UniProtKB - Q60575 (KIF1B_MOUSE)
Kinesin-like protein KIF1B
Kif1b
Functioni
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 97 – 104 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATPase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- ATP-dependent microtubule motor activity Source: MGI
- ATP-dependent microtubule motor activity, plus-end-directed Source: GO_Central
- kinase binding Source: MGI
- microtubule binding Source: GO_Central
- microtubule motor activity Source: UniProtKB
- scaffold protein binding Source: MGI
GO - Biological processi
- anterograde axonal transport Source: UniProtKB
- anterograde neuronal dense core vesicle transport Source: MGI
- cellular response to nerve growth factor stimulus Source: Ensembl
- cytoskeleton-dependent intracellular transport Source: UniProtKB
- embryo development ending in birth or egg hatching Source: UniProtKB
- lysosome localization Source: MGI
- microtubule-based movement Source: UniProtKB
- mitochondrion transport along microtubule Source: MGI
- neuromuscular synaptic transmission Source: UniProtKB
- neuron-neuron synaptic transmission Source: UniProtKB
- positive regulation of gene expression Source: MGI
- protein localization to cell periphery Source: MGI
- response to rotenone Source: Ensembl
- retrograde neuronal dense core vesicle transport Source: MGI
- transport along microtubule Source: MGI
- vesicle-mediated transport Source: GO_Central
Keywordsi
Molecular function | Motor protein |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189, Kinesins |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF1B |
Gene namesi | Name:Kif1b |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:108426, Kif1b |
Subcellular locationi
Cytoskeleton
Mitochondrion
- Mitochondrion By similarity
Other locations
- synaptic vesicle By similarity
Cytoskeleton
- kinesin complex Source: GO_Central
- microtubule Source: GO_Central
- microtubule associated complex Source: UniProtKB
Mitochondrion
- mitochondrion Source: MGI
Other locations
- axon Source: GO_Central
- axon cytoplasm Source: GOC
- cytoplasmic vesicle Source: UniProtKB
- cytoplasmic vesicle membrane Source: UniProtKB
- dendrite Source: GO_Central
- membrane Source: MGI
- neuron projection Source: UniProtKB
- synaptic vesicle Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell junction, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Microtubule, Mitochondrion, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000125408 | 2 – 1816 | Kinesin-like protein KIF1BAdd BLAST | 1815 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylserineBy similarity | 1 | |
Modified residuei | 647 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 652 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1054 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1057 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1416 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1454 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1487 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1573 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1603 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1610 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1613 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
jPOSTi | Q60575 |
PaxDbi | Q60575 |
PeptideAtlasi | Q60575 |
PRIDEi | Q60575 |
PTM databases
iPTMneti | Q60575 |
PhosphoSitePlusi | Q60575 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000063077, Expressed in retina and 324 other tissues |
ExpressionAtlasi | Q60575, baseline and differential |
Genevisiblei | Q60575, MM |
Interactioni
Subunit structurei
Monomer (PubMed:7528108).
Interacts with KIFBP (By similarity).
Interacts (via C-terminus end of the kinesin-motor domain) with CHP1; the interaction occurs in a calcium-dependent manner (By similarity).
By similarity1 PublicationGO - Molecular functioni
- kinase binding Source: MGI
- microtubule binding Source: GO_Central
- scaffold protein binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 200936, 8 interactors |
IntActi | Q60575, 6 interactors |
STRINGi | 10090.ENSMUSP00000061472 |
Miscellaneous databases
RNActi | Q60575, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 5 – 354 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 350 | |
Domaini | 556 – 612 | FHAPROSITE-ProRule annotationAdd BLAST | 57 | |
