UniProtKB - Q60631 (GRB2_MOUSE)
Growth factor receptor-bound protein 2
Grb2
Functioni
GO - Molecular functioni
- enzyme binding Source: MGI
- ephrin receptor binding Source: UniProtKB
- epidermal growth factor receptor binding Source: MGI
- identical protein binding Source: MGI
- insulin receptor substrate binding Source: MGI
- neurotrophin TRKA receptor binding Source: MGI
- phosphoprotein binding Source: MGI
- phosphotyrosine residue binding Source: MGI
- protein-containing complex binding Source: MGI
- protein domain specific binding Source: MGI
- protein kinase binding Source: MGI
- protein-macromolecule adaptor activity Source: MGI
- protein phosphatase binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB
GO - Biological processi
- actin cytoskeleton reorganization Source: MGI
- aging Source: MGI
- anatomical structure formation involved in morphogenesis Source: MGI
- branching involved in labyrinthine layer morphogenesis Source: MGI
- cell differentiation Source: MGI
- cellular response to ionizing radiation Source: MGI
- epidermal growth factor receptor signaling pathway Source: MGI
- insulin receptor signaling pathway Source: MGI
- positive regulation of actin filament polymerization Source: MGI
- positive regulation of reactive oxygen species metabolic process Source: MGI
- Ras protein signal transduction Source: MGI
- receptor internalization Source: MGI
- regulation of MAPK cascade Source: MGI
- signal transduction in response to DNA damage Source: MGI
Enzyme and pathway databases
Reactomei | R-MMU-109704, PI3K Cascade R-MMU-112412, SOS-mediated signalling R-MMU-1250347, SHC1 events in ERBB4 signaling R-MMU-1257604, PIP3 activates AKT signaling R-MMU-1295596, Spry regulation of FGF signaling R-MMU-1433557, Signaling by SCF-KIT R-MMU-1433559, Regulation of KIT signaling R-MMU-167044, Signalling to RAS R-MMU-179812, GRB2 events in EGFR signaling R-MMU-180292, GAB1 signalosome R-MMU-180336, SHC1 events in EGFR signaling R-MMU-182971, EGFR downregulation R-MMU-186763, Downstream signal transduction R-MMU-1963640, GRB2 events in ERBB2 signaling R-MMU-1963642, PI3K events in ERBB2 signaling R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-210993, Tie2 Signaling R-MMU-2179392, EGFR Transactivation by Gastrin R-MMU-2424491, DAP12 signaling R-MMU-2428933, SHC-related events triggered by IGF1R R-MMU-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-MMU-2871796, FCERI mediated MAPK activation R-MMU-2871809, FCERI mediated Ca+2 mobilization R-MMU-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-MMU-375165, NCAM signaling for neurite out-growth R-MMU-388841, Costimulation by the CD28 family R-MMU-389359, CD28 dependent Vav1 pathway R-MMU-391160, Signal regulatory protein family interactions R-MMU-5654688, SHC-mediated cascade:FGFR1 R-MMU-5654689, PI-3K cascade:FGFR1 R-MMU-5654693, FRS-mediated FGFR1 signaling R-MMU-5654695, PI-3K cascade:FGFR2 R-MMU-5654699, SHC-mediated cascade:FGFR2 R-MMU-5654700, FRS-mediated FGFR2 signaling R-MMU-5654704, SHC-mediated cascade:FGFR3 R-MMU-5654706, FRS-mediated FGFR3 signaling R-MMU-5654710, PI-3K cascade:FGFR3 R-MMU-5654712, FRS-mediated FGFR4 signaling R-MMU-5654719, SHC-mediated cascade:FGFR4 R-MMU-5654720, PI-3K cascade:FGFR4 R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5654733, Negative regulation of FGFR4 signaling R-MMU-5663213, RHO GTPases Activate WASPs and WAVEs R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6807004, Negative regulation of MET activity R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-74749, Signal attenuation R-MMU-74751, Insulin receptor signalling cascade R-MMU-8851805, MET activates RAS signaling R-MMU-8851907, MET activates PI3K/AKT signaling R-MMU-8853659, RET signaling R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-8865999, MET activates PTPN11 R-MMU-8875555, MET activates RAP1 and RAC1 R-MMU-8875656, MET receptor recycling R-MMU-8983432, Interleukin-15 signaling R-MMU-9027284, Erythropoietin activates RAS R-MMU-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-MMU-912526, Interleukin receptor SHC signaling R-MMU-912631, Regulation of signaling by CBL R-MMU-9607240, FLT3 Signaling R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Names & Taxonomyi
