UniProtKB - Q60636 (PRDM1_MOUSE)
PR domain zinc finger protein 1
Prdm1
Functioni
Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs (PubMed:27102484).
Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection (PubMed:27102484).
Binds specifically to the PRDI element in the promoter of the beta-interferon gene (By similarity).
Drives the maturation of B-lymphocytes into Ig secreting cells (By similarity).
Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions (PubMed:27102484).
By similarity1 PublicationRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 606 – 628 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 634 – 656 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 662 – 684 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 690 – 712 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription factor activity Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- histone deacetylase binding Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- methyltransferase activity Source: UniProtKB-KW
- promoter-specific chromatin binding Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- aorta development Source: MGI
- artery morphogenesis Source: MGI
- cardiac septum development Source: MGI
- cell fate commitment Source: MGI
- coronary vasculature development Source: MGI
- embryonic placenta development Source: MGI
- eye photoreceptor cell development Source: MGI
- germ cell development Source: MGI
- heart valve development Source: MGI
- innate immune response Source: UniProtKB-KW
- intestinal epithelial cell development Source: MGI
- in utero embryonic development Source: MGI
- kidney development Source: MGI
- maternal placenta development Source: MGI
- methylation Source: UniProtKB-KW
- morphogenesis of a branching structure Source: MGI
- negative regulation of gene expression Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of gene expression Source: MGI
- post-embryonic development Source: MGI
- regulation of cell population proliferation Source: MGI
- regulation of extrathymic T cell differentiation Source: UniProtKB
- regulation of gene expression Source: GO_Central
- regulation of natural killer cell differentiation Source: UniProtKB
- regulation of NK T cell differentiation Source: UniProtKB
- regulation of transcription by RNA polymerase II Source: GO_Central
- sebum secreting cell proliferation Source: MGI
- trophoblast giant cell differentiation Source: MGI
- ventricular septum development Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding, Methyltransferase, Repressor, Transferase |
Biological process | Adaptive immunity, Immunity, Innate immunity, Transcription, Transcription regulation |
Ligand | Metal-binding, S-adenosyl-L-methionine, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: PR domain zinc finger protein 1 (EC:2.1.1.-)Alternative name(s): B lymphocyte-induced maturation protein 1 Short name: Blimp-1 Beta-interferon gene positive regulatory domain I-binding factor PR domain-containing protein 1 |
Gene namesi | Name:Prdm1 Synonyms:Blimp1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99655, Prdm1 |
VEuPathDBi | HostDB:ENSMUSG00000038151 |
Pathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000047758 | 1 – 856 | PR domain zinc finger protein 1Add BLAST | 856 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Cross-linki | 847 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 847 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Ubl conjugationProteomic databases
MaxQBi | Q60636 |
PaxDbi | Q60636 |
PeptideAtlasi | Q60636 |
PRIDEi | Q60636 |
ProteomicsDBi | 291552 [Q60636-1] 291553 [Q60636-2] 291554 [Q60636-3] 291555 [Q60636-4] 291556 [Q60636-5] |
PTM databases
iPTMneti | Q60636 |
PhosphoSitePlusi | Q60636 |
Expressioni
Tissue specificityi
Inductioni
Gene expression databases
Bgeei | ENSMUSG00000038151, Expressed in testis and 229 other tissues |
Genevisiblei | Q60636, MM |
Interactioni
Subunit structurei
Interacts with PRMT5 (PubMed:16699504).
Interacts with FBXO10 (By similarity).
Interacts with FBXO11 (By similarity).
Interacts with multiple nuclear sumoylation E3 ligases, including CBX4, PIAS1, PIAS2, PIAS3, PIAS4, PML and RNF4, but not RANBP2 (By similarity).
Interacts with LDB1, SMARCD3 and SMARCC1 (By similarity).
By similarity1 PublicationBinary interactionsi
Q60636
With | #Exp. | IntAct |
---|---|---|
SUMO1 [P63165] from Homo sapiens. | 3 | EBI-7000804,EBI-80140 |
GO - Molecular functioni
- histone deacetylase binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 198355, 9 interactors |
IntActi | Q60636, 1 interactor |
MINTi | Q60636 |
STRINGi | 10090.ENSMUSP00000101129 |
Miscellaneous databases
RNActi | Q60636, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 115 – 233 | SETPROSITE-ProRule annotationAdd BLAST | 119 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 357 – 399 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 532 – 571 | DisorderedSequence analysisAdd BLAST | 40 | |
Regioni | 558 – 605 | Interaction with PIAS1By similarityAdd BLAST | 48 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 370 – 393 | Polar residuesSequence analysisAdd BLAST | 24 | |
Compositional biasi | 535 – 571 | Polar residuesSequence analysisAdd BLAST | 37 |
Sequence similaritiesi
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 606 – 628 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 634 – 656 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 662 – 684 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 690 – 712 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG2461, Eukaryota |
GeneTreei | ENSGT00940000154798 |
HOGENOMi | CLU_007033_2_1_1 |
InParanoidi | Q60636 |
OMAi | WDCGADG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q60636 |
TreeFami | TF316545 |
Family and domain databases
CDDi | cd19187, PR-SET_PRDM1, 1 hit |
InterProi | View protein in InterPro IPR016608, PRDM1 IPR044413, PRDM1_PR-SET IPR001214, SET_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00856, SET, 1 hit PF00096, zf-C2H2, 2 hits |
PIRSFi | PIRSF013212, PRDM1, 1 hit |
SMARTi | View protein in SMART SM00317, SET, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
s (5)i Sequence
Sequence statusi: Complete.