Domaini | 1702 – 1799 | PHPROSITE-ProRule annotationAdd BLAST | 98 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 270 – 350 | Interaction with KBPBy similarityAdd BLAST | 81 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 365 – 386 | Sequence analysisAdd BLAST | 22 | |
Coiled coili | 470 – 502 | Sequence analysisAdd BLAST | 33 | |
Coiled coili | 668 – 737 | Sequence analysisAdd BLAST | 70 | |
Coiled coili | 841 – 869 | Sequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG0245, Eukaryota |
GeneTreei | ENSGT00940000157445 |
HOGENOMi | CLU_001485_10_0_1 |
InParanoidi | Q60575 |
OMAi | LHQEDEF |
PhylomeDBi | Q60575 |
TreeFami | TF105221 |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR022164, Kinesin-like IPR027640, Kinesin-like_fam IPR022140, Kinesin-like_KIF1-typ IPR032405, Kinesin_assoc IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF12473, DUF3694, 1 hit PF00498, FHA, 1 hit PF12423, KIF1B, 1 hit PF00225, Kinesin, 1 hit PF16183, Kinesin_assoc, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00129, KISc, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit PS50003, PH_DOMAIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSGASVKVAV RVRPFNSRET SKESKCIIQM QGNSTSIINP KNPKEAPKSF
60 70 80 90 100
SFDYSYWSHT SPEDPCFASQ NRVYNDIGKE MLLHAFEGYN VCIFAYGQTG
110 120 130 140 150
AGKSYTMMGK QEESQAGIIP QLCEELFEKI NDNCNEEMSY SVEVSYMEIY
160 170 180 190 200
CERVRDLLNP KNKGNLRVRE HPLLGPYVED LSKLAVTSYT DIADLMDAGN
210 220 230 240 250
KARTVAATNM NETSSRSHAV FTIVFTQKKQ DPETNLSTEK VSKISLVDLA
260 270 280 290 300
GSERADSTGA KGTRLKEGAN INKSLTTLGK VISALAEVDN CTSKSKKKKK
310 320 330 340 350
TDFIPYRDSV LTWLLRENLG GNSRTAMVAA LSPADINYDE TLSTLRYADR
360 370 380 390 400
AKQIKCNAVI NEDPNAKLVR ELKEEVTRLK DLLRAQGLGD IIDIDPLIDD
410 420 430 440 450
YSGSGGKYLK DFQNNKHRYL LASENQRPGN FSTASMGSLT SSPSSCSLNS
460 470 480 490 500
QVGLTSVTSI QERIMSTPGG EEAIERLKES EKIIAELNET WEEKLRKTEA
510 520 530 540 550
IRMEREALLA EMGVAIREDG GTLGVFSPKK TPHLVNLNED PLMSECLLYY
560 570 580 590 600
IKDGITRVGQ ADAERRQDIV LSGAHIKEEH CLFRSERSNT GEVIVTLEPC
610 620 630 640 650
ERSETYVNGK RVAHPVQLRS GNRIIMGKNH VFRFNHPEQA RAEREKTPSA
660 670 680 690 700
ETPSEPVDWT FAQRELLEKQ GIDMKQEMEK RLQEMEILYK KEKEEADLLL
710 720 730 740 750
EQQRLDYESK LQALQRQVET RSLAAETTEE EEEEEEVPWT QHEFELAQWA
760 770 780 790 800
FRKWKSHQFT SLRDLLWGNA VYLKEANAIS VELKKKVQFQ FVLLTDTLYS
810 820 830 840 850
PVPPELLPSE MEKTHEDRPF PRTVVAVEVQ DLKNGATHYW SLDKLKQRLD
860 870 880 890 900
LMREMYDRAG EVASSAQDDS ETTMTGSDPF YDRFHWFKLV GSSPIFHGCV
910 920 930 940 950
NERLADRTPS PTFSTADSDI TELADEQQDA MEDFDDEAFV DDTGSDAGTE
960 970 980 990 1000
EGSELFSDGH DPFYDRSPWF ILVGRAFVYL SNLLYPVPLI HRVAIVSEKG
1010 1020 1030 1040 1050
EVRGFLRVAV QAIAADEEAP DYGSGIRQSG TAKISFDNEY FNQSDFSSAA
1060 1070 1080 1090 1100
MTRSGLSLEE LRIVEGQGQS SEVISPPEEV NRMNDLDLKS GTLLDGKMVM
1110 1120 1130 1140 1150
EGFSEEIGNH LKLGSAFTFR VTVLQASGIL PEYADIFCQF NFLHRHDEAF
1160 1170 1180 1190 1200
STEPLKNNGR GSPLGFYHVQ NIAVEVTESF VDYIKTKPIV FEVFGHYQQH
1210 1220 1230 1240 1250
PLHLQGQDLN SPPQPSRRFF PPPMPLSKPV PATKLNTMNK TTLGQSMSKY
1260 1270 1280 1290 1300
DLLVWFEISE LEPTGEYIPA VVDHTAGLPC QGTFLLHQGI QRRITVTIIH
1310 1320 1330 1340 1350
EKGSELHWKD VRELVVGRIR NKPEVDEAAV DAVLSLNIIS AKSLKAAHSS
1360 1370 1380 1390 1400
SRTFYRFEAV WDSSLHNSLL LNRVTPYGEK IYMTLSAYLE LDHCIQPAVI
1410 1420 1430 1440 1450
TKDVCMVFYS RDAKISPPRS LRNLFGSGYS KSPDSNRVTG IYELSLCKMA
1460 1470 1480 1490 1500
DTGSPGMQRR RRKVLDTSVA YVRGEENLAG WRPRGDSLIL EHQWELEKLE
1510 1520 1530 1540 1550
LLHEVEKTRH FLLLRERLGD SVPKSLSDSL SPSLSSGTLS TSTSISSQIS
1560 1570 1580 1590 1600
TTTFESAITP SESSGYDSAD VESLVDREKE LATKCLQLLT HTFNREFSQV
1610 1620 1630 1640 1650
HGSISDCKLS DISPIGRDPS VSSFSSSTLT PSSTCPSLVD SRSSSMDQKT
1660 1670 1680 1690 1700
PEANSRASSP CQEFEQFQIV PTVETPYLAR AGKNEFLNLV PDIEEVRAGS
1710 1720 1730 1740 1750
VVSKKGYLHF KEPLSSNWAK HFVVVRRPYV FIYNSDKDPV ERGIINLSTA
1760 1770 1780 1790 1800
QVEYSEDQQA MVKTPNTFAV CTKHRGVLLQ ALNDKDMNDW LYAFNPLLAG
1810
TIRSKLSRRC PSQPKY
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A5F8MPF0 | A0A5F8MPF0_MOUSE | Kinesin-like protein KIF1B | Kif1b | 1,883 | Annotation score: | ||
A2AH75 | A2AH75_MOUSE | Kinesin-like protein KIF1B | Kif1b | 1,150 | Annotation score: | ||
F6XNB6 | F6XNB6_MOUSE | Kinesin-like protein KIF1B | Kif1b | 495 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 117 | G → V (PubMed:7528108).Curated | 1 | |
Sequence conflicti | 117 | G