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Protein

Integrin alpha-E

Gene

Itgae

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Integrin alpha-E/beta-7 is a receptor for E-cadherin. It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers. Mice expressing a null mutation of the alpha-E subunit gene exhibit a marked reduction in the numbers of intraepithelial lymphocytes in the gut and in the development of gut-associated lymphoid aggregates, supporting a specific role for this integrin in mediating retention of lymphocytes in the intestinal wall.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi514 – 522Sequence analysis9
Calcium bindingi578 – 586Sequence analysis9
Calcium bindingi646 – 654Sequence analysis9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIntegrin, Receptor
Biological processCell adhesion
LigandCalcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-216083 Integrin cell surface interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Integrin alpha-E
Alternative name(s):
Integrin alpha M290
CD_antigen: CD103
Cleaved into the following 2 chains:
Gene namesi
Name:Itgae
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1298377 Itgae

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1114ExtracellularSequence analysisAdd BLAST1095
Transmembranei1115 – 1137HelicalSequence analysisAdd BLAST23
Topological domaini1138 – 1167CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19By similarityAdd BLAST19
ChainiPRO_000001628620 – 1167Integrin alpha-EAdd BLAST1148
ChainiPRO_000001628720 – 181Integrin alpha-E light chainAdd BLAST162
ChainiPRO_0000016288183 – 1167Integrin alpha-E heavy chainAdd BLAST985

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi72 ↔ 83By similarity
Disulfide bondi130 ↔ 164By similarity
Glycosylationi256N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi314N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi341N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi364N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi418N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi437N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi698 ↔ 754By similarity
Glycosylationi718N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi773N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi814 ↔ 820By similarity
Glycosylationi829N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi846N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi884 ↔ 898By similarity
Glycosylationi911N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi925N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi968N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi998 ↔ 1023By similarity
Glycosylationi1013N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1031 ↔ 1047By similarity
Glycosylationi1055N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1086N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ60677
MaxQBiQ60677
PaxDbiQ60677
PRIDEiQ60677

PTM databases

iPTMnetiQ60677
PhosphoSitePlusiQ60677

Expressioni

Gene expression databases

BgeeiENSMUSG00000005947
CleanExiMM_ITGAE
ExpressionAtlasiQ60677 baseline and differential
GenevisibleiQ60677 MM

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chains linked by a disulfide bond. Alpha-E associates with beta-7.

Protein-protein interaction databases

ComplexPortaliCPX-3127 Integrin alphaE-beta7 complex
STRINGi10090.ENSMUSP00000006101

Structurei

3D structure databases

ProteinModelPortaliQ60677
SMRiQ60677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati27 – 81FG-GAP 1Add BLAST55
Repeati84 – 142FG-GAP 2PROSITE-ProRule annotationAdd BLAST59
Domaini193 – 382VWFAPROSITE-ProRule annotationAdd BLAST190
Repeati383 – 435FG-GAP 3PROSITE-ProRule annotationAdd BLAST53
Repeati438 – 491FG-GAP 4PROSITE-ProRule annotationAdd BLAST54
Repeati492 – 552FG-GAP 5PROSITE-ProRule annotationAdd BLAST61
Repeati555 – 619FG-GAP 6PROSITE-ProRule annotationAdd BLAST65
Repeati623 – 683FG-GAP 7PROSITE-ProRule annotationAdd BLAST61

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni149 – 192X-domain (extra domain)Add BLAST44

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi1140 – 1144GFFKR motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi185 – 191Glu-rich (acidic)7

Domaini

The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

Sequence similaritiesi

Belongs to the integrin alpha chain family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPAZ Eukaryota
ENOG410XR7I LUCA
GeneTreeiENSGT00760000118782
HOGENOMiHOG000049185
HOVERGENiHBG006187
InParanoidiQ60677
KOiK06524
OMAiKMQGVER
OrthoDBiEOG091G09V5
TreeFamiTF105391

