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UniProtKB - Q60625 (ICAM5_MOUSE)

Entry version 165 (29 Sep 2021)
Sequence version 2 (03 Oct 2012)
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Protein

Intercellular adhesion molecule 5

Gene

Icam5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2).

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • integrin binding Source: GO_Central
Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processCell adhesion

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083, Integrin cell surface interactions

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Intercellular adhesion molecule 5
Short name:
ICAM-5
Alternative name(s):
Telencephalin
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Icam5
Synonyms:Icam3, Tlcn
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:109430, Icam5

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000032174

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini32 – 833ExtracellularSequence analysisAdd BLAST802
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei834 – 854HelicalSequence analysisAdd BLAST21
Topological domaini855 – 917CytoplasmicSequence analysisAdd BLAST63

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi54N → Q: Fails to form disulfide bonds and to induce filopodia-like protrusions. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001480032 – 917Intercellular adhesion molecule 5Add BLAST886

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi54N-linked (GlcNAc...) (high mannose) asparagine1 Publication1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 99PROSITE-ProRule annotation
Disulfide bondi59 ↔ 103PROSITE-ProRule annotation
Glycosylationi74N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi142 ↔ 198PROSITE-ProRule annotation
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei182PhosphothreonineBy similarity1
Glycosylationi195N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi214N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi249 ↔ 302PROSITE-ProRule annotation
Glycosylationi274N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi316N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi344 ↔ 383PROSITE-ProRule annotation
Glycosylationi371N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi397N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi415 ↔ 470PROSITE-ProRule annotation
Disulfide bondi498 ↔ 551PROSITE-ProRule annotation
Disulfide bondi579 ↔ 644PROSITE-ProRule annotation
Glycosylationi582N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi645N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi672 ↔ 724PROSITE-ProRule annotation
Glycosylationi762N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi767 ↔ 812PROSITE-ProRule annotation
Glycosylationi793N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi794N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Glycosylation at Asn-54 is critical for functional folding.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q60625

PeptideAtlas

More...PeptideAtlasi		Q60625

PRoteomics IDEntifications database

More...PRIDEi		Q60625

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		267086

PTM databases

CarbonylDB database of protein carbonylation sites

More...CarbonylDBi		Q60625

GlyConnect protein glycosylation platform

More...GlyConnecti		2409, 15 N-Linked glycans (10 sites)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q60625, 14 sites, 15 N-linked glycans (10 sites)

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q60625

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q60625

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed on neurons in the most rostral segment of the mammalian brain, the telencephalon.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000032174, Expressed in dentate gyrus of hippocampal formation and 94 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q60625, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		200503, 4 interactors

Protein interaction database and analysis system

More...IntActi		Q60625, 4 interactors

Molecular INTeraction database

More...MINTi		Q60625

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000019616

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q60625, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q60625

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini48 – 130Ig-like C2-type 1Add BLAST83
Domaini135 – 235Ig-like C2-type 2Add BLAST101
Domaini242 – 329Ig-like C2-type 3Add BLAST88
Domaini337 – 402Ig-like C2-type 4Add BLAST66
Domaini408 – 486Ig-like C2-type 5Add BLAST79
Domaini491 – 567Ig-like C2-type 6Add BLAST77
Domaini572 – 651Ig-like C2-type 7Add BLAST80
Domaini665 – 738Ig-like C2-type 8Add BLAST74
Domaini745 – 828Ig-like C2-type 9Add BLAST84

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni884 – 908DisorderedSequence analysisAdd BLAST25

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the immunoglobulin superfamily. ICAM family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QS16, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000162184

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_014560_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q60625

Identification of Orthologs from Complete Genome Data

More...OMAi		PGIYVCN

Database of Orthologous Groups

More...OrthoDBi		731140at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q60625

TreeFam database of animal gene trees

More...TreeFami		TF333745

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.40.10, 9 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003988, ICAM
IPR013768, ICAM_N
IPR003987, ICAM_VCAM_N
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03921, ICAM_N, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01473, ICAM
PR01472, ICAMVCAM1

