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Protein

Cytochrome b561

Gene

Cyb561

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Secretory vesicle-specific electron transport protein.

Cofactori

hemeBy similarityNote: Binds 2 heme groups non-covalently.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi86Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi90Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi108Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi120Iron (heme axial ligand)PROSITE-ProRule annotation1
Metal bindingi159Iron (heme axial ligand)PROSITE-ProRule annotation1

GO - Molecular functioni

  • ferric-chelate reductase activity Source: HGNC
  • metal ion binding Source: UniProtKB-KW
  • oxidoreductase activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processElectron transport, Transport
LigandHeme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b561
Alternative name(s):
Cytochrome b-561
Gene namesi
Name:Cyb561
Synonyms:Mcyt
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103253 Cyb561

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15CytoplasmicSequence analysisAdd BLAST15
Transmembranei16 – 36HelicalSequence analysisAdd BLAST21
Transmembranei51 – 71HelicalSequence analysisAdd BLAST21
Transmembranei84 – 104HelicalSequence analysisAdd BLAST21
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Transmembranei158 – 178HelicalSequence analysisAdd BLAST21
Transmembranei198 – 218HelicalSequence analysisAdd BLAST21
Topological domaini219 – 250CytoplasmicSequence analysisAdd BLAST32

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001510281 – 250Cytochrome b561Add BLAST250

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei246PhosphoserineCombined sources1
Modified residuei248PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ60720
PaxDbiQ60720
PRIDEiQ60720

PTM databases

iPTMnetiQ60720
PhosphoSitePlusiQ60720

Expressioni

Tissue specificityi

Abundantly distributed in a number of neuroendocrine tissues.

Gene expression databases

BgeeiENSMUSG00000019590 Expressed in 271 organ(s), highest expression level in choroid plexus of fourth ventricle
CleanExiMM_CYB561
ExpressionAtlasiQ60720 baseline and differential
GenevisibleiQ60720 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019734

Structurei

3D structure databases

ProteinModelPortaliQ60720
SMRiQ60720
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini18 – 219Cytochrome b561PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1619 Eukaryota
ENOG4111FKI LUCA
GeneTreeiENSGT00390000010986
HOGENOMiHOG000231043
HOVERGENiHBG054164
InParanoidiQ60720
KOiK08360
OMAiYRPQHVF
OrthoDBiEOG091G0GC6
PhylomeDBiQ60720
TreeFamiTF314222

Family and domain databases

InterProiView protein in InterPro
IPR006593 Cyt_b561/ferric_Rdtase_TM
IPR028837 Cytochrome_b561
PANTHERiPTHR10106:SF14 PTHR10106:SF14, 1 hit
PfamiView protein in Pfam
PF03188 Cytochrom_B561, 1 hit
SMARTiView protein in SMART
SM00665 B561, 1 hit
PROSITEiView protein in PROSITE
PS50939 CYTOCHROME_B561, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