This entry describes 5 produced by isoformsialternative promoter usage and alternative splicing. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MREAYLRCWI FSWKNVWVRP CQRLHFKTVL LQGSLLYTAL DSYSTVQAAP
60 70 80 90 100
KSSSGSVKFQ GLAETGIMKM DMEDADMTLW TEAEFEEKCT YIVNDHPWDS
110 120 130 140 150
GADGGTSVQA EASLPRNLLF KYAANNSKEV IGVVSKEYIP KGTRFGPLIG
160 170 180 190 200
EVYTNDTVPK NANRKYFWRI YSREEFHHFI DGFNEEKSNW MRYVNPAHSA
210 220 230 240 250
REQNLAACQN GMNIYFYTIK PIPANQELLV WYCRDFAERL HYPYPGELTV
260 270 280 290 300
INLTQTESNP KQYSSEKNEL YPKSVPKREY SVKEILKLDS NPSKRKDIYR
310 320 330 340 350
SNISPFTLEK DMDGFRKNGS PDMPFYPRVV YPIRAPLPED FLKASLAYGM
360 370 380 390 400
ERPTYITHSP LPSSTTPSPP ASSSPEQSLK SSSPHSSPGN TVSPLAPGLP
410 420 430 440 450
EHRDSYSYLN VSYGSEGLGS YPGYAPAPHL PPAFIPSYNA HYPKFLLPPY
460 470 480 490 500
GISSNGLSTM NNINGINNFS LFPRLYPVYS NLLSGSSLPH PMLNPASLPS
510 520 530 540 550
SLPTDGARRL LPPEHPKEVL IPAPHSAFSL TGAAASMKDE SSPPSGSPTA
560 570 580 590 600
GTAATSEHVV QPKATSSVMA APSTDGAMNL IKNKRNMTGY KTLPYPLKKQ
610 620 630 640 650
NGKIKYECNV CAKTFGQLSN LKVHLRVHSG ERPFKCQTCN KGFTQLAHLQ
660 670 680 690 700
KHYLVHTGEK PHECQVCHKR FSSTSNLKTH LRLHSGEKPY QCKVCPAKFT
710 720 730 740 750
QFVHLKLHKR LHTRERPHKC AQCHKSYIHL CSLKVHLKGN CPAGPAAGLP
760 770 780 790 800
LEDLTRINEE IERFDISDNA DRLEDMEDSV DVTSMVEKEI LAVVRKEKEE
810 820 830 840 850
TSLKVSLQRN MGNGLLSSGC SLYESSDLSL MKLPHSNPLP LVPVKVKQET
VEPMDP
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 155 | N → K in AAI29802 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 205 | L → M in AK077622 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_041570 | 1 – 67 | Missing in isoform 3. 1 PublicationAdd BLAST | 67 | |
Alternative sequenceiVSP_039189 | 1 – 47 | MREAY…YSTVQ → MLDLLLEKRVGTTL in isoform 2. 2 PublicationsAdd BLAST | 47 | |
Alternative sequenceiVSP_041571 | 1 – 47 | MREAY…YSTVQ → MTPGVPGHRTQQRPQHISAL SDKAKDCSK in isoform 4. CuratedAdd BLAST | 47 | |
Alternative sequenceiVSP_041572 | 624 – 666 | Missing in isoform 5. CuratedAdd BLAST | 43 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08185 mRNA Translation: AAA19252.1 AF305539 , AF305534, AF305535, AF305536, AF305537, AF305538 Genomic DNA Translation: AAG42212.1 AK077622 mRNA No translation available. AK149344 mRNA Translation: BAE28822.1 BC129801 mRNA Translation: AAI29802.1 Different initiation. |
CCDSi | CCDS23825.2 [Q60636-2] |
PIRi | A53503 |
RefSeqi | NP_031574.2, NM_007548.4 [Q60636-2] XP_006512565.1, XM_006512502.3 [Q60636-4] XP_006512566.1, XM_006512503.2 [Q60636-3] XP_006512568.1, XM_006512505.2 [Q60636-1] XP_011241411.1, XM_011243109.1 [Q60636-3] |
Genome annotation databases
Ensembli | ENSMUST00000039174; ENSMUSP00000039248; ENSMUSG00000038151 [Q60636-1] ENSMUST00000105490; ENSMUSP00000101129; ENSMUSG00000038151 [Q60636-2] ENSMUST00000218369; ENSMUSP00000151237; ENSMUSG00000038151 [Q60636-4] |
GeneIDi | 12142 |
KEGGi | mmu:12142 |
UCSCi | uc007ezu.3, mouse [Q60636-1] uc007ezv.3, mouse [Q60636-2] |
Keywords - Coding sequence diversityi
