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Protein

Adenosine receptor A2b

Gene

Adora2b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.

GO - Molecular functioni

  • G protein-coupled adenosine receptor activity Source: MGI
  • G protein-coupled receptor activity Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-417973 Adenosine P1 receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-5683826 Surfactant metabolism

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A2b
Gene namesi
Name:Adora2b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:99403 Adora2b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 8ExtracellularBy similarity8
Transmembranei9 – 33Helical; Name=1By similarityAdd BLAST25
Topological domaini34 – 43CytoplasmicBy similarity10
Transmembranei44 – 67Helical; Name=2By similarityAdd BLAST24
Topological domaini68 – 78ExtracellularBy similarityAdd BLAST11
Transmembranei79 – 101Helical; Name=3By similarityAdd BLAST23
Topological domaini102 – 121CytoplasmicBy similarityAdd BLAST20
Transmembranei122 – 144Helical; Name=4By similarityAdd BLAST23
Topological domaini145 – 178ExtracellularBy similarityAdd BLAST34
Transmembranei179 – 203Helical; Name=5By similarityAdd BLAST25
Topological domaini204 – 235CytoplasmicBy similarityAdd BLAST32
Transmembranei236 – 259Helical; Name=6By similarityAdd BLAST24
Topological domaini260 – 267ExtracellularBy similarity8
Transmembranei268 – 291Helical; Name=7By similarityAdd BLAST24
Topological domaini292 – 332CytoplasmicBy similarityAdd BLAST41

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2237
GuidetoPHARMACOLOGYi20

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000690041 – 332Adenosine receptor A2bAdd BLAST332

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi78 ↔ 171PROSITE-ProRule annotation
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi163N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi311S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ60614
PRIDEiQ60614

PTM databases

iPTMnetiQ60614
PhosphoSitePlusiQ60614
SwissPalmiQ60614

Expressioni

Gene expression databases

BgeeiENSMUSG00000018500 Expressed in 172 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_ADORA2B
GenevisibleiQ60614 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018644

Chemistry databases

BindingDBiQ60614

Structurei

3D structure databases

ProteinModelPortaliQ60614
SMRiQ60614
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni173 – 182Agonist bindingBy similarity10
Regioni247 – 254Agonist bindingBy similarity8
Regioni266 – 276Agonist bindingBy similarityAdd BLAST11

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiQ60614
KOiK04267
OMAiCCLVKCL
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR001435 Adeno_A2B_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00554 ADENOSINA2BR
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60614-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQLETQDALY VALELVIAAL AVAGNVLVCA AVGASSALQT PTNYFLVSLA
60 70 80 90 100
TADVAVGLFA IPFAITISLG FCTDFHGCLF LACFVLVLTQ SSIFSLLAVA
110 120 130 140 150
VDRYLAIRVP LRYKGLVTGT RARGIIAVLW VLAFGIGLTP FLGWNSKDSA
160 170 180 190 200
TSNCTELGDG IANKSCCPVT CLFENVVPMS YMVYFNFFGC VLPPLLIMLV
210 220 230 240 250
IYIKIFMVAC KQLQRMELMD HSRTTLQREI HAAKSLAMIV GIFALCWLPV
260 270 280 290 300
HAINCITLFH PALAKDKPKW VMNVAILLSH ANSVVNPIVY AYRNRDFRYS
310 320 330
FHKIISRYVL CQAETKGGSG QAGAQSTLSL GL
Length:332
Mass (Da):36,120
Last modified:July 27, 2011 - v2
Checksum:iBABE2C782001564A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti169V → L in AAA19001 (PubMed:8157966).Curated1
Sequence conflicti215R → S in AAA19001 (PubMed:8157966).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05673 mRNA Translation: AAA19001.1
AK047002 mRNA Translation: BAC32938.1
AL596110 Genomic DNA No translation available.
BC116415 mRNA Translation: AAI16416.1
BC116416 mRNA Translation: AAI16417.1
CCDSiCCDS24822.1
PIRiI48933
RefSeqiNP_031439.2, NM_007413.4
UniGeneiMm.40740

Genome annotation databases

EnsembliENSMUST00000018644; ENSMUSP00000018644; ENSMUSG00000018500
GeneIDi11541
KEGGimmu:11541
UCSCiuc007jio.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05673 mRNA Translation: AAA19001.1
AK047002 mRNA Translation: BAC32938.1
AL596110 Genomic DNA No translation available.
BC116415 mRNA Translation: AAI16416.1
BC116416 mRNA Translation: AAI16417.1
CCDSiCCDS24822.1
PIRiI48933
RefSeqiNP_031439.2, NM_007413.4
UniGeneiMm.40740

3D structure databases

ProteinModelPortaliQ60614
SMRiQ60614
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000018644

Chemistry databases

BindingDBiQ60614
ChEMBLiCHEMBL2237
GuidetoPHARMACOLOGYi20

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ60614
PhosphoSitePlusiQ60614
SwissPalmiQ60614

Proteomic databases

PaxDbiQ60614
PRIDEiQ60614

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000018644; ENSMUSP00000018644; ENSMUSG00000018500
GeneIDi11541
KEGGimmu:11541
UCSCiuc007jio.1 mouse

Organism-specific databases

CTDi136
MGIiMGI:99403 Adora2b

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiQ60614
KOiK04267
OMAiCCLVKCL
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Enzyme and pathway databases

ReactomeiR-MMU-417973 Adenosine P1 receptors
R-MMU-418555 G alpha (s) signalling events
R-MMU-5683826 Surfactant metabolism

Miscellaneous databases

PROiPR:Q60614
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018500 Expressed in 172 organ(s), highest expression level in lumbar subsegment of spinal cord
CleanExiMM_ADORA2B
GenevisibleiQ60614 MM

Family and domain databases

InterProiView protein in InterPro
IPR001435 Adeno_A2B_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00554 ADENOSINA2BR
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAA2BR_MOUSE
AccessioniPrimary (citable) accession number: Q60614
Secondary accession number(s): Q8BXI2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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