ATF subfamily.Curated

Phylogenomic databases

eggNOGiKOG1414 Eukaryota
ENOG4111CH5 LUCA
GeneTreeiENSGT00730000110847
HOGENOMiHOG000034126
HOVERGENiHBG003381
InParanoidiQ60765
KOiK09032
OMAiLVYMLNL
OrthoDBiEOG091G0M4N
PhylomeDBiQ60765
TreeFamiTF326301

Family and domain databases

InterProiView protein in InterPro
IPR000837 AP-1
IPR029812 ATF3
IPR004827 bZIP
PANTHERiPTHR23351 PTHR23351, 1 hit
PTHR23351:SF23 PTHR23351:SF23, 1 hit
PfamiView protein in Pfam
PF00170 bZIP_1, 1 hit
PRINTSiPR00042 LEUZIPPRFOS
SMARTiView protein in SMART
SM00338 BRLZ, 1 hit
PROSITEiView protein in PROSITE
PS50217 BZIP, 1 hit
PS00036 BZIP_BASIC, 1 hit

Sequencei

Sequence statusi: Complete.

Q60765-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLQHPGQVS ASEVSATAIV PCLSPPGSLV FEDFANLTPF VKEELRFAIQ
60 70 80 90 100
NKHLCHRMSS ALESVTVNNR PLEMSVTKSE AAPEEDERKR RRRERNKIAA
110 120 130 140 150
AKCRNKKKEK TECLQKESEK LESVNAELKA QIEELKNEKQ HLIYMLNLHR
160 170 180
PTCIVRAQNG RTPEDERNLF IQQIKEGTLQ S
Length:181
Mass (Da):20,722
Last modified:November 1, 1996 - v1
Checksum:iD641C8C6D14A457D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U19118 mRNA Translation: AAB48941.1
BC019946 mRNA Translation: AAH19946.1
BC064799 mRNA Translation: AAH64799.1
CCDSiCCDS15616.1
RefSeqiNP_031524.2, NM_007498.3
UniGeneiMm.2706

Genome annotation databases

EnsembliENSMUST00000027941; ENSMUSP00000027941; ENSMUSG00000026628
ENSMUST00000195117; ENSMUSP00000141492; ENSMUSG00000026628
GeneIDi11910
KEGGimmu:11910
UCSCiuc007ece.1 mouse

Similar proteinsi

Entry informationi

Entry nameiATF3_MOUSE
AccessioniPrimary (citable) accession number: Q60765
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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