UniProtKB - Q60625 (ICAM5_MOUSE)
Protein
Intercellular adhesion molecule 5
Gene
Icam5
Organism
Mus musculus (Mouse)
Status
Functioni
ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).1 Publication
GO - Molecular functioni
- integrin binding Source: GO_Central
GO - Biological processi
- cell adhesion Source: GO_Central
- cell-cell adhesion Source: InterPro
- phagocytosis Source: MGI
Keywordsi
Biological process | Cell adhesion |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-216083, Integrin cell surface interactions |
Names & Taxonomyi
Protein namesi | Recommended name: Intercellular adhesion molecule 5Short name: ICAM-5 Alternative name(s): Telencephalin |
Gene namesi | Name:Icam5 Synonyms:Icam3, Tlcn |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109430, Icam5 |
Subcellular locationi
Other locations
- Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 32 – 833 | ExtracellularSequence analysisAdd BLAST | 802 | |
Transmembranei | 834 – 854 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 855 – 917 | CytoplasmicSequence analysisAdd BLAST | 63 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 54 | N → Q: Fails to form disulfide bonds and to induce filopodia-like protrusions. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 31 | Sequence analysisAdd BLAST | 31 | |
ChainiPRO_0000014800 | 32 – 917 | Intercellular adhesion molecule 5Add BLAST | 886 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 54 | N-linked (GlcNAc...) (high mannose) asparagine1 Publication | 1 | |
Disulfide bondi | 55 ↔ 99 | PROSITE-ProRule annotation | ||
Disulfide bondi | 59 ↔ 103 | PROSITE-ProRule annotation | ||
Glycosylationi | 74 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 137 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 142 ↔ 198 | PROSITE-ProRule annotation | ||
Modified residuei | 182 | PhosphothreonineBy similarity | 1 | |
Glycosylationi | 195 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 214 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 249 ↔ 302 | PROSITE-ProRule annotation | ||
Glycosylationi | 274 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 316 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 344 ↔ 383 | PROSITE-ProRule annotation | ||
Glycosylationi | 371 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 397 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 415 ↔ 470 | PROSITE-ProRule annotation | ||
Disulfide bondi | 498 ↔ 551 | PROSITE-ProRule annotation | ||
Disulfide bondi | 579 ↔ 644 | PROSITE-ProRule annotation | ||
Glycosylationi | 582 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 645 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 672 ↔ 724 | PROSITE-ProRule annotation | ||
Glycosylationi | 762 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 767 ↔ 812 | PROSITE-ProRule annotation | ||
Glycosylationi | 793 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 794 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylation at Asn-54 is critical for functional folding.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | Q60625 |
PeptideAtlasi | Q60625 |
PRIDEi | Q60625 |
PTM databases
CarbonylDBi | Q60625 |
GlyConnecti | 2409, 15 N-Linked glycans (10 sites) |
GlyGeni | Q60625, 14 sites |
iPTMneti | Q60625 |
PhosphoSitePlusi | Q60625 |
Expressioni
Tissue specificityi
Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000032174, Expressed in dentate gyrus of hippocampal formation and 82 other tissues |
Genevisiblei | Q60625, MM |
Interactioni
GO - Molecular functioni
- integrin binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 200503, 4 interactors |
IntActi | Q60625, 5 interactors |
MINTi | Q60625 |
STRINGi | 10090.ENSMUSP00000019616 |
Miscellaneous databases
RNActi | Q60625, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 48 – 130 | Ig-like C2-type 1Add BLAST | 83 | |
Domaini | 135 – 235 | Ig-like C2-type 2Add BLAST | 101 | |
Domaini | 242 – 329 | Ig-like C2-type 3Add BLAST | 88 | |
Domaini | 337 – 402 | Ig-like C2-type 4Add BLAST | 66 | |
Domaini | 408 – 486 | Ig-like C2-type 5Add BLAST | 79 | |
Domaini | 491 – 567 | Ig-like C2-type 6Add BLAST | 77 | |
Domaini | 572 – 651 | Ig-like C2-type 7Add BLAST | 80 | |
Domaini | 665 – 738 | Ig-like C2-type 8Add BLAST | 74 | |
Domaini | 745 – 828 | Ig-like C2-type 9Add BLAST | 84 |
Sequence similaritiesi
Keywords - Domaini
Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QS16, Eukaryota |
GeneTreei | ENSGT00940000162184 |
HOGENOMi | CLU_014560_0_0_1 |
InParanoidi | Q60625 |
OMAi | PGIYVCN |
OrthoDBi | 731140at2759 |
TreeFami | TF333745 |
Family and domain databases
Gene3Di | 2.60.40.10, 9 hits |
InterProi | View protein in InterPro IPR003988, ICAM IPR013768, ICAM_N IPR003987, ICAM_VCAM_N IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF03921, ICAM_N, 1 hit |
PRINTSi | PR01473, ICAM PR01472, ICAMVCAM1 |
SMARTi | View protein in SMART SM00409, IG, 6 hits SM00408, IGc2, 4 hits |
