PR domain zinc finger protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• histone deacetylase binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • 18845144
• metal ion binding Source: UniProtKB-KW
• methyltransferase activity Source: UniProtKB-KW
• promoter-specific chromatin binding Source: UniProtKBInferred from direct assayⁱ
  • 27102484
• RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI
• sequence-specific DNA binding Source: MGIInferred from direct assayⁱ
  • 18845144
• transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding Source: MGI

GO - Biological processⁱ

• adaptive immune response Source: UniProtKB-KW
• aorta development Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • 25807483
• artery morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • 24821700
• cardiac septum development Source: MGIInferred from mutant phenotypeⁱ
  • 25807483
• cell fate commitment Source: MGIInferred from mutant phenotypeⁱ
  • 15750184
  • 15937476
• coronary vasculature development Source: MGIInferred from mutant phenotypeⁱ
  • 25807483
• embryonic placenta development Source: MGIInferred from mutant phenotypeⁱ
  • 15750184
• eye photoreceptor cell development Source: MGIInferred from mutant phenotypeⁱ
  • 20463215
• germ cell development Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • 19578360
• heart valve development Source: MGIInferred from mutant phenotypeⁱ
  • 25807483
• innate immune response Source: UniProtKB-KW
• intestinal epithelial cell development Source: MGIInferred from mutant phenotypeⁱ
  • 21670299
• in utero embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • 15750184
• maternal placenta development Source: MGIInferred from mutant phenotypeⁱ
  • 15750184
• morphogenesis of a branching structure Source: MGIInferred from mutant phenotypeⁱ
  • 24821700
• negative regulation of B cell proliferation Source: MGIInferred from direct assayⁱ
  • 18845144
• negative regulation of gene expression Source: MGIInferred from mutant phenotypeⁱ
  • 21670299
• negative regulation of lipopolysaccharide-mediated signaling pathway Source: MGIInferred from direct assayⁱ
  • 18845144
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from direct assayⁱ
  • 18845144
  • 20463215
• positive regulation of B cell differentiation Source: MGIInferred from direct assayⁱ
  • 18845144
• positive regulation of gene expression Source: MGIInferred from direct assayⁱ
  • 18622394
• post-embryonic development Source: MGIInferred from mutant phenotypeⁱ
  • 21670299
• regulation of cell proliferation Source: MGIInferred from mutant phenotypeⁱ
  • 24821700
• regulation of extrathymic T cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27102484
• regulation of natural killer cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27102484
• regulation of NK T cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • 27102484
• sebum secreting cell proliferation Source: MGIInferred from direct assayⁱ
  • 16901790
• transcription, DNA-templated Source: UniProtKB-KW
• trophoblast giant cell differentiation Source: MGIInferred from mutant phenotypeⁱ
  • 22987638
• ventricular septum development Source: MGIInferred from mutant phenotypeⁱ
  • 25807483

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• histone deacetylase binding Source: MGIInferred from direct assayⁱ
  • 18845144

