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Protein

Adenosine receptor A1

Gene

Adora1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-417973 Adenosine P1 receptors
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine receptor A1
Gene namesi
Name:Adora1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:99401 Adora1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10ExtracellularSequence analysis10
Transmembranei11 – 33Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini34 – 46CytoplasmicSequence analysisAdd BLAST13
Transmembranei47 – 69Helical; Name=2Sequence analysisAdd BLAST23
Topological domaini70 – 80ExtracellularSequence analysisAdd BLAST11
Transmembranei81 – 102Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini103 – 123CytoplasmicSequence analysisAdd BLAST21
Transmembranei124 – 146Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini147 – 176ExtracellularSequence analysisAdd BLAST30
Transmembranei177 – 201Helical; Name=5Sequence analysisAdd BLAST25
Topological domaini202 – 235CytoplasmicSequence analysisAdd BLAST34
Transmembranei236 – 259Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini260 – 267ExtracellularSequence analysis8
Transmembranei268 – 292Helical; Name=7Sequence analysisAdd BLAST25
Topological domaini293 – 326CytoplasmicSequence analysisAdd BLAST34

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3688
GuidetoPHARMACOLOGYi18

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689921 – 326Adenosine receptor A1Add BLAST326

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi80 ↔ 169PROSITE-ProRule annotation
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi159N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi309S-palmitoyl cysteineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ60612
PRIDEiQ60612

PTM databases

iPTMnetiQ60612
PhosphoSitePlusiQ60612

Expressioni

Gene expression databases

BgeeiENSMUSG00000042429
CleanExiMM_ADORA1
ExpressionAtlasiQ60612 baseline and differential
GenevisibleiQ60612 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043522

Chemistry databases

BindingDBiQ60612

Structurei

3D structure databases

ProteinModelPortaliQ60612
SMRiQ60612
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00550000074524
HOGENOMiHOG000015770
HOVERGENiHBG106962
InParanoidiQ60612
KOiK04265
OMAiVWAVRIN
OrthoDBiEOG091G0I3U
TreeFamiTF325296

Family and domain databases

InterProiView protein in InterPro
IPR001068 Adeno_A1_rcpt
IPR001634 Adenosn_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00552 ADENOSINEA1R
PR00424 ADENOSINER
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60612-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPYISAFQA AYIGIEVLIA LVSVPGNVLV IWAVKVNQAL RDATFCFIVS
60 70 80 90 100
LAVADVAVGA LVIPLAILIN IGPQTYFHTC LMVACPVLIL TQSSILALLA
110 120 130 140 150
IAVDRYLRVK IPLRYKTVVT QRRAAVAIAG CWILSLVVGL TPMFGWNNLS
160 170 180 190 200
EVEQAWIANG SVGEPVIKCE FEKVISMEYM VYFNFFVWVL PPLLLMVLIY
210 220 230 240 250
LEVFYLIRKQ LNKKVSASSG DPQKYYGKEL KIAKSLALIL FLFALSWLPL
260 270 280 290 300
HILNCITLFC PTCQKPSILI YIAIFLTHGN SAMNPIVYAF RIHKFRVTFL
310 320
KIWNDHFRCQ PKPPIEEDIP EEKADD
Length:326
Mass (Da):36,638
Last modified:July 27, 2011 - v4
Checksum:i6E5AC2D94447963C
GO

Sequence cautioni

The sequence AAA18999 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10A → G (PubMed:8157966).Curated1
Sequence conflicti107L → P in AAD31843 (PubMed:10318839).Curated1
Sequence conflicti325D → E in AAA18999 (PubMed:8157966).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05671 mRNA Translation: AAA18999.1 Different initiation.
AK043954 mRNA Translation: BAC31713.1
AK045729 mRNA Translation: BAC32474.1
AK134553 mRNA Translation: BAE22183.1
CH466520 Genomic DNA Translation: EDL39623.1
AF133099 Genomic DNA Translation: AAD31843.1
CCDSiCCDS15305.1
RefSeqiNP_001008533.1, NM_001008533.3
NP_001034599.1, NM_001039510.2
NP_001269874.1, NM_001282945.1
NP_001278857.1, NM_001291928.1
XP_006529142.1, XM_006529079.2
UniGeneiMm.298908

Genome annotation databases

EnsembliENSMUST00000038191; ENSMUSP00000043522; ENSMUSG00000042429
ENSMUST00000086465; ENSMUSP00000083656; ENSMUSG00000042429
ENSMUST00000169927; ENSMUSP00000132105; ENSMUSG00000042429
GeneIDi11539
KEGGimmu:11539
UCSCiuc007crj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiAA1R_MOUSE
AccessioniPrimary (citable) accession number: Q60612
Secondary accession number(s): Q8BGU7, Q9WUF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 27, 2011
Last modified: July 18, 2018
This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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