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Protein

Transcription factor 15

Gene

Tcf15

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May function as an early transcriptional regulator, involved in the patterning of the mesoderm and in lineage determination of cell types derived from the mesoderm.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor 15
Short name:
TCF-15
Alternative name(s):
Meso1
Paraxis
Protein bHLH-EC2
Gene namesi
Name:Tcf15
Synonyms:Bhlhec2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:104664 Tcf15

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001274621 – 195Transcription factor 15Add BLAST195

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei60PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ60756
PRIDEiQ60756

PTM databases

iPTMnetiQ60756
PhosphoSitePlusiQ60756

Expressioni

Tissue specificityi

Expressed in heart and skeletal muscle.

Developmental stagei

At 7.5 dpc, low expression is detected in a subdomain of the primitive mesoderm. At 8.5 dpc, expressed at high levels throughout the uncompartmentalized epithelial somites and in the rostral paraxial mesoderm. By 9.5 dpc, expression is confined to the somite and is most prominent in the myotome and dermatome. At 10 dpc, expression in somite declines in the myotome but persists at high level in the dermatome. At 10.5 dpc, expression is seen only in the somites in the caudal portion of the embryo.

Gene expression databases

BgeeiENSMUSG00000068079 Expressed in 158 organ(s), highest expression level in myocardium of ventricle
CleanExiMM_TCF15
GenevisibleiQ60756 MM

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204001, 2 interactors
STRINGi10090.ENSMUSP00000086511

Structurei

3D structure databases

ProteinModelPortaliQ60756
SMRiQ60756
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini70 – 122bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi50 – 64Gly-richAdd BLAST15

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000231706
HOVERGENiHBG036149
InParanoidiQ60756
KOiK09070
OMAiFAMLRPV
OrthoDBiEOG091G0RR2
PhylomeDBiQ60756
TreeFamiTF315153

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

Q60756-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAFALLRPVG AHVLYPDVRL LSEDEENRSE SDASDQSFGC CEGLEAARRG
60 70 80 90 100
PGPGSGRRAS NGAGPVVVVR QRQAANARER DRTQSVNTAF TALRTLIPTE
110 120 130 140 150
PVDRKLSKIE TLRLASSYIA HLANVLLLGD AADDGQPCFR AAGGGKSAVP
160 170 180 190
AADGRQPRSI CTFCLSNQRK GGSRRDLGGS CLKVRGVAPL RGPRR
Length:195
Mass (Da):20,721
Last modified:November 25, 2002 - v2
Checksum:iF659B94C5F125E56
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti130 – 131DA → ELT in AAA86825 (PubMed:7729571).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18658 mRNA Translation: AAA86825.1
BC027533 mRNA Translation: AAH27533.1
U20164 Genomic DNA Translation: AAB48215.1
CCDSiCCDS16878.1
RefSeqiNP_033354.2, NM_009328.2
UniGeneiMm.3881

Genome annotation databases

EnsembliENSMUST00000089112; ENSMUSP00000086511; ENSMUSG00000068079
GeneIDi21407
KEGGimmu:21407
UCSCiuc008nex.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U18658 mRNA Translation: AAA86825.1
BC027533 mRNA Translation: AAH27533.1
U20164 Genomic DNA Translation: AAB48215.1
CCDSiCCDS16878.1
RefSeqiNP_033354.2, NM_009328.2
UniGeneiMm.3881

3D structure databases

ProteinModelPortaliQ60756
SMRiQ60756
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204001, 2 interactors
STRINGi10090.ENSMUSP00000086511

PTM databases

iPTMnetiQ60756
PhosphoSitePlusiQ60756

Proteomic databases

PaxDbiQ60756
PRIDEiQ60756

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000089112; ENSMUSP00000086511; ENSMUSG00000068079
GeneIDi21407
KEGGimmu:21407
UCSCiuc008nex.1 mouse

Organism-specific databases

CTDi6939
MGIiMGI:104664 Tcf15

Phylogenomic databases

eggNOGiKOG4029 Eukaryota
ENOG411227D LUCA
GeneTreeiENSGT00760000119097
HOGENOMiHOG000231706
HOVERGENiHBG036149
InParanoidiQ60756
KOiK09070
OMAiFAMLRPV
OrthoDBiEOG091G0RR2
PhylomeDBiQ60756
TreeFamiTF315153

Miscellaneous databases

PROiPR:Q60756
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000068079 Expressed in 158 organ(s), highest expression level in myocardium of ventricle
CleanExiMM_TCF15
GenevisibleiQ60756 MM

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR036638 HLH_DNA-bd_sf
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiTCF15_MOUSE
AccessioniPrimary (citable) accession number: Q60756
Secondary accession number(s): Q60788
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: November 25, 2002
Last modified: September 12, 2018
This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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