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MREAYLRCWI FSWKNVWVRP CQRLHFKTVL LQGSLLYTAL DSYSTVQAAP 
        60         70         80         90        100
KSSSGSVKFQ GLAETGIMKM DMEDADMTLW TEAEFEEKCT YIVNDHPWDS 
       110        120        130        140        150
GADGGTSVQA EASLPRNLLF KYAANNSKEV IGVVSKEYIP KGTRFGPLIG 
       160        170        180        190        200
EVYTNDTVPK NANRKYFWRI YSREEFHHFI DGFNEEKSNW MRYVNPAHSA 
       210        220        230        240        250
REQNLAACQN GMNIYFYTIK PIPANQELLV WYCRDFAERL HYPYPGELTV 
       260        270        280        290        300
INLTQTESNP KQYSSEKNEL YPKSVPKREY SVKEILKLDS NPSKRKDIYR 
       310        320        330        340        350
SNISPFTLEK DMDGFRKNGS PDMPFYPRVV YPIRAPLPED FLKASLAYGM 
       360        370        380        390        400
ERPTYITHSP LPSSTTPSPP ASSSPEQSLK SSSPHSSPGN TVSPLAPGLP 
       410        420        430        440        450
EHRDSYSYLN VSYGSEGLGS YPGYAPAPHL PPAFIPSYNA HYPKFLLPPY 
       460        470        480        490        500
GISSNGLSTM NNINGINNFS LFPRLYPVYS NLLSGSSLPH PMLNPASLPS 
       510        520        530        540        550
SLPTDGARRL LPPEHPKEVL IPAPHSAFSL TGAAASMKDE SSPPSGSPTA 
       560        570        580        590        600
GTAATSEHVV QPKATSSVMA APSTDGAMNL IKNKRNMTGY KTLPYPLKKQ 
       610        620        630        640        650
NGKIKYECNV CAKTFGQLSN LKVHLRVHSG ERPFKCQTCN KGFTQLAHLQ 
       660        670        680        690        700
KHYLVHTGEK PHECQVCHKR FSSTSNLKTH LRLHSGEKPY QCKVCPAKFT 
       710        720        730        740        750
QFVHLKLHKR LHTRERPHKC AQCHKSYIHL CSLKVHLKGN CPAGPAAGLP 
       760        770        780        790        800
LEDLTRINEE IERFDISDNA DRLEDMEDSV DVTSMVEKEI LAVVRKEKEE 
       810        820        830        840        850
TSLKVSLQRN MGNGLLSSGC SLYESSDLSL MKLPHSNPLP LVPVKVKQET 

VEPMDP                                                 

        10         20         30         40         50
MLDLLLEKRV GTTLAAPKSS SGSVKFQGLA ETGIMKMDME DADMTLWTEA 
        60         70         80         90        100
EFEEKCTYIV NDHPWDSGAD GGTSVQAEAS LPRNLLFKYA ANNSKEVIGV 
       110        120        130        140        150
VSKEYIPKGT RFGPLIGEVY TNDTVPKNAN RKYFWRIYSR EEFHHFIDGF 
       160        170        180        190        200
NEEKSNWMRY VNPAHSAREQ NLAACQNGMN IYFYTIKPIP ANQELLVWYC 
       210        220        230        240        250
RDFAERLHYP YPGELTVINL TQTESNPKQY SSEKNELYPK SVPKREYSVK 
       260        270        280        290        300
EILKLDSNPS KRKDIYRSNI SPFTLEKDMD GFRKNGSPDM PFYPRVVYPI 
       310        320        330        340        350
RAPLPEDFLK ASLAYGMERP TYITHSPLPS STTPSPPASS SPEQSLKSSS 
       360        370        380        390        400
PHSSPGNTVS PLAPGLPEHR DSYSYLNVSY GSEGLGSYPG YAPAPHLPPA 
       410        420        430        440        450
FIPSYNAHYP KFLLPPYGIS SNGLSTMNNI NGINNFSLFP RLYPVYSNLL 
       460        470        480        490        500
SGSSLPHPML NPASLPSSLP TDGARRLLPP EHPKEVLIPA PHSAFSLTGA 
       510        520        530        540        550
AASMKDESSP PSGSPTAGTA ATSEHVVQPK ATSSVMAAPS TDGAMNLIKN 
       560        570        580        590        600
KRNMTGYKTL PYPLKKQNGK IKYECNVCAK TFGQLSNLKV HLRVHSGERP 
       610        620        630        640        650
FKCQTCNKGF TQLAHLQKHY LVHTGEKPHE CQVCHKRFSS TSNLKTHLRL 
       660        670        680        690        700
HSGEKPYQCK VCPAKFTQFV HLKLHKRLHT RERPHKCAQC HKSYIHLCSL 
       710        720        730        740        750
KVHLKGNCPA GPAAGLPLED LTRINEEIER FDISDNADRL EDMEDSVDVT 
       760        770        780        790        800
SMVEKEILAV VRKEKEETSL KVSLQRNMGN GLLSSGCSLY ESSDLSLMKL 
       810        820 
PHSNPLPLVP VKVKQETVEP MDP                              

