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Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi: 7,8-dihydroneopterin triphosphate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. GTP cyclohydrolase FolE2 (folE2), GTP cyclohydrolase 1 (folE)
This subpathway is part of the pathway 7,8-dihydroneopterin triphosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 7,8-dihydroneopterin triphosphate from GTP, the pathway 7,8-dihydroneopterin triphosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei152May be catalytically importantUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciMCAP243233:G1G0X-2289-MONOMER
UniPathwayiUPA00848; UER00151

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
Gene namesi
Name:folE2UniRule annotation
Ordered Locus Names:MCA2318
OrganismiMethylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath)
Taxonomic identifieri243233 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaMethylococcalesMethylococcaceaeMethylococcus
Proteomesi
  • UP000006821 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001477131 – 268GTP cyclohydrolase FolE2Add BLAST268

Proteomic databases

PRIDEiQ605G6

Interactioni

Protein-protein interaction databases

STRINGi243233.MCA2318

Structurei

3D structure databases

ProteinModelPortaliQ605G6
SMRiQ605G6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GTP cyclohydrolase IV family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DZA Bacteria
COG1469 LUCA
HOGENOMiHOG000280679
KOiK09007
OMAiHNQRGRG
OrthoDBiPOG091H0MIO

Family and domain databases

HAMAPiMF_01527_B GTP_cyclohydrol_B, 1 hit
InterProiView protein in InterPro
IPR022838 GTP_cyclohydrolase_FolE2
IPR003801 GTP_cyclohydrolase_FolE2/MptA
PANTHERiPTHR36445 PTHR36445, 1 hit
PfamiView protein in Pfam
PF02649 GCHY-1, 1 hit

Sequencei

Sequence statusi: Complete.

Q605G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEGLAIDD VQGRADLRRI DIDRVGIKGI RHPVRVRDRS LGEQHTVARF
60 70 80 90 100
DMAVSLPHHF KGTHMSRFVE IINGHDREID IASFEAMLAE MMQRLNAEAG
110 120 130 140 150
RIEMRFPYFL EKRAPVTGVR SLMDYEVALI GEVSVATTTT WLGVTVPVTS
160 170 180 190 200
LCPCSKAISE RGAHNQRSHV TTAVRMRDFV WIEELIEWVE AEASSPIYGL
210 220 230 240 250
LKRPDEKYVT EYAYDHPRFV EDLVRGVAAR LDTEPRIAAY AVEVENFESI
260
HNHSAYALIE RDKRTADA
Length:268
Mass (Da):30,505
Last modified:November 23, 2004 - v1
Checksum:i9F9910A81B39B0B0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017282 Genomic DNA Translation: AAU91629.1
RefSeqiWP_010961546.1, NC_002977.6

Genome annotation databases

EnsemblBacteriaiAAU91629; AAU91629; MCA2318
KEGGimca:MCA2318

Similar proteinsi

Entry informationi

Entry nameiGCH4_METCA
AccessioniPrimary (citable) accession number: Q605G6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 2005
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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