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Protein

Follitropin subunit beta

Gene

Fshb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways (By similarity). Follitropin is involved in follicle development and spermatogenesis in reproductive organs (PubMed:9020850, PubMed:11416011).By similarity2 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-MMU-209822 Glycoprotein hormones
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Follitropin subunit beta
Alternative name(s):
Follicle-stimulating hormone beta subunit
Short name:
FSH-B
Short name:
FSH-beta
Follitropin beta chain
Gene namesi
Name:Fshb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95582 Fshb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Disruption phenotypei

Mice lacking Fshb are viable (PubMed:9020850). Females are infertile displaying abnormal uterus and ovaries that lacked corpora lutea. The infertility is due to impaired follicle maturation which appears before antral follicle formation (PubMed:9020850). Males are fertile and spermatogenesis proceeds normaly. However, these mice display a reduced testes size and epididymal sperm count (PubMed:9020850, PubMed:11416011). The number of Sertoli cells is significantly reduced and their ability to support germ cell development is also affected (PubMed:11416011).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20By similarityAdd BLAST20
ChainiPRO_000001171321 – 130Follitropin subunit betaAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi22 ↔ 70By similarity
Glycosylationi26N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi36 ↔ 85By similarity
Disulfide bondi39 ↔ 123By similarity
Glycosylationi43N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi47 ↔ 101By similarity
Disulfide bondi51 ↔ 103By similarity
Disulfide bondi106 ↔ 113By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60687
PRIDEiQ60687

PTM databases

PhosphoSitePlusiQ60687

Expressioni

Gene expression databases

BgeeiENSMUSG00000027120 Expressed in 15 organ(s), highest expression level in pituitary gland
CleanExiMM_FSHB
ExpressionAtlasiQ60687 baseline and differential
GenevisibleiQ60687 MM

Interactioni

Subunit structurei

Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028533

Structurei

3D structure databases

ProteinModelPortaliQ60687
SMRiQ60687
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWHY Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiQ60687
KOiK05250
OMAiAVEKEEC
OrthoDBiEOG091G0XFH
PhylomeDBiQ60687
TreeFamiTF332940

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60687-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMKLIQLCIL FWCWRAICCH SCELTNITIS VEKEECRFCI SINTTWCAGY
60 70 80 90 100
CYTRDLVYKD PARPNTQKVC TFKELVYETV RLPGCARHSD SLYTYPVATE
110 120 130
CHCGKCDSDS TDCTVRGLGP SYCSFSEMKE
Length:130
Mass (Da):14,919
Last modified:November 1, 1996 - v1
Checksum:i7F9C28C2E34AC161
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12932 Genomic DNA Translation: AAA92804.1
AK017593 mRNA Translation: BAB30827.1
BC061159 mRNA Translation: AAH61159.1
CCDSiCCDS16504.1
PIRiJC4526
RefSeqiNP_032071.1, NM_008045.3
UniGeneiMm.249525

Genome annotation databases

EnsembliENSMUST00000028533; ENSMUSP00000028533; ENSMUSG00000027120
GeneIDi14308
KEGGimmu:14308
UCSCiuc008llt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12932 Genomic DNA Translation: AAA92804.1
AK017593 mRNA Translation: BAB30827.1
BC061159 mRNA Translation: AAH61159.1
CCDSiCCDS16504.1
PIRiJC4526
RefSeqiNP_032071.1, NM_008045.3
UniGeneiMm.249525

3D structure databases

ProteinModelPortaliQ60687
SMRiQ60687
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028533

PTM databases

PhosphoSitePlusiQ60687

Proteomic databases

PaxDbiQ60687
PRIDEiQ60687

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028533; ENSMUSP00000028533; ENSMUSG00000027120
GeneIDi14308
KEGGimmu:14308
UCSCiuc008llt.1 mouse

Organism-specific databases

CTDi2488
MGIiMGI:95582 Fshb

Phylogenomic databases

eggNOGiENOG410IWHY Eukaryota
ENOG4111ZSU LUCA
GeneTreeiENSGT00390000010115
HOGENOMiHOG000116098
HOVERGENiHBG006698
InParanoidiQ60687
KOiK05250
OMAiAVEKEEC
OrthoDBiEOG091G0XFH
PhylomeDBiQ60687
TreeFamiTF332940

Enzyme and pathway databases

ReactomeiR-MMU-209822 Glycoprotein hormones
R-MMU-375281 Hormone ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

PROiPR:Q60687
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027120 Expressed in 15 organ(s), highest expression level in pituitary gland
CleanExiMM_FSHB
ExpressionAtlasiQ60687 baseline and differential
GenevisibleiQ60687 MM

Family and domain databases

CDDicd00069 GHB_like, 1 hit
Gene3Di2.10.90.10, 1 hit
InterProiView protein in InterPro
IPR029034 Cystine-knot_cytokine
IPR006208 Glyco_hormone_CN
IPR001545 Gonadotropin_bsu
IPR018245 Gonadotropin_bsu_CS
PANTHERiPTHR11515 PTHR11515, 1 hit
PfamiView protein in Pfam
PF00007 Cys_knot, 1 hit
SMARTiView protein in SMART
SM00068 GHB, 1 hit
SUPFAMiSSF57501 SSF57501, 1 hit
PROSITEiView protein in PROSITE
PS00261 GLYCO_HORMONE_BETA_1, 1 hit
PS00689 GLYCO_HORMONE_BETA_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFSHB_MOUSE
AccessioniPrimary (citable) accession number: Q60687
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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