        10         20         30         40         50
MKMDMEDADM TLWTEAEFEE KCTYIVNDHP WDSGADGGTS VQAEASLPRN 
        60         70         80         90        100
LLFKYAANNS KEVIGVVSKE YIPKGTRFGP LIGEVYTNDT VPKNANRKYF 
       110        120        130        140        150
WRIYSREEFH HFIDGFNEEK SNWMRYVNPA HSAREQNLAA CQNGMNIYFY 
       160        170        180        190        200
TIKPIPANQE LLVWYCRDFA ERLHYPYPGE LTVINLTQTE SNPKQYSSEK 
       210        220        230        240        250
NELYPKSVPK REYSVKEILK LDSNPSKRKD IYRSNISPFT LEKDMDGFRK 
       260        270        280        290        300
NGSPDMPFYP RVVYPIRAPL PEDFLKASLA YGMERPTYIT HSPLPSSTTP 
       310        320        330        340        350
SPPASSSPEQ SLKSSSPHSS PGNTVSPLAP GLPEHRDSYS YLNVSYGSEG 
       360        370        380        390        400
LGSYPGYAPA PHLPPAFIPS YNAHYPKFLL PPYGISSNGL STMNNINGIN 
       410        420        430        440        450
NFSLFPRLYP VYSNLLSGSS LPHPMLNPAS LPSSLPTDGA RRLLPPEHPK 
       460        470        480        490        500
EVLIPAPHSA FSLTGAAASM KDESSPPSGS PTAGTAATSE HVVQPKATSS 
       510        520        530        540        550
VMAAPSTDGA MNLIKNKRNM TGYKTLPYPL KKQNGKIKYE CNVCAKTFGQ 
       560        570        580        590        600
LSNLKVHLRV HSGERPFKCQ TCNKGFTQLA HLQKHYLVHT GEKPHECQVC 
       610        620        630        640        650
HKRFSSTSNL KTHLRLHSGE KPYQCKVCPA KFTQFVHLKL HKRLHTRERP 
       660        670        680        690        700
HKCAQCHKSY IHLCSLKVHL KGNCPAGPAA GLPLEDLTRI NEEIERFDIS 
       710        720        730        740        750
DNADRLEDME DSVDVTSMVE KEILAVVRKE KEETSLKVSL QRNMGNGLLS 
       760        770        780 
SGCSLYESSD LSLMKLPHSN PLPLVPVKVK QETVEPMDP             