Q60720-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEHSSASVPA ALPYYVAFSQ LLGLTVVAVT GAWLGLYRGG IAWESSLQFN
60 70 80 90 100
VHPLCMVIGM IFLQGDALLV YRVFRREAKR TTKILHGLLH VFAFIIALVG
110 120 130 140 150
LVAVFDYHKK KGYADLYSLH SWCGILVFVL YFVQWLVGFS FFLFPGASFS
160 170 180 190 200
LRSRYRPQHI FFGATIFLFS VGTALLGLKE ALLFKLGSKY STFEPEGVLA
210 220 230 240 250
NVLGLLLVCF GVVVLYILAQ ADWKRPSQAE EQALSMDFKT LTEGDSPSPQ
Length:250
Mass (Da):27,822
Last modified:November 25, 2002 - v2
Checksum:iD0FDE6C9DE5EA09E
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GX11V9GX11_MOUSE
Cytochrome b561
Cyb561
192Annotation score:
A2A685A2A685_MOUSE
Cytochrome b561
Cyb561
209Annotation score:
V9GWY3V9GWY3_MOUSE
Cytochrome b561
Cyb561
181Annotation score:
V9GWU6V9GWU6_MOUSE
Cytochrome b561
Cyb561
99Annotation score:
V9GXF4V9GXF4_MOUSE
Cytochrome b561
Cyb561
106Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9 – 21PAALP…AFSQL → LLHCRTMWPSPSC in AAA65643 (PubMed:9778036).CuratedAdd BLAST13
Sequence conflicti171 – 174VGTA → AGHS in AAA65643 (PubMed:9778036).Curated4
Sequence conflicti199L → V in AAA65643 (PubMed:9778036).Curated1
Sequence conflicti222 – 226DWKRP → ALERG in AAA65643 (PubMed:9778036).Curated5
Sequence conflicti248 – 249SP → TS in AAA65643 (PubMed:9778036).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16297 mRNA Translation: AAA65643.1
AK014395 mRNA Translation: BAB29321.1
AK158978 mRNA Translation: BAE34753.1
AK169711 mRNA Translation: BAE41322.1
BC006732 mRNA Translation: AAH06732.1
CCDSiCCDS25542.1
RefSeqiNP_031831.2, NM_007805.4
XP_006532193.1, XM_006532130.3
XP_006532194.1, XM_006532131.2
XP_006532195.1, XM_006532132.3
UniGeneiMm.149403

Genome annotation databases

EnsembliENSMUST00000019734; ENSMUSP00000019734; ENSMUSG00000019590
GeneIDi13056
KEGGimmu:13056
UCSCiuc007lxr.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16297 mRNA Translation: AAA65643.1
AK014395 mRNA Translation: BAB29321.1
AK158978 mRNA Translation: BAE34753.1
AK169711 mRNA Translation: BAE41322.1
BC006732 mRNA Translation: AAH06732.1
CCDSiCCDS25542.1
RefSeqiNP_031831.2, NM_007805.4
XP_006532193.1, XM_006532130.3
XP_006532194.1, XM_006532131.2
XP_006532195.1, XM_006532132.3
UniGeneiMm.149403

3D structure databases

ProteinModelPortaliQ60720
SMRiQ60720
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000019734

PTM databases

iPTMnetiQ60720
PhosphoSitePlusiQ60720

Proteomic databases

MaxQBiQ60720
PaxDbiQ60720
PRIDEiQ60720

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019734; ENSMUSP00000019734; ENSMUSG00000019590
GeneIDi13056
KEGGimmu:13056
UCSCiuc007lxr.1 mouse

Organism-specific databases

CTDi1534
MGIiMGI:103253 Cyb561

Phylogenomic databases

eggNOGiKOG1619 Eukaryota
ENOG4111FKI LUCA
GeneTreeiENSGT00390000010986
HOGENOMiHOG000231043
HOVERGENiHBG054164
InParanoidiQ60720
KOiK08360
OMAiYRPQHVF
OrthoDBiEOG091G0GC6
PhylomeDBiQ60720
TreeFamiTF314222

Miscellaneous databases

PROiPR:Q60720
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019590 Expressed in 271 organ(s), highest expression level in choroid plexus of fourth ventricle
CleanExiMM_CYB561
ExpressionAtlasiQ60720 baseline and differential
GenevisibleiQ60720 MM

Family and domain databases

InterProiView protein in InterPro
IPR006593 Cyt_b561/ferric_Rdtase_TM
IPR028837 Cytochrome_b561
PANTHERiPTHR10106:SF14 PTHR10106:SF14, 1 hit
PfamiView protein in Pfam
PF03188 Cytochrom_B561, 1 hit
SMARTiView protein in SMART
SM00665 B561, 1 hit
PROSITEiView protein in PROSITE
PS50939 CYTOCHROME_B561, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCY561_MOUSE
AccessioniPrimary (citable) accession number: Q60720
Secondary accession number(s): Q3TEC6, Q9D6C9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 25, 2002
Last modified: November 7, 2018
This is version 141 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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