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Protein

Forkhead box protein D4

Gene

Foxd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi102 – 193Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein D4
Alternative name(s):
Forkhead-related protein FKHL9
Forkhead-related transcription factor 5
Short name:
FREAC-5
Transcription factor FKH-2
Gene namesi
Name:Foxd4
Synonyms:Fkh2, Fkhl9, Freac5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1347467 Foxd4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918221 – 444Forkhead box protein D4Add BLAST444

Proteomic databases

PaxDbiQ60688
PRIDEiQ60688

PTM databases

iPTMnetiQ60688
PhosphoSitePlusiQ60688

Expressioni

Tissue specificityi

Not detected in any adult tissues tested.

Developmental stagei

Expressed in headfold stage embryos in the notochord, the anterior neuroectoderm, and a few cells of the definite endoderm. This expression becomes restricted to the anteriormost portions of the invaginating foregut and the developing midbrain. From day 11.5 of gestation onward, FOXD4 transcripts are restricted to the midbrain and become progressively localized to the red nuclei as the sole site of expression.

Gene expression databases

BgeeiENSMUSG00000051490 Expressed in 28 organ(s), highest expression level in head
CleanExiMM_FOXD4
GenevisibleiQ60688 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058575

Structurei

3D structure databases

ProteinModelPortaliQ60688
SMRiQ60688
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi21 – 47Asp/Glu-richAdd BLAST27
Compositional biasi204 – 296Ala/Pro-richAdd BLAST93

Domaini

Contains two potential transactivation domains A and B.

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231285
HOVERGENiHBG051641
InParanoidiQ60688
KOiK09397
OMAiCAISCAP
OrthoDBiEOG091G0HW9
PhylomeDBiQ60688
TreeFamiTF316127

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

Q60688-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNSARAGHLR STPPPSPLSS DQDEVEIDVL AEEEDGDQTE EEDDEEESHK
60 70 80 90 100
CLERSLQRPG ARTLAGRSAG DCGDLSNSSG FLRKFRAPRT PATTTADGPQ
110 120 130 140 150
PAKPPYSYIA LITMAILQSP HKRLTLSGIC AFISGRFPYY RRKFPAWQNS
160 170 180 190 200
IRHNLSLNDC FVKIPREPGH PGKGNYWSLD PASQDMFDNG SFLRRRKRFK
210 220 230 240 250
RHHPPSGGHP HCPFPPPAVP ATLHVSQPSL LLRYSAPPQP NLAAHPAAPP
260 270 280 290 300
RSHPCAPLHP HPMRYLLLAA PAYGDNPRKA EGADPATPLA IPALQPVLGS
310 320 330 340 350
QPWERDQSSG TRSGRGCASF TIESIMQGVT GGGTGSAQSP SFAPWSYCHL
360 370 380 390 400
LQHPPCLLHP QAASPLFHMS AGSRTILPQQ PQPPLPLQQE QHHCAISCAP
410 420 430 440
GKGVRLGQHL SAVAALLRQQ PAADDGRLTT LAALSGREGT LPEF
Length:444
Mass (Da):48,047
Last modified:November 1, 1997 - v1
Checksum:iFFDC8EDDC6FC18FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti201 – 204RHHP → PTTR in CAA50742 (PubMed:7689224).Curated4

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86368 Genomic DNA Translation: CAA60128.1
BC138432 mRNA Translation: AAI38433.1
BC138434 mRNA Translation: AAI38435.1
X71940 Genomic DNA Translation: CAA50742.1
CCDSiCCDS29715.1
PIRiB47746
RefSeqiNP_032048.1, NM_008022.2
UniGeneiMm.377080

Genome annotation databases

EnsembliENSMUST00000058600; ENSMUSP00000058575; ENSMUSG00000051490
GeneIDi14237
KEGGimmu:14237
UCSCiuc008hav.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86368 Genomic DNA Translation: CAA60128.1
BC138432 mRNA Translation: AAI38433.1
BC138434 mRNA Translation: AAI38435.1
X71940 Genomic DNA Translation: CAA50742.1
CCDSiCCDS29715.1
PIRiB47746
RefSeqiNP_032048.1, NM_008022.2
UniGeneiMm.377080

3D structure databases

ProteinModelPortaliQ60688
SMRiQ60688
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058575

PTM databases

iPTMnetiQ60688
PhosphoSitePlusiQ60688

Proteomic databases

PaxDbiQ60688
PRIDEiQ60688

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000058600; ENSMUSP00000058575; ENSMUSG00000051490
GeneIDi14237
KEGGimmu:14237
UCSCiuc008hav.1 mouse

Organism-specific databases

CTDi2298
MGIiMGI:1347467 Foxd4

Phylogenomic databases

eggNOGiKOG2294 Eukaryota
COG5025 LUCA
GeneTreeiENSGT00760000118904
HOGENOMiHOG000231285
HOVERGENiHBG051641
InParanoidiQ60688
KOiK09397
OMAiCAISCAP
OrthoDBiEOG091G0HW9
PhylomeDBiQ60688
TreeFamiTF316127

Miscellaneous databases

PROiPR:Q60688
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000051490 Expressed in 28 organ(s), highest expression level in head
CleanExiMM_FOXD4
GenevisibleiQ60688 MM

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR001766 Fork_head_dom
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFOXD4_MOUSE
AccessioniPrimary (citable) accession number: Q60688
Secondary accession number(s): B2RRJ0, Q61573
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 7, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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