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Protein

Myosin light polypeptide 6

Gene

Myl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  • actin-dependent ATPase activity Source: HGNC
  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

Keywordsi

Molecular functionMotor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction
R-MMU-5627123 RHO GTPases activate PAKs

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light polypeptide 6
Alternative name(s):
17 kDa myosin light chain
Short name:
LC17
Myosin light chain 3
Short name:
MLC-3
Myosin light chain alkali 3
Short name:
Myosin light chain A3
Smooth muscle and nonmuscle myosin light chain alkali 6
Gene namesi
Name:Myl6
Synonyms:Myln
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:109318 Myl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001986912 – 151Myosin light polypeptide 6Add BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylcysteine1 Publication1
Modified residuei57PhosphoserineCombined sources1
Modified residuei81N6-acetyllysineCombined sources1
Isoform Smooth muscle (identifier: Q60605-2)
Modified residuei135PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ60605
PeptideAtlasiQ60605
PRIDEiQ60605
TopDownProteomicsiQ60605-2 [Q60605-2]

2D gel databases

REPRODUCTION-2DPAGEiQ60605
UCD-2DPAGEiQ60605

PTM databases

iPTMnetiQ60605
PhosphoSitePlusiQ60605
SwissPalmiQ60605

Expressioni

Gene expression databases

BgeeiENSMUSG00000090841 Expressed in 19 organ(s), highest expression level in lung
ExpressionAtlasiQ60605 baseline and differential
GenevisibleiQ60605 MM

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains. Interacts with SPATA6 (PubMed:25605924).1 Publication

Protein-protein interaction databases

BioGridi201658, 5 interactors
IntActiQ60605, 9 interactors
MINTiQ60605
STRINGi10090.ENSMUSP00000128803

Structurei

3D structure databases

ProteinModelPortaliQ60605
SMRiQ60605
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 42EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini84 – 119EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini119 – 151EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ60605
KOiK12751
OMAiIPTSHVG
PhylomeDBiQ60605
TreeFamiTF351553

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform Non-muscle (identifier: Q60605-1) [UniParc]FASTAAdd to basket
Also known as: MLC3nm, LC17A, LC17-nm

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCDFTEDQTA EFKEAFQLFD RTGDGKILYS QCGDVMRALG QNPTNAEVLK
60 70 80 90 100
VLGNPKSDEM NVKVLDFEHF LPMLQTVAKN KDQGTYEDYV EGLRVFDKEG
110 120 130 140 150
NGTVMGAEIR HVLVTLGEKM TEEEVEMLVA GHEDSNGCIN YEAFVRHILS

G
Length:151
Mass (Da):16,930
Last modified:January 23, 2007 - v3
Checksum:iA2B7B4F41179523D
GO
Isoform Smooth muscle (identifier: Q60605-2) [UniParc]FASTAAdd to basket
Also known as: MLC3sm, LC17B, LC17-sm

The sequence of this isoform differs from the canonical sequence as follows:
     143-151: AFVRHILSG → ELVRMVLNG

Show »
Length:151
Mass (Da):16,961
Checksum:i25B244E686095233
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P7Q9A0A1W2P7Q9_MOUSE
Myosin light polypeptide 6
Myl6
158Annotation score:
A0A1W2P6F6A0A1W2P6F6_MOUSE
Myosin light polypeptide 6
Myl6
152Annotation score:
A0A1W2P6G5A0A1W2P6G5_MOUSE
Myosin light polypeptide 6
Myl6
139Annotation score:
A0A1W2P888A0A1W2P888_MOUSE
Myosin light polypeptide 6
Myl6
38Annotation score:
A0A1W2P8F0A0A1W2P8F0_MOUSE
Myosin light polypeptide 6
Myl6
46Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54N → T in AAC52278 (PubMed:7804326).Curated1
Sequence conflicti82D → A in AAC52278 (PubMed:7804326).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009736143 – 151AFVRHILSG → ELVRMVLNG in isoform Smooth muscle. 1 Publication9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026760 mRNA Translation: AAH26760.1
U04443 mRNA Translation: AAC52278.1
CCDSiCCDS48728.1 [Q60605-2]
RefSeqiNP_001304147.1, NM_001317218.1 [Q60605-1]
NP_034990.1, NM_010860.4 [Q60605-2]
UniGeneiMm.337074

Genome annotation databases

EnsembliENSMUST00000164181; ENSMUSP00000128803; ENSMUSG00000090841 [Q60605-2]
ENSMUST00000218127; ENSMUSP00000151693; ENSMUSG00000090841 [Q60605-1]
GeneIDi17904
KEGGimmu:17904
UCSCiuc007hnb.1 mouse [Q60605-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC026760 mRNA Translation: AAH26760.1
U04443 mRNA Translation: AAC52278.1
CCDSiCCDS48728.1 [Q60605-2]
RefSeqiNP_001304147.1, NM_001317218.1 [Q60605-1]
NP_034990.1, NM_010860.4 [Q60605-2]
UniGeneiMm.337074

3D structure databases

ProteinModelPortaliQ60605
SMRiQ60605
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201658, 5 interactors
IntActiQ60605, 9 interactors
MINTiQ60605
STRINGi10090.ENSMUSP00000128803

PTM databases

iPTMnetiQ60605
PhosphoSitePlusiQ60605
SwissPalmiQ60605

2D gel databases

REPRODUCTION-2DPAGEiQ60605
UCD-2DPAGEiQ60605

Proteomic databases

PaxDbiQ60605
PeptideAtlasiQ60605
PRIDEiQ60605
TopDownProteomicsiQ60605-2 [Q60605-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000164181; ENSMUSP00000128803; ENSMUSG00000090841 [Q60605-2]
ENSMUST00000218127; ENSMUSP00000151693; ENSMUSG00000090841 [Q60605-1]
GeneIDi17904
KEGGimmu:17904
UCSCiuc007hnb.1 mouse [Q60605-1]

Organism-specific databases

CTDi4637
MGIiMGI:109318 Myl6

Phylogenomic databases

eggNOGiKOG0030 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00590000082921
HOGENOMiHOG000233018
HOVERGENiHBG012180
InParanoidiQ60605
KOiK12751
OMAiIPTSHVG
PhylomeDBiQ60605
TreeFamiTF351553

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction
R-MMU-5627123 RHO GTPases activate PAKs

Miscellaneous databases

PROiPR:Q60605
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000090841 Expressed in 19 organ(s), highest expression level in lung
ExpressionAtlasiQ60605 baseline and differential
GenevisibleiQ60605 MM

Family and domain databases

CDDicd00051 EFh, 1 hit
InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR002048 EF_hand_dom
PfamiView protein in Pfam
PF13405 EF-hand_6, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS50222 EF_HAND_2, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMYL6_MOUSE
AccessioniPrimary (citable) accession number: Q60605
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 149 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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