Protein namesi | Recommended name: Growth factor receptor-bound protein 2Alternative name(s): Adapter protein GRB2 SH2/SH3 adapter GRB2 |
Gene namesi | Name:Grb2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:95805, Grb2 |
Subcellular locationi
Endosome
- Endosome By similarity
Golgi apparatus
- Golgi apparatus 1 Publication
Nucleus
- Nucleus By similarity
Other locations
- Cytoplasm By similarity
Cytosol
- cytosol Source: Reactome
Endosome
- endosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Nucleus
- COP9 signalosome Source: UniProtKB
- nucleolus Source: MGI
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
Plasma Membrane
- Grb2-EGFR complex Source: MGI
- plasma membrane Source: MGI
Other locations
- cell-cell junction Source: MGI
- cytoplasm Source: MGI
- membrane Source: MGI
- protein-containing complex Source: MGI
- vesicle membrane Source: MGI
Keywords - Cellular componenti
Cytoplasm, Endosome, Golgi apparatus, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000088199 | 1 – 217 | Growth factor receptor-bound protein 2Add BLAST | 217 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Modified residuei | 6 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 50 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 109 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 211 | PhosphothreonineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q60631 |
PaxDbi | Q60631 |
PeptideAtlasi | Q60631 |
PRIDEi | Q60631 |
PTM databases
iPTMneti | Q60631 |
PhosphoSitePlusi | Q60631 |
SwissPalmi | Q60631 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000059923, Expressed in ectoplacental cone and 313 other tissues |
ExpressionAtlasi | Q60631, baseline and differential |
Genevisiblei | Q60631, MM |
Interactioni
Subunit structurei
Associates (via SH2 domain) with activated EGF and PDGF receptors (tyrosine phosphorylated) (By similarity).
Interacts with PDGFRA (tyrosine phosphorylated); the interaction may be indirect (PubMed:8943348).
Interacts with IRS4 (when Tyr-phosphorylated) (PubMed:11113178). Also associates to other cellular Tyr-phosphorylated proteins such as SIT1, IRS1, SHC and LNK; probably via the concerted action of both its SH2 and SH3 domains (By similarity). It also seems to interact with RAS in the signaling pathway leading to DNA synthesis.
Interacts with SOS1 (By similarity).
Forms a complex with MUC1 and SOS1, through interaction of the SH3 domains with SOS1 and the SH2 domain with phosphorylated MUC1 (By similarity).
Interacts with phosphorylated MET (By similarity).
Interacts with phosphorylated TOM1L1 (PubMed:11711534).
Interacts with the phosphorylated C-terminus of SH2B2 (By similarity).
Interacts with phosphorylated SIT1, LAX1, LAT, LAT2 and LIME1 upon TCR and/or BCR activation (By similarity) (PubMed:16249387, PubMed:14610044, PubMed:15477350, PubMed:15477348, PubMed:22561606).
Interacts with NISCH, PTPNS1 and REPS2 (By similarity).
Interacts with syntrophin SNTA1 (PubMed:11551227).
Interacts (via SH3 domains) with REPS1 (PubMed:9395447).
Interacts (via SH3 domains) with PIK3C2B (By similarity).
Interacts with CBL and CBLB (By similarity).
Interacts with AJUBA and CLNK (PubMed:10330178, PubMed:11463797).
Interacts (via SH2 domain) with TEK/TIE2 (tyrosine phosphorylated) (PubMed:10521483).
Interacts with SHB, INPP5D/SHIP1, SKAP1 and SKAP2 (By similarity).
Interacts with PTPN11 (PubMed:8943348).
Interacts with PRNP (PubMed:11571277).
Interacts with RALGPS1 (By similarity).
Interacts also with HCST (PubMed:16582911).
Interacts with KDR (PubMed:16966330).
Interacts with FLT1 (tyrosine-phosphorylated) (PubMed:9722576).
Interacts with GAPT and PTPRE (By similarity).
Interacts (via SH2 domain) with KIF26A (By similarity).
Interacts (via SH3 2) with GAB2 (PubMed:10068651).
Interacts with ADAM15 (By similarity).
Interacts with THEMIS2 (PubMed:20644716).
Interacts (via SH2 domain) with AXL (phosphorylated) (By similarity).
Interacts (via SH2 domain) with KIT (phosphorylated) (PubMed:10377264).
Interacts with PTPRJ and BCR (By similarity).
Interacts with PTPN23 (By similarity).
Interacts with FLT4 (tyrosine phosphorylated) (By similarity).
Interacts with EPHB1 and SHC1; activates the MAPK/ERK cascade to regulate cell migration (PubMed:12925710).
