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Protein

COUP transcription factor 1

Gene

Nr2f1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi82 – 157Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri85 – 105NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri121 – 145NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

  • cerebral cortex regionalization Source: MGI
  • forebrain development Source: MGI
  • negative regulation of neuron projection development Source: MGI
  • negative regulation of transcription by RNA polymerase II Source: MGI
  • nervous system development Source: MGI
  • neuron migration Source: MGI
  • positive regulation of production of miRNAs involved in gene silencing by miRNA Source: MGI
  • positive regulation of transcription by RNA polymerase II Source: MGI
  • regulation of gene expression Source: MGI
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, DNA-binding, Receptor, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
COUP transcription factor 1
Short name:
COUP-TF1
Alternative name(s):
COUP transcription factor I
Short name:
COUP-TF I
Nuclear receptor subfamily 2 group F member 1
V-erbA-related protein 3
Short name:
EAR-3
Gene namesi
Name:Nr2f1
Synonyms:Erbal3, Tfcoup1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1352451 Nr2f1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000536031 – 422COUP transcription factor 1Add BLAST422

Proteomic databases

MaxQBiQ60632
PaxDbiQ60632
PeptideAtlasiQ60632
PRIDEiQ60632

PTM databases

iPTMnetiQ60632
PhosphoSitePlusiQ60632

Expressioni

Developmental stagei

Expression begins in 8.5-day-old embryos, peaks at 14-15 days and declines before birth.

Gene expression databases

CleanExiMM_NR2F1

Interactioni

Subunit structurei

Binds DNA as a dimer; homodimer and probable heterodimer with NR2F6. Interacts with COPS2 (By similarity).By similarity

Protein-protein interaction databases

BioGridi199495, 1 interactor
STRINGi10090.ENSMUSP00000089036

Structurei

3D structure databases

ProteinModelPortaliQ60632
SMRiQ60632
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini183 – 409NR LBDPROSITE-ProRule annotationAdd BLAST227

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni343 – 422Important for dimerizationAdd BLAST80

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi32 – 38Poly-Gly7

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri85 – 105NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri121 – 145NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
HOGENOMiHOG000260820
HOVERGENiHBG005606
InParanoidiQ60632
KOiK08547
PhylomeDBiQ60632

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR003068 COUP_TF
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR01282 COUPTNFACTOR
PR00398 STRDHORMONER
PR00047 STROIDFINGER
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60632-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAMVVSSWRD PQDDVAGGNP GGPNPAAQAA RGGGGGAGEQ QQAGSGAPHT
60 70 80 90 100
PQTPGQPGAP ATPGTQGDKG QGPPGSGQSQ QHIECVVCGD KSSGKHYGQF
110 120 130 140 150
TCEGCKSFFK RSVRRNLTYT CRANRNCPID QHHRNQCQYC RLKKCLKVGM
160 170 180 190 200
RREAVQRGRM PPTQPNPGQY ALTNGDPLNG HCYLSGYISL LLRAEPYPTS
210 220 230 240 250
RYGSQCMQPN NIMGIENICE LAARLLFSAV EWARNIPFFP DLQITDQVSL
260 270 280 290 300
LRLTWSELFV LNAAQCSMPL HVAPLLAAAG LHASPMSADR VVAFMDHIRI
310 320 330 340 350
FQEQVEKLKA LHVDSAEYSC LKAIVLFTSD ACGLSDAAHI ESLQEKSQCA
360 370 380 390 400
LEEYVRSQYP NQPSRFGKLL LRLPSLRTVS SSVIEQLFFV RLVGKTPIET
410 420
LIRDMLLSGS SFNWPYMSIQ CS
Length:422
Mass (Da):46,085
Last modified:May 1, 1997 - v2
Checksum:iC16591638E1E2500
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 37Missing in AAA19853 (PubMed:7947324).Curated2
Sequence conflicti66Q → A in AAA19853 (PubMed:7947324).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07625 mRNA Translation: AAA19853.1
X74134 mRNA Translation: CAA52231.1
PIRiI48305
RefSeqiNP_034281.2, NM_010151.3
UniGeneiMm.439653

Genome annotation databases

GeneIDi13865
KEGGimmu:13865

Similar proteinsi

Entry informationi

Entry nameiCOT1_MOUSE
AccessioniPrimary (citable) accession number: Q60632
Secondary accession number(s): Q61438
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 1997
Last modified: June 20, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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