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Protein

F-box/WD repeat-containing protein 2

Gene

Fbxw2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.

GO - Molecular functioni

Keywordsi

Biological processUbl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
F-box/WD repeat-containing protein 2
Alternative name(s):
F-box and WD-40 domain-containing protein 2
Protein MD6
Gene namesi
Name:Fbxw2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1353435 Fbxw2

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000509891 – 422F-box/WD repeat-containing protein 2Add BLAST422

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei298N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ60584
PaxDbiQ60584
PRIDEiQ60584

PTM databases

iPTMnetiQ60584
PhosphoSitePlusiQ60584

Expressioni

Tissue specificityi

Widely expressed during embryogenesis and in adult tissues.1 Publication

Gene expression databases

CleanExiMM_FBXW2

Interactioni

Subunit structurei

Directly interacts with SKP1 and CUL1.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028220

Structurei

3D structure databases

ProteinModelPortaliQ60584
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini54 – 101F-boxPROSITE-ProRule annotationAdd BLAST48
Repeati146 – 183WD 1Add BLAST38
Repeati185 – 221WD 2Add BLAST37
Repeati224 – 265WD 3Add BLAST42
Repeati276 – 314WD 4Add BLAST39

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQD2 Eukaryota
ENOG410XP3H LUCA
HOVERGENiHBG051593
InParanoidiQ60584

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q60584-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERKDFETWL DNISVTFLSL TDLQKNETLD HLISLSGAVQ LRHLSNNLET
60 70 80 90 100
LLKRDFLKLL PLELSFYLLK WLDPQTLLTC CLVSKQWNKV ISACTEVWQT
110 120 130 140 150
ACKNLGWQID DSVQDSLHWK KVYLKAILRM KQLEDHEAFE TSSLIGHSAR
160 170 180 190 200
VYALYYKDGL LCTGSDDLSA KLWDVSTGQC VYGIQTHTCA AVKFDEQKLV
210 220 230 240 250
TGSFDNTVAC WEWSSGARTQ HFRGHTGAVF SVDYSDELDI LVSGSADFAV
260 270 280 290 300
KVWALSAGTC LNTLTGHTEW VTKVVLQKCK VKSLLHSPGD YILLSADKYE
310 320 330 340 350
IKIWPIGREI NCKCLKTLSV SEDRSICLQP RLHFDGKYIV CSSALGLYQW
360 370 380 390 400
DFASYDILRV IKTPEVANLA LLGFGDVFAL LFDNHYLYIM DLRTESLISR
410 420
WPLPEYRKSK RGSSFLAGER PG
Length:422
Mass (Da):47,896
Last modified:June 28, 2011 - v2
Checksum:iF3E4C8FE01309CAE
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9QUH1Q9QUH1_MOUSE
F-box protein FWD2
Fbxw2 Fwd2
454Annotation score:
A2AUF9A2AUF9_MOUSE
F-box/WD repeat-containing protein ...
Fbxw2
325Annotation score:
Q8BS25Q8BS25_MOUSE
F-box/WD repeat-containing protein ...
Fbxw2
359Annotation score:
A2AUG1A2AUG1_MOUSE
F-box/WD repeat-containing protein ...
Fbxw2
389Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21T → M in CAA38237 (PubMed:1296816).Curated1
Sequence conflicti87W → R in CAA38237 (PubMed:1296816).Curated1
Sequence conflicti413S → T in CAA38237 (PubMed:1296816).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54352 mRNA Translation: CAA38237.1
AL929106 Genomic DNA No translation available.
PIRiA56640
UniGeneiMm.4465

Genome annotation databases

UCSCiuc008jja.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X54352 mRNA Translation: CAA38237.1
AL929106 Genomic DNA No translation available.
PIRiA56640
UniGeneiMm.4465

3D structure databases

ProteinModelPortaliQ60584
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000028220

PTM databases

iPTMnetiQ60584
PhosphoSitePlusiQ60584

Proteomic databases

MaxQBiQ60584
PaxDbiQ60584
PRIDEiQ60584

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc008jja.2 mouse

Organism-specific databases

MGIiMGI:1353435 Fbxw2

Phylogenomic databases

eggNOGiENOG410IQD2 Eukaryota
ENOG410XP3H LUCA
HOVERGENiHBG051593
InParanoidiQ60584

Miscellaneous databases

ChiTaRSiFbxw2 mouse
PROiPR:Q60584
SOURCEiSearch...

Gene expression databases

CleanExiMM_FBXW2

Family and domain databases

Gene3Di2.130.10.10, 1 hit
InterProiView protein in InterPro
IPR036047 F-box-like_dom_sf
IPR001810 F-box_dom
IPR020472 G-protein_beta_WD-40_rep
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF12937 F-box-like, 1 hit
PF00400 WD40, 3 hits
PRINTSiPR00320 GPROTEINBRPT
SMARTiView protein in SMART
SM00256 FBOX, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF81383 SSF81383, 1 hit
PROSITEiView protein in PROSITE
PS50181 FBOX, 1 hit
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiFBXW2_MOUSE
AccessioniPrimary (citable) accession number: Q60584
Secondary accession number(s): E9PXP3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: June 28, 2011
Last modified: February 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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