Part of a complex including TNK2, GRB2 and one receptor tyrosine kinase (RTK) such as AXL and PDGFRL, in which GRB2 promotes RTK recruitment by TNK2 (By similarity).
Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated) (PubMed:9312046).
Interacts with ERBB4 (By similarity).
Interacts with NTRK1 (phosphorylated upon ligand-binding) (By similarity).
Interacts with PTK2/FAK1 (tyrosine phosphorylated) (PubMed:7997267).
Interacts with PTK2B/PYK2 (tyrosine phosphorylated) (By similarity).
Interacts (via SH2-domain) with SCIMP; this interaction is dependent on phosphorylation of SCIMP 'Tyr-58' (PubMed:21930792, PubMed:28098138, PubMed:28290451).
Interacts (via SH3 domains) with GAREM1 (via proline-rich domain and tyrosine phosphorylated); the interaction occurs upon EGF stimulation (By similarity).
Interacts with DAB2 (PubMed:9569023).
Interacts with TESPA1 (By similarity).
Interacts with THEMIS (PubMed:19597498, PubMed:19597497, PubMed:19805304, PubMed:22561606).
Interacts with PLCG1, LAT and THEMIS upon TCR activation in thymocytes; the association is weaker in the absence of TESPA1 (PubMed:22561606).
Interacts with CD28 (By similarity).
Interacts with RAB13; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA (PubMed:21543326).
Interacts with ASAP3 (phosphorylated form) (By similarity).
Interacts (via SH2 domain) with PTPRH (phosphorylated form) (PubMed:20398064).
Interacts with PTPRO (phosphorylated form) (PubMed:20398064).
Interacts with PTPRB (phosphorylated form) (PubMed:20398064).
Interacts (via SH3 domain 2) with PRR14 (via proline-rich region) (By similarity).
Interacts with DENND2B (By similarity).
Interacts with SPRY2 (By similarity).
By similarity32 PublicationsBinary interactionsi
Hide detailsQ60631
Isoform 1 [Q60631-1]
With | #Exp. | IntAct |
---|---|---|
Themis - isoform 1 [Q8BGW0-1] | 3 | EBI-15532571,EBI-15806957 |
GO - Molecular functioni
- enzyme binding Source: MGI
- ephrin receptor binding Source: UniProtKB
- epidermal growth factor receptor binding Source: MGI
- identical protein binding Source: MGI
- insulin receptor substrate binding Source: MGI
- neurotrophin TRKA receptor binding Source: MGI
- phosphoprotein binding Source: MGI
- phosphotyrosine residue binding Source: MGI
- protein domain specific binding Source: MGI
- protein kinase binding Source: MGI
- protein phosphatase binding Source: UniProtKB
- SH3 domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 200046, 77 interactors |
CORUMi | Q60631 |
DIPi | DIP-259N |
IntActi | Q60631, 77 interactors |
MINTi | Q60631 |
STRINGi | 10090.ENSMUSP00000021090 |
Chemistry databases
BindingDBi | Q60631 |
Miscellaneous databases
RNActi | Q60631, protein |
Structurei
Secondary structure
3D structure databases
SMRi | Q60631 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q60631 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 58 | SH3 1PROSITE-ProRule annotationAdd BLAST | 58 | |
Domaini | 60 – 152 | SH2PROSITE-ProRule annotationAdd BLAST | 93 | |
Domaini | 156 – 215 | SH3 2PROSITE-ProRule annotationAdd BLAST | 60 |
Domaini
Sequence similaritiesi
Keywords - Domaini
Repeat, SH2 domain, SH3 domainPhylogenomic databases
eggNOGi | KOG3601, Eukaryota |
GeneTreei | ENSGT00940000155738 |
InParanoidi | Q60631 |
OMAi | PATYVCP |
PhylomeDBi | Q60631 |
TreeFami | TF354288 |
Family and domain databases
CDDi | cd11949, SH3_GRB2_C, 1 hit cd11946, SH3_GRB2_N, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035643, GRB2_C_SH3 IPR035641, GRB2_N_SH3 IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MEAIAKYDFK ATADDELSFK RGDILKVLNE ECDQNWYKAE LNGKDGFIPK
60 70 80 90 100
NYIEMKPHPW FFGKIPRAKA EEMLSKQRHD GAFLIRESES APGDFSLSVK