        10         20         30         40         50
MTPGVPGHRT QQRPQHISAL SDKAKDCSKA APKSSSGSVK FQGLAETGIM 
        60         70         80         90        100
KMDMEDADMT LWTEAEFEEK CTYIVNDHPW DSGADGGTSV QAEASLPRNL 
       110        120        130        140        150
LFKYAANNSK EVIGVVSKEY IPKGTRFGPL IGEVYTNDTV PKNANRKYFW 
       160        170        180        190        200
RIYSREEFHH FIDGFNEEKS NWMRYVNPAH SAREQNLAAC QNGMNIYFYT 
       210        220        230        240        250
IKPIPANQEL LVWYCRDFAE RLHYPYPGEL TVINLTQTES NPKQYSSEKN 
       260        270        280        290        300
ELYPKSVPKR EYSVKEILKL DSNPSKRKDI YRSNISPFTL EKDMDGFRKN 
       310        320        330        340        350
GSPDMPFYPR VVYPIRAPLP EDFLKASLAY GMERPTYITH SPLPSSTTPS 
       360        370        380        390        400
PPASSSPEQS LKSSSPHSSP GNTVSPLAPG LPEHRDSYSY LNVSYGSEGL 
       410        420        430        440        450
GSYPGYAPAP HLPPAFIPSY NAHYPKFLLP PYGISSNGLS TMNNINGINN 
       460        470        480        490        500
FSLFPRLYPV YSNLLSGSSL PHPMLNPASL PSSLPTDGAR RLLPPEHPKE 
       510        520        530        540        550
VLIPAPHSAF SLTGAAASMK DESSPPSGSP TAGTAATSEH VVQPKATSSV 
       560        570        580        590        600
MAAPSTDGAM NLIKNKRNMT GYKTLPYPLK KQNGKIKYEC NVCAKTFGQL 
       610        620        630        640        650
SNLKVHLRVH SGERPFKCQT CNKGFTQLAH LQKHYLVHTG EKPHECQVCH 
       660        670        680        690        700
KRFSSTSNLK THLRLHSGEK PYQCKVCPAK FTQFVHLKLH KRLHTRERPH 
       710        720        730        740        750
KCAQCHKSYI HLCSLKVHLK GNCPAGPAAG LPLEDLTRIN EEIERFDISD 
       760        770        780        790        800
NADRLEDMED SVDVTSMVEK EILAVVRKEK EETSLKVSLQ RNMGNGLLSS 
       810        820        830 
GCSLYESSDL SLMKLPHSNP LPLVPVKVKQ ETVEPMDP              

        10         20         30         40         50
MREAYLRCWI FSWKNVWVRP CQRLHFKTVL LQGSLLYTAL DSYSTVQAAP 
        60         70         80         90        100
KSSSGSVKFQ GLAETGIMKM DMEDADMTLW TEAEFEEKCT YIVNDHPWDS 
       110        120        130        140        150
GADGGTSVQA EASLPRNLLF KYAANNSKEV IGVVSKEYIP KGTRFGPLIG 
       160        170        180        190        200
EVYTNDTVPK NANRKYFWRI YSREEFHHFI DGFNEEKSNW MRYVNPAHSA 
       210        220        230        240        250
REQNLAACQN GMNIYFYTIK PIPANQELLV WYCRDFAERL HYPYPGELTV 
       260        270        280        290        300
INLTQTESNP KQYSSEKNEL YPKSVPKREY SVKEILKLDS NPSKRKDIYR 
       310        320        330        340        350
SNISPFTLEK DMDGFRKNGS PDMPFYPRVV YPIRAPLPED FLKASLAYGM 
       360        370        380        390        400
ERPTYITHSP LPSSTTPSPP ASSSPEQSLK SSSPHSSPGN TVSPLAPGLP 
       410        420        430        440        450
EHRDSYSYLN VSYGSEGLGS YPGYAPAPHL PPAFIPSYNA HYPKFLLPPY 
       460        470        480        490        500
GISSNGLSTM NNINGINNFS LFPRLYPVYS NLLSGSSLPH PMLNPASLPS 
       510        520        530        540        550
SLPTDGARRL LPPEHPKEVL IPAPHSAFSL TGAAASMKDE SSPPSGSPTA 
       560        570        580        590        600
GTAATSEHVV QPKATSSVMA APSTDGAMNL IKNKRNMTGY KTLPYPLKKQ 
       610        620        630        640        650
NGKIKYECNV CAKTFGQLSN LKVCHKRFSS TSNLKTHLRL HSGEKPYQCK 
       660        670        680        690        700
VCPAKFTQFV HLKLHKRLHT RERPHKCAQC HKSYIHLCSL KVHLKGNCPA 
       710        720        730        740        750
GPAAGLPLED LTRINEEIER FDISDNADRL EDMEDSVDVT SMVEKEILAV 
       760        770        780        790        800
VRKEKEETSL KVSLQRNMGN GLLSSGCSLY ESSDLSLMKL PHSNPLPLVP 
       810 
VKVKQETVEP MDP                                         

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot