Icam5

Functionⁱ

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).1 Publication

GO - Molecular functionⁱ

integrin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell adhesion
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cell-cell adhesion Source: InterPro
phagocytosis
Source: MGI
Inferred from direct assayⁱ
- 15452145

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Cell adhesion

Biological process

Cell adhesion

Enzyme and pathway databases

Reactomeⁱ	R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-216083 Integrin cell surface interactions

Reactomeⁱ

R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083 Integrin cell surface interactions

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Intercellular adhesion molecule 5 Short name: ICAM-5 Alternative name(s): Telencephalin
Gene namesⁱ	Name:Icam5 Synonyms:Icam3, Tlcn
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 9

Organism-specific databases

MGIⁱ	MGI:109430 Icam5

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	32 – 833	ExtracellularSequence analysisAdd BLAST	802
Transmembraneⁱ	834 – 854	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	855 – 917	CytoplasmicSequence analysisAdd BLAST	63

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	54	N → Q: Fails to form disulfide bonds and to induce filopodia-like protrusions. 1 Publication		1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 31	Sequence analysisAdd BLAST		31
ChainⁱPRO_0000014800	32 – 917	Intercellular adhesion molecule 5Add BLAST		886

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	54	N-linked (GlcNAc...) (high mannose) asparagine1 Publication	1
Disulfide bondⁱ	55 ↔ 99	PROSITE-ProRule annotation
Disulfide bondⁱ	59 ↔ 103	PROSITE-ProRule annotation
Glycosylationⁱ	74	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	137	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	142 ↔ 198	PROSITE-ProRule annotation
Modified residueⁱ	182	PhosphothreonineBy similarity	1
Glycosylationⁱ	195	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	214	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	249 ↔ 302	PROSITE-ProRule annotation
Glycosylationⁱ	274	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	316	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	344 ↔ 383	PROSITE-ProRule annotation
Glycosylationⁱ	371	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	397	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	415 ↔ 470	PROSITE-ProRule annotation
Disulfide bondⁱ	498 ↔ 551	PROSITE-ProRule annotation
Disulfide bondⁱ	579 ↔ 644	PROSITE-ProRule annotation
Glycosylationⁱ	582	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	645	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	672 ↔ 724	PROSITE-ProRule annotation
Glycosylationⁱ	762	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	767 ↔ 812	PROSITE-ProRule annotation
Glycosylationⁱ	793	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	794	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Glycosylation at Asn-54 is critical for functional folding.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q60625
PeptideAtlas More...PeptideAtlasⁱ	Q60625
PRIDEⁱ	Q60625

PTM databases

CarbonylDBⁱ	Q60625
iPTMnetⁱ	Q60625
PhosphoSitePlusⁱ	Q60625

Expressionⁱ

Tissue specificityⁱ

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000032174 Expressed in 55 organ(s), highest expression level in dentate gyrus of hippocampal formation
CleanExⁱ	MM_ICAM5
Genevisibleⁱ	Q60625 MM

Interactionⁱ

GO - Molecular functionⁱ

integrin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	200503, 3 interactors
IntActⁱ	Q60625, 5 interactors
Molecular INTeraction database More...MINTⁱ	Q60625
STRINGⁱ	10090.ENSMUSP00000019616

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q60625
SMRⁱ	Q60625
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	48 – 130	Ig-like C2-type 1Add BLAST	83
Domainⁱ	135 – 235	Ig-like C2-type 2Add BLAST	101
Domainⁱ	242 – 329	Ig-like C2-type 3Add BLAST	88
Domainⁱ	337 – 402	Ig-like C2-type 4Add BLAST	66
Domainⁱ	408 – 486	Ig-like C2-type 5Add BLAST	79
Domainⁱ	491 – 567	Ig-like C2-type 6Add BLAST	77
Domainⁱ	572 – 651	Ig-like C2-type 7Add BLAST	80
Domainⁱ	665 – 738	Ig-like C2-type 8Add BLAST	74
Domainⁱ	745 – 828	Ig-like C2-type 9Add BLAST	84

Sequence similaritiesⁱ

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domainⁱ

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IPHM Eukaryota ENOG410YQ1Q LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063246
HOGENOMⁱ	HOG000168514
HOVERGENⁱ	HBG052077
InParanoidⁱ	Q60625
KEGG Orthology (KO) More...KOⁱ	K06769
OMAⁱ	PSCPSNW
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G022Y
TreeFamⁱ	TF333745

Family and domain databases

Gene3Dⁱ	2.60.40.10, 9 hits
InterProⁱ	View protein in InterPro IPR003988 ICAM IPR013768 ICAM_N IPR003987 ICAM_VCAM_N IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03921 ICAM_N, 1 hit
PRINTSⁱ	PR01473 ICAM PR01472 ICAMVCAM1
SMARTⁱ	View protein in SMART SM00409 IG, 6 hits SM00408 IGc2, 4 hits
SUPFAMⁱ	SSF48726 SSF48726, 9 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q60625-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPGPSPGLRR ALLGLWAALG LGILGISAVA LEPFWADLQP RVALVERGGS 
        60         70         80         90        100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF 
       110        120        130        140        150
FRCARRTLQA RGLIRTFQRP DRVELVPLPS WQPVGENFTL SCRVPGAGPR 
       160        170        180        190        200
ASLTLTLLRG GQELIRRSFV GEPPRARGAM LTARVLARRE DHRVNFSCLA 
       210        220        230        240        250
ELDLRPHGLG LFANSSAPRQ LRTFAMPPHS PSLIAPRVLE VDSERPVTCT 
       260        270        280        290        300
LDGLFPAPEA GVYLSLGDQR LNPNVTLDGD SLVATATATA SAEQEGTKQL 
       310        320        330        340        350
MCVVTLGGES RETQENLTVY SFPTPLLTLS EPEAPEGKMV TISCWAGARA 
       360        370        380        390        400
LVTLEGIPAA VPGQPAELQL NVTKNDDKRG FFCDAALDVD GETLRKNQSS 
       410        420        430        440        450
ELRVLYAPRL DDLDCPRSWT WPEGPEQTLH CEARGNPEPS VHCARPEGGA 
       460        470        480        490        500
VLALGLLGPV TRALAGTYRC TAVNGQGQAV KDVTLTVEYA PALDSVGCPE 
       510        520        530        540        550
HITWLEGTEA SLSCVAHGVP PPSVSCVRSG KEEVMEGPLR VAREHAGTYR 
       560        570        580        590        600
CEAINARGSA AKNVAVTVEY GPSFEELGCP SNWTWVEGSG KLFSCEVDGK 
       610        620        630        640        650
PEPRVECVGS EGASEGIVLP LVSSNSGPRN SMTPGNLSPG IYLCNATNRH 
       660        670        680        690        700
GSTVKTVVVS AESPPQMDES SCPSHQTWLE GAEATALACS ARGRPSPRVH 
       710        720        730        740        750
CSREGAARLE RLQVSREDAG TYRCVATNAH GTDSRTVTVG VEYRPVVAEL 
       760        770        780        790        800
AASPPSVRPG GNFTLTCRAE AWPPAQISWR APPGALNLGL SSNNSTLSVA 
       810        820        830        840        850
GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLWVAVGG AAGGAALLAA 
       860        870        880        890        900
GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGTPG AEGGAETPGT 
       910 
AESPADGEVF AIQLTSS

Length:917

Mass (Da):96,946

Last modified:October 3, 2012 - v2

Checksum:ⁱC2E98892A190F59C

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	47	R → P in AAA67204 (PubMed:7794412).Curated	1
Sequence conflictⁱ	310	S → T in AAA67204 (PubMed:7794412).Curated	1
Sequence conflictⁱ	517	H → P in AAA67204 (PubMed:7794412).Curated	1
Sequence conflictⁱ	649	R → Q in BAE22394 (PubMed:16141072).Curated	1
Sequence conflictⁱ	664	P → R in BAE22394 (PubMed:16141072).Curated	1
Sequence conflictⁱ	859	Q → L in AAI13141 (PubMed:15489334).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U06483 mRNA Translation: AAA67204.1 AK135040 mRNA Translation: BAE22394.1 AC159314 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25153.1 BC113140 mRNA Translation: AAI13141.1 U89893 Genomic DNA Translation: AAC53308.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22891.1
PIRⁱ	I48950
NCBI Reference Sequences More...RefSeqⁱ	NP_032345.2, NM_008319.2
UniGeneⁱ	Mm.4629

Genome annotation databases

Ensemblⁱ	ENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174
GeneIDⁱ	15898
KEGGⁱ	mmu:15898
UCSC genome browser More...UCSCⁱ	uc009oka.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q60625	Intercellular adhesion molecule 5		RAT		917	UniRef90_Q60625
intercellular adhesion molecule 5		MESAU		917
UPI00038BCC73		MICOH		917
UPI000A312BEE		MUSPA		917
UPI000A318D4B		MUSCR		917
+3

Protein	Similar proteins		Species	Score	Length	Source
Q60625	Intercellular adhesion molecule 5	)	HUMAN		924	UniRef50_Q9UMF0
Intercellular adhesion molecule 5		RABIT		912
Uncharacterized protein		AOTNA		931
Uncharacterized protein		PAPAN		925
Uncharacterized protein		MACNE		925
+149

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U06483 mRNA Translation: AAA67204.1 AK135040 mRNA Translation: BAE22394.1 AC159314 Genomic DNA No translation available. CH466522 Genomic DNA Translation: EDL25153.1 BC113140 mRNA Translation: AAI13141.1 U89893 Genomic DNA Translation: AAC53308.1
CCDSⁱ	CCDS22891.1
PIRⁱ	I48950
RefSeqⁱ	NP_032345.2, NM_008319.2
UniGeneⁱ	Mm.4629

3D structure databases

ProteinModelPortalⁱ	Q60625
SMRⁱ	Q60625
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	200503, 3 interactors
IntActⁱ	Q60625, 5 interactors
MINTⁱ	Q60625
STRINGⁱ	10090.ENSMUSP00000019616

PTM databases

CarbonylDBⁱ	Q60625
iPTMnetⁱ	Q60625
PhosphoSitePlusⁱ	Q60625

Proteomic databases

PaxDbⁱ	Q60625
PeptideAtlasⁱ	Q60625
PRIDEⁱ	Q60625

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174
GeneIDⁱ	15898
KEGGⁱ	mmu:15898
UCSCⁱ	uc009oka.2 mouse

Organism-specific databases

CTDⁱ	7087
MGIⁱ	MGI:109430 Icam5

Phylogenomic databases

eggNOGⁱ	ENOG410IPHM Eukaryota ENOG410YQ1Q LUCA
GeneTreeⁱ	ENSGT00530000063246
HOGENOMⁱ	HOG000168514
HOVERGENⁱ	HBG052077
InParanoidⁱ	Q60625
KOⁱ	K06769
OMAⁱ	PSCPSNW
OrthoDBⁱ	EOG091G022Y
TreeFamⁱ	TF333745

Enzyme and pathway databases

Reactomeⁱ	R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell R-MMU-216083 Integrin cell surface interactions

Reactomeⁱ

R-MMU-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083 Integrin cell surface interactions

Miscellaneous databases

ChiTaRSⁱ	Icam5 mouse
Protein Ontology More...PROⁱ	PR:Q60625
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000032174 Expressed in 55 organ(s), highest expression level in dentate gyrus of hippocampal formation
CleanExⁱ	MM_ICAM5
Genevisibleⁱ	Q60625 MM

Family and domain databases

Gene3Dⁱ	2.60.40.10, 9 hits
InterProⁱ	View protein in InterPro IPR003988 ICAM IPR013768 ICAM_N IPR003987 ICAM_VCAM_N IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR003599 Ig_sub IPR003598 Ig_sub2
Pfamⁱ	View protein in Pfam PF03921 ICAM_N, 1 hit
PRINTSⁱ	PR01473 ICAM PR01472 ICAMVCAM1
SMARTⁱ	View protein in SMART SM00409 IG, 6 hits SM00408 IGc2, 4 hits
SUPFAMⁱ	SSF48726 SSF48726, 9 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ICAM5_MOUSE
Accessionⁱ	Q60625Primary (citable) accession number: Q60625 Secondary accession number(s): G5E826, Q2KHL7, Q3UY19
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 18, 2001
	Last sequence update:	October 3, 2012
	Last modified:	September 12, 2018
	This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q60625 (ICAM5_MOUSE)

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Intercellular adhesion molecule 5

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Plasma Membrane

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