Family and domain databases

Gene3Di2.130.10.130, 2 hits
3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR013517 FG-GAP
IPR013519 Int_alpha_beta-p
IPR000413 Integrin_alpha
IPR013649 Integrin_alpha-2
IPR018184 Integrin_alpha_C_CS
IPR028994 Integrin_alpha_N
IPR032695 Integrin_dom_sf
IPR002035 VWF_A
IPR036465 vWFA_dom_sf
PfamiView protein in Pfam
PF01839 FG-GAP, 2 hits
PF00357 Integrin_alpha, 1 hit
PF08441 Integrin_alpha2, 1 hit
PF00092 VWA, 1 hit
PRINTSiPR01185 INTEGRINA
SMARTiView protein in SMART
SM00191 Int_alpha, 4 hits
SM00327 VWA, 1 hit
SUPFAMiSSF53300 SSF53300, 1 hit
SSF69179 SSF69179, 2 hits
PROSITEiView protein in PROSITE
PS51470 FG_GAP, 6 hits
PS00242 INTEGRIN_ALPHA, 1 hit
PS50234 VWFA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q60677-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWLFHTLLC MASLKPQGAF NLDVDWAWVT ALQPGAPAVL SSLLHQDPSN
60 70 80 90 100
NQTCLLVARR SSNRNTAALY RCAISISPDE IACQPVEHIC MPKGRYQGVT
110 120 130 140 150
LVGNHNGVLV CIQVQARKFR SLNSELTGAC SLLTPNLDLQ AQAYFSDLEG
160 170 180 190 200
FLDPGAHVDS GDYCRSKGGS TGEEKKSARR RRTVEEEDEE EDGTEIAIVL
210 220 230 240 250
DGSGSIEPSD FQKAKNFIST MMRNFYEKCF ECNFALVQYG AVIQTEFDLQ
260 270 280 290 300
ESRDINASLA KVQSIVQVKE VTKTASAMQH VLDNIFIPSR GSRKKALKVM
310 320 330 340 350
VVLTDGDIFG DPLNLTTVIN SPKMQGVVRF AIGVGDAFKN NNTYRELKLI
360 370 380 390 400
ASDPKEAHTF KVTNYSALDG LLSKLQQHIV HMEGTVGDAL QYQLAQTGFS
410 420 430 440 450
AQILDKGQVL LGTVGAFNWS GGALLYSTQN GRGCFLNQTA KEDSRTVQYS
460 470 480 490 500
YLGYSLAVLH KAHGVSYVAG APRHKLRGAV FELRKEDREE DAFVRRIEGE
510 520 530 540 550
QMGSYFGSVL CPVDIDMDGT TDFLLVAAPF YHIRGEEGRV YVYQVPEQDA
560 570 580 590 600
SFSLAHTLSG HPGLTNSRFG FAMAAVGDIN QDKFTDVAIG APLEGFGAGD
610 620 630 640 650
GASYGSVYIY NGHSGGLYDS PSQQIRASSV ASGLHYFGMS VSGGLDFNGD
660 670 680 690 700
GLADITVGSR DSAVVLRSRP VVDLTVSMTF TPDALPMVFI GKMDVKLCFE
710 720 730 740 750
VDSSGVASEP GLREMFLNFT VDVDVTKQRQ RLQCEDSSGC QSCLRKWNGG
760 770 780 790 800
SFLCEHFWLI STEELCEEDC FSNITIKVTY EFQTSGGRRD YPNPTLDHYK
810 820 830 840 850
EPSAIFQLPY EKDCKNKVFC IAEIQLTTNI SQQELVVGVT KEVTMNISLT
860 870 880 890 900
NSGEDSYMTN MALNYPRNLQ FKKIQKPVSP DVQCDDPKPV ASVLVMNCKI
910 920 930 940 950
GHPILKRSSV NVSVTWQLEE SVFPNRTADI TVTISNSNEK SLARETRSLQ
960 970 980 990 1000
FRHAFIAVLS RPSVMYMNTS QSPSDHKEFF FNVHGENLFG AVFQLQICVP
1010 1020 1030 1040 1050
IKLQDFQIVR VKNLTKTQDH TECTQSQEPA CGSDPVQHVK EWHSVVCAIT
1060 1070 1080 1090 1100
SNKENVTVAA EISVGHTKQL LRDVSELPIL GEISFNKSLY EGLNAENHRT
1110 1120 1130 1140 1150
KITVIFLKEE ETRSLPLIIG SSIGGLLVLV VIIAILFKCG FFKRKYQQLN
1160
LESTRRAQLK ADSLLQD
Length:1,167
Mass (Da):128,906
Last modified:July 27, 2011 - v2
Checksum:i7534783B341175E5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22L → M in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti46Q → L in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti207E → G in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti337A → R in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti378H → R in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti465V → I in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti696K → N in AAC52142 (PubMed:7882170).Curated1
Sequence conflicti705G → V in AAC52142 (PubMed:7882170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U12236 mRNA Translation: AAC52142.1
AL670399 Genomic DNA No translation available.
CCDSiCCDS24995.1
RefSeqiNP_032425.2, NM_008399.2
UniGeneiMm.96

Genome annotation databases

EnsembliENSMUST00000006101; ENSMUSP00000006101; ENSMUSG00000005947
GeneIDi16407
KEGGimmu:16407
UCSCiuc007jzy.2 mouse

Similar proteinsi

Entry informationi

Entry nameiITAE_MOUSE
AccessioniPrimary (citable) accession number: Q60677
Secondary accession number(s): B1AUD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: June 20, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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