SUPFAMi | SSF48726, SSF48726, 9 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q60625-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPGPSPGLRR ALLGLWAALG LGILGISAVA LEPFWADLQP RVALVERGGS
60 70 80 90 100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF
110 120 130 140 150
FRCARRTLQA RGLIRTFQRP DRVELVPLPS WQPVGENFTL SCRVPGAGPR
160 170 180 190 200
ASLTLTLLRG GQELIRRSFV GEPPRARGAM LTARVLARRE DHRVNFSCLA
210 220 230 240 250
ELDLRPHGLG LFANSSAPRQ LRTFAMPPHS PSLIAPRVLE VDSERPVTCT
260 270 280 290 300
LDGLFPAPEA GVYLSLGDQR LNPNVTLDGD SLVATATATA SAEQEGTKQL
310 320 330 340 350
MCVVTLGGES RETQENLTVY SFPTPLLTLS EPEAPEGKMV TISCWAGARA
360 370 380 390 400
LVTLEGIPAA VPGQPAELQL NVTKNDDKRG FFCDAALDVD GETLRKNQSS
410 420 430 440 450
ELRVLYAPRL DDLDCPRSWT WPEGPEQTLH CEARGNPEPS VHCARPEGGA
460 470 480 490 500
VLALGLLGPV TRALAGTYRC TAVNGQGQAV KDVTLTVEYA PALDSVGCPE
510 520 530 540 550
HITWLEGTEA SLSCVAHGVP PPSVSCVRSG KEEVMEGPLR VAREHAGTYR
560 570 580 590 600
CEAINARGSA AKNVAVTVEY GPSFEELGCP SNWTWVEGSG KLFSCEVDGK
610 620 630 640 650
PEPRVECVGS EGASEGIVLP LVSSNSGPRN SMTPGNLSPG IYLCNATNRH
660 670 680 690 700
GSTVKTVVVS AESPPQMDES SCPSHQTWLE GAEATALACS ARGRPSPRVH
710 720 730 740 750
CSREGAARLE RLQVSREDAG TYRCVATNAH GTDSRTVTVG VEYRPVVAEL
760 770 780 790 800
AASPPSVRPG GNFTLTCRAE AWPPAQISWR APPGALNLGL SSNNSTLSVA
810 820 830 840 850
GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLWVAVGG AAGGAALLAA
860 870 880 890 900
GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGTPG AEGGAETPGT
910
AESPADGEVF AIQLTSS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | R → P in AAA67204 (PubMed:7794412).Curated | 1 | |
Sequence conflicti | 310 | S → T in AAA67204 (PubMed:7794412).Curated | 1 | |
Sequence conflicti | 517 | H → P in AAA67204 (PubMed:7794412).Curated | 1 | |
Sequence conflicti | 649 | R → Q in BAE22394 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 664 | P → R in BAE22394 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 859 | Q → L in AAI13141 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06483 mRNA Translation: AAA67204.1 AK135040 mRNA Translation: BAE22394.1 AC159314 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25153.1 BC113140 mRNA Translation: AAI13141.1 U89893 Genomic DNA Translation: AAC53308.1 |
CCDSi | CCDS22891.1 |
PIRi | I48950 |
RefSeqi | NP_032345.2, NM_008319.2 |
Genome annotation databases
Ensembli | ENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174 |
GeneIDi | 15898 |
KEGGi | mmu:15898 |
UCSCi | uc009oka.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U06483 mRNA Translation: AAA67204.1 AK135040 mRNA Translation: BAE22394.1 AC159314 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25153.1 BC113140 mRNA Translation: AAI13141.1 U89893 Genomic DNA Translation: AAC53308.1 |
CCDSi | CCDS22891.1 |
PIRi | I48950 |
RefSeqi | NP_032345.2, NM_008319.2 |
3D structure databases
SMRi | Q60625 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200503, 4 interactors |
IntActi | Q60625, 5 interactors |
MINTi | Q60625 |
STRINGi | 10090.ENSMUSP00000019616 |
PTM databases
CarbonylDBi | Q60625 |
GlyConnecti | 2409, 15 N-Linked glycans (10 sites) |
GlyGeni | Q60625, 14 sites |
iPTMneti | Q60625 |
PhosphoSitePlusi | Q60625 |
Proteomic databases
PaxDbi | Q60625 |
PeptideAtlasi | Q60625 |
PRIDEi | Q60625 |
Protocols and materials databases
Antibodypediai | 2298, 270 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174 |
GeneIDi | 15898 |
KEGGi | mmu:15898 |
UCSCi | uc009oka.2, mouse |
Organism-specific databases
CTDi | 7087 |
MGIi | MGI:109430, Icam5 |
Phylogenomic databases
eggNOGi | ENOG502QS16, Eukaryota |
GeneTreei | ENSGT00940000162184 |
HOGENOMi | CLU_014560_0_0_1 |
InParanoidi | Q60625 |
OMAi | PGIYVCN |
OrthoDBi | 731140at2759 |
TreeFami | TF333745 |
Enzyme and pathway databases
Reactomei | R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-216083, Integrin cell surface interactions |
Miscellaneous databases
BioGRID-ORCSi | 15898, 0 hits in 17 CRISPR screens |
ChiTaRSi | Icam5, mouse |
PROi | PR:Q60625 |
RNActi | Q60625, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000032174, Expressed in dentate gyrus of hippocampal formation and 82 other tissues |
Genevisiblei | Q60625, MM |
Family and domain databases
Gene3Di | 2.60.40.10, 9 hits |
InterProi | View protein in InterPro IPR003988, ICAM IPR013768, ICAM_N IPR003987, ICAM_VCAM_N IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub IPR003598, Ig_sub2 |
Pfami | View protein in Pfam PF03921, ICAM_N, 1 hit |
PRINTSi | PR01473, ICAM PR01472, ICAMVCAM1 |
SMARTi | View protein in SMART SM00409, IG, 6 hits SM00408, IGc2, 4 hits |
SUPFAMi | SSF48726, SSF48726, 9 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 4 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ICAM5_MOUSE | |
Accessioni | Q60625Primary (citable) accession number: Q60625 Secondary accession number(s): G5E826, Q2KHL7, Q3UY19 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 18, 2001 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 162 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families