110 120 130 140 150
FGNDVQHFKV LRDGAGKYFL WVVKFNSLNE LVDYHRSTSV SRNQQIFLRD
160 170 180 190 200
IEQMPQQPTY VQALFDFDPQ EDGELGFRRG DFIHVMDNSD PNWWKGACHG
210
QTGMFPRNYV TPVNRNV
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AT92 | B1AT92_MOUSE | Growth factor receptor-bound protei... | Grb2 | 203 | Annotation score: | ||
B1AT95 | B1AT95_MOUSE | Growth factor receptor-bound protei... | Grb2 | 71 | Annotation score: |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_001841 | 60 – 100 | Missing in isoform 2. 1 PublicationAdd BLAST | 41 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07617 mRNA Translation: AAB40022.1 D85748 mRNA Translation: BAA12862.1 BC052377 mRNA Translation: AAH52377.1 BC085254 mRNA Translation: AAH85254.1 |
CCDSi | CCDS25645.1 [Q60631-1] |
PIRi | A54688 |
RefSeqi | NP_001300865.1, NM_001313936.1 [Q60631-1] NP_001300866.1, NM_001313937.1 [Q60631-1] NP_032189.1, NM_008163.4 [Q60631-1] |
Genome annotation databases
Ensembli | ENSMUST00000021090; ENSMUSP00000021090; ENSMUSG00000059923 [Q60631-1] ENSMUST00000106497; ENSMUSP00000102106; ENSMUSG00000059923 [Q60631-1] ENSMUST00000106499; ENSMUSP00000102108; ENSMUSG00000059923 [Q60631-2] |
GeneIDi | 14784 |
KEGGi | mmu:14784 |
UCSCi | uc007mii.1, mouse [Q60631-2] uc007mij.1, mouse [Q60631-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Grb2 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U07617 mRNA Translation: AAB40022.1 D85748 mRNA Translation: BAA12862.1 BC052377 mRNA Translation: AAH52377.1 BC085254 mRNA Translation: AAH85254.1 |
CCDSi | CCDS25645.1 [Q60631-1] |
PIRi | A54688 |
RefSeqi | NP_001300865.1, NM_001313936.1 [Q60631-1] NP_001300866.1, NM_001313937.1 [Q60631-1] NP_032189.1, NM_008163.4 [Q60631-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1GBQ | NMR | - | A | 1-61 | [»] | |
1GBR | NMR | - | A | 1-59 | [»] | |
2GBQ | NMR | - | A | 1-59 | [»] | |
3GBQ | NMR | - | A | 1-59 | [»] | |
4GBQ | NMR | - | A | 1-59 | [»] | |
SMRi | Q60631 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 200046, 77 interactors |
CORUMi | Q60631 |
DIPi | DIP-259N |
IntActi | Q60631, 77 interactors |
MINTi | Q60631 |
STRINGi | 10090.ENSMUSP00000021090 |
Chemistry databases
BindingDBi | Q60631 |
ChEMBLi | CHEMBL4830 |
DrugCentrali | Q60631 |
PTM databases
iPTMneti | Q60631 |
PhosphoSitePlusi | Q60631 |
SwissPalmi | Q60631 |
Proteomic databases
EPDi | Q60631 |
PaxDbi | Q60631 |
PeptideAtlasi | Q60631 |
PRIDEi | Q60631 |
Protocols and materials databases
Antibodypediai | 3408, 659 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000021090; ENSMUSP00000021090; ENSMUSG00000059923 [Q60631-1] ENSMUST00000106497; ENSMUSP00000102106; ENSMUSG00000059923 [Q60631-1] ENSMUST00000106499; ENSMUSP00000102108; ENSMUSG00000059923 [Q60631-2] |
GeneIDi | 14784 |
KEGGi | mmu:14784 |
UCSCi | uc007mii.1, mouse [Q60631-2] uc007mij.1, mouse [Q60631-1] |
Organism-specific databases
CTDi | 2885 |
MGIi | MGI:95805, Grb2 |
Phylogenomic databases
eggNOGi | KOG3601, Eukaryota |
GeneTreei | ENSGT00940000155738 |
InParanoidi | Q60631 |
OMAi | PATYVCP |
PhylomeDBi | Q60631 |
TreeFami | TF354288 |
Enzyme and pathway databases