Alternative promoter usage, Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08185 mRNA Translation: AAA19252.1 AF305539 , AF305534, AF305535, AF305536, AF305537, AF305538 Genomic DNA Translation: AAG42212.1 AK077622 mRNA No translation available. AK149344 mRNA Translation: BAE28822.1 BC129801 mRNA Translation: AAI29802.1 Different initiation. |
CCDSi | CCDS23825.2 [Q60636-2] |
PIRi | A53503 |
RefSeqi | NP_031574.2, NM_007548.4 [Q60636-2] XP_006512565.1, XM_006512502.3 [Q60636-4] XP_006512566.1, XM_006512503.2 [Q60636-3] XP_006512568.1, XM_006512505.2 [Q60636-1] XP_011241411.1, XM_011243109.1 [Q60636-3] |
3D structure databases
SMRi | Q60636 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198355, 9 interactors |
IntActi | Q60636, 1 interactor |
MINTi | Q60636 |
STRINGi | 10090.ENSMUSP00000101129 |
PTM databases
iPTMneti | Q60636 |
PhosphoSitePlusi | Q60636 |
Proteomic databases
MaxQBi | Q60636 |
PaxDbi | Q60636 |
PeptideAtlasi | Q60636 |
PRIDEi | Q60636 |
ProteomicsDBi | 291552 [Q60636-1] 291553 [Q60636-2] 291554 [Q60636-3] 291555 [Q60636-4] 291556 [Q60636-5] |
Protocols and materials databases
Antibodypediai | 19038, 678 antibodies from 39 providers |
DNASUi | 12142 |
Genome annotation databases
Ensembli | ENSMUST00000039174; ENSMUSP00000039248; ENSMUSG00000038151 [Q60636-1] ENSMUST00000105490; ENSMUSP00000101129; ENSMUSG00000038151 [Q60636-2] ENSMUST00000218369; ENSMUSP00000151237; ENSMUSG00000038151 [Q60636-4] |
GeneIDi | 12142 |
KEGGi | mmu:12142 |
UCSCi | uc007ezu.3, mouse [Q60636-1] uc007ezv.3, mouse [Q60636-2] |
Organism-specific databases
CTDi | 639 |
MGIi | MGI:99655, Prdm1 |
VEuPathDBi | HostDB:ENSMUSG00000038151 |
Phylogenomic databases
eggNOGi | KOG2461, Eukaryota |
GeneTreei | ENSGT00940000154798 |
HOGENOMi | CLU_007033_2_1_1 |
InParanoidi | Q60636 |
OMAi | WDCGADG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q60636 |
TreeFami | TF316545 |
Miscellaneous databases
BioGRID-ORCSi | 12142, 0 hits in 67 CRISPR screens |
ChiTaRSi | Prdm1, mouse |
PROi | PR:Q60636 |
RNActi | Q60636, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000038151, Expressed in testis and 229 other tissues |
Genevisiblei | Q60636, MM |
Family and domain databases
CDDi | cd19187, PR-SET_PRDM1, 1 hit |
InterProi | View protein in InterPro IPR016608, PRDM1 IPR044413, PRDM1_PR-SET IPR001214, SET_dom IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00856, SET, 1 hit PF00096, zf-C2H2, 2 hits |
PIRSFi | PIRSF013212, PRDM1, 1 hit |
SMARTi | View protein in SMART SM00317, SET, 1 hit SM00355, ZnF_C2H2, 5 hits |
SUPFAMi | SSF57667, SSF57667, 3 hits |
PROSITEi | View protein in PROSITE PS50280, SET, 1 hit PS00028, ZINC_FINGER_C2H2_1, 4 hits PS50157, ZINC_FINGER_C2H2_2, 4 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | PRDM1_MOUSE | |
Accessioni | Q60636Primary (citable) accession number: Q60636 Secondary accession number(s): A2VDE8, Q3UET9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 8, 2002 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 177 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families