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409, IG, 6 hits
SM00408, IGc2, 4 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48726, SSF48726, 9 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835, IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q60625-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPGPSPGLRR ALLGLWAALG LGILGISAVA LEPFWADLQP RVALVERGGS 
        60         70         80         90        100
LWLNCSTNCP RPERGGLETS LRRNGTQRGL RWLARQLVDI REPETQPVCF 
       110        120        130        140        150
FRCARRTLQA RGLIRTFQRP DRVELVPLPS WQPVGENFTL SCRVPGAGPR 
       160        170        180        190        200
ASLTLTLLRG GQELIRRSFV GEPPRARGAM LTARVLARRE DHRVNFSCLA 
       210        220        230        240        250
ELDLRPHGLG LFANSSAPRQ LRTFAMPPHS PSLIAPRVLE VDSERPVTCT 
       260        270        280        290        300
LDGLFPAPEA GVYLSLGDQR LNPNVTLDGD SLVATATATA SAEQEGTKQL 
       310        320        330        340        350
MCVVTLGGES RETQENLTVY SFPTPLLTLS EPEAPEGKMV TISCWAGARA 
       360        370        380        390        400
LVTLEGIPAA VPGQPAELQL NVTKNDDKRG FFCDAALDVD GETLRKNQSS 
       410        420        430        440        450
ELRVLYAPRL DDLDCPRSWT WPEGPEQTLH CEARGNPEPS VHCARPEGGA 
       460        470        480        490        500
VLALGLLGPV TRALAGTYRC TAVNGQGQAV KDVTLTVEYA PALDSVGCPE 
       510        520        530        540        550
HITWLEGTEA SLSCVAHGVP PPSVSCVRSG KEEVMEGPLR VAREHAGTYR 
       560        570        580        590        600
CEAINARGSA AKNVAVTVEY GPSFEELGCP SNWTWVEGSG KLFSCEVDGK 
       610        620        630        640        650
PEPRVECVGS EGASEGIVLP LVSSNSGPRN SMTPGNLSPG IYLCNATNRH 
       660        670        680        690        700
GSTVKTVVVS AESPPQMDES SCPSHQTWLE GAEATALACS ARGRPSPRVH 
       710        720        730        740        750
CSREGAARLE RLQVSREDAG TYRCVATNAH GTDSRTVTVG VEYRPVVAEL 
       760        770        780        790        800
AASPPSVRPG GNFTLTCRAE AWPPAQISWR APPGALNLGL SSNNSTLSVA 
       810        820        830        840        850
GAMGSHGGEY ECAATNAHGR HARRITVRVA GPWLWVAVGG AAGGAALLAA 
       860        870        880        890        900
GAGLAFYVQS TACKKGEYNV QEAESSGEAV CLNGAGGTPG AEGGAETPGT 
       910 
AESPADGEVF AIQLTSS
Length:917
Mass (Da):96,946
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC2E98892A190F59C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti47R → P in AAA67204 (PubMed:7794412).Curated1
Sequence conflicti310S → T in AAA67204 (PubMed:7794412).Curated1
Sequence conflicti517H → P in AAA67204 (PubMed:7794412).Curated1
Sequence conflicti649R → Q in BAE22394 (PubMed:16141072).Curated1
Sequence conflicti664P → R in BAE22394 (PubMed:16141072).Curated1
Sequence conflicti859Q → L in AAI13141 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U06483 mRNA Translation: AAA67204.1
AK135040 mRNA Translation: BAE22394.1
AC159314 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25153.1
BC113140 mRNA Translation: AAI13141.1
U89893 Genomic DNA Translation: AAC53308.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS22891.1

Protein sequence database of the Protein Information Resource

More...PIRi		I48950

NCBI Reference Sequences

More...RefSeqi		NP_032345.2, NM_008319.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174

Database of genes from NCBI RefSeq genomes

More...GeneIDi		15898

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:15898

UCSC genome browser

More...UCSCi		uc009oka.2, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U06483 mRNA Translation: AAA67204.1
AK135040 mRNA Translation: BAE22394.1
AC159314 Genomic DNA No translation available.
CH466522 Genomic DNA Translation: EDL25153.1
BC113140 mRNA Translation: AAI13141.1
U89893 Genomic DNA Translation: AAC53308.1
CCDSiCCDS22891.1
PIRiI48950
RefSeqiNP_032345.2, NM_008319.2

3D structure databases

SMRiQ60625
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200503, 4 interactors
IntActiQ60625, 4 interactors
MINTiQ60625
STRINGi10090.ENSMUSP00000019616

PTM databases

CarbonylDBiQ60625
GlyConnecti2409, 15 N-Linked glycans (10 sites)
GlyGeniQ60625, 14 sites, 15 N-linked glycans (10 sites)
iPTMnetiQ60625
PhosphoSitePlusiQ60625

Proteomic databases

PaxDbiQ60625
PeptideAtlasiQ60625
PRIDEiQ60625
ProteomicsDBi267086

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		2298, 282 antibodies

The DNASU plasmid repository

More...DNASUi		15898

Genome annotation databases

EnsembliENSMUST00000019616; ENSMUSP00000019616; ENSMUSG00000032174
GeneIDi15898
KEGGimmu:15898
UCSCiuc009oka.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7087
MGIiMGI:109430, Icam5
VEuPathDBiHostDB:ENSMUSG00000032174

Phylogenomic databases

eggNOGiENOG502QS16, Eukaryota
GeneTreeiENSGT00940000162184
HOGENOMiCLU_014560_0_0_1
InParanoidiQ60625
OMAiPGIYVCN
OrthoDBi731140at2759
PhylomeDBiQ60625
TreeFamiTF333745

Enzyme and pathway databases

ReactomeiR-MMU-198933, Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
R-MMU-216083, Integrin cell surface interactions

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		15898, 0 hits in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Icam5, mouse

Protein Ontology

More...PROi		PR:Q60625
RNActiQ60625, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000032174, Expressed in dentate gyrus of hippocampal formation and 94 other tissues
GenevisibleiQ60625, MM

Family and domain databases

Gene3Di2.60.40.10, 9 hits
InterProiView protein in InterPro
IPR003988, ICAM
IPR013768, ICAM_N
IPR003987, ICAM_VCAM_N
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR003599, Ig_sub
IPR003598, Ig_sub2
PfamiView protein in Pfam
PF03921, ICAM_N, 1 hit
PRINTSiPR01473, ICAM
PR01472, ICAMVCAM1
SMARTiView protein in SMART
SM00409, IG, 6 hits
SM00408, IGc2, 4 hits
SUPFAMiSSF48726, SSF48726, 9 hits
PROSITEiView protein in PROSITE
PS50835, IG_LIKE, 4 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiICAM5_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60625
Secondary accession number(s): G5E826, Q2KHL7, Q3UY19
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 18, 2001
Last sequence update: October 3, 2012
Last modified: September 29, 2021
This is version 165 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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