Reactomei | R-MMU-109704, PI3K Cascade R-MMU-112412, SOS-mediated signalling R-MMU-1250347, SHC1 events in ERBB4 signaling R-MMU-1257604, PIP3 activates AKT signaling R-MMU-1295596, Spry regulation of FGF signaling R-MMU-1433557, Signaling by SCF-KIT R-MMU-1433559, Regulation of KIT signaling R-MMU-167044, Signalling to RAS R-MMU-179812, GRB2 events in EGFR signaling R-MMU-180292, GAB1 signalosome R-MMU-180336, SHC1 events in EGFR signaling R-MMU-182971, EGFR downregulation R-MMU-186763, Downstream signal transduction R-MMU-1963640, GRB2 events in ERBB2 signaling R-MMU-1963642, PI3K events in ERBB2 signaling R-MMU-2029482, Regulation of actin dynamics for phagocytic cup formation R-MMU-210993, Tie2 Signaling R-MMU-2179392, EGFR Transactivation by Gastrin R-MMU-2424491, DAP12 signaling R-MMU-2428933, SHC-related events triggered by IGF1R R-MMU-2730905, Role of LAT2/NTAL/LAB on calcium mobilization R-MMU-2871796, FCERI mediated MAPK activation R-MMU-2871809, FCERI mediated Ca+2 mobilization R-MMU-354194, GRB2:SOS provides linkage to MAPK signaling for Integrins R-MMU-375165, NCAM signaling for neurite out-growth R-MMU-388841, Costimulation by the CD28 family R-MMU-389359, CD28 dependent Vav1 pathway R-MMU-391160, Signal regulatory protein family interactions R-MMU-5654688, SHC-mediated cascade:FGFR1 R-MMU-5654689, PI-3K cascade:FGFR1 R-MMU-5654693, FRS-mediated FGFR1 signaling R-MMU-5654695, PI-3K cascade:FGFR2 R-MMU-5654699, SHC-mediated cascade:FGFR2 R-MMU-5654700, FRS-mediated FGFR2 signaling R-MMU-5654704, SHC-mediated cascade:FGFR3 R-MMU-5654706, FRS-mediated FGFR3 signaling R-MMU-5654710, PI-3K cascade:FGFR3 R-MMU-5654712, FRS-mediated FGFR4 signaling R-MMU-5654719, SHC-mediated cascade:FGFR4 R-MMU-5654720, PI-3K cascade:FGFR4 R-MMU-5654726, Negative regulation of FGFR1 signaling R-MMU-5654727, Negative regulation of FGFR2 signaling R-MMU-5654732, Negative regulation of FGFR3 signaling R-MMU-5654733, Negative regulation of FGFR4 signaling R-MMU-5663213, RHO GTPases Activate WASPs and WAVEs R-MMU-5673001, RAF/MAP kinase cascade R-MMU-6807004, Negative regulation of MET activity R-MMU-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-MMU-74749, Signal attenuation R-MMU-74751, Insulin receptor signalling cascade R-MMU-8851805, MET activates RAS signaling R-MMU-8851907, MET activates PI3K/AKT signaling R-MMU-8853659, RET signaling R-MMU-8856825, Cargo recognition for clathrin-mediated endocytosis R-MMU-8856828, Clathrin-mediated endocytosis R-MMU-8865999, MET activates PTPN11 R-MMU-8875555, MET activates RAP1 and RAC1 R-MMU-8875656, MET receptor recycling R-MMU-8983432, Interleukin-15 signaling R-MMU-9027284, Erythropoietin activates RAS R-MMU-9028731, Activated NTRK2 signals through FRS2 and FRS3 R-MMU-912526, Interleukin receptor SHC signaling R-MMU-912631, Regulation of signaling by CBL R-MMU-9607240, FLT3 Signaling R-MMU-983695, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
Miscellaneous databases
BioGRID-ORCSi | 14784, 5 hits in 16 CRISPR screens |
ChiTaRSi | Grb2, mouse |
EvolutionaryTracei | Q60631 |
PROi | PR:Q60631 |
RNActi | Q60631, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000059923, Expressed in ectoplacental cone and 313 other tissues |
ExpressionAtlasi | Q60631, baseline and differential |
Genevisiblei | Q60631, MM |
Family and domain databases
CDDi | cd11949, SH3_GRB2_C, 1 hit cd11946, SH3_GRB2_N, 1 hit |
Gene3Di | 3.30.505.10, 1 hit |
InterProi | View protein in InterPro IPR035643, GRB2_C_SH3 IPR035641, GRB2_N_SH3 IPR000980, SH2 IPR036860, SH2_dom_sf IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00017, SH2, 1 hit PF00018, SH3_1, 2 hits |
PRINTSi | PR00401, SH2DOMAIN PR00452, SH3DOMAIN |
SMARTi | View protein in SMART SM00252, SH2, 1 hit SM00326, SH3, 2 hits |
SUPFAMi | SSF50044, SSF50044, 1 hit SSF55550, SSF55550, 1 hit |
PROSITEi | View protein in PROSITE PS50001, SH2, 1 hit PS50002, SH3, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GRB2_MOUSE | |
Accessioni | Q60631Primary (citable) accession number: Q60631 Secondary accession number(s): Q61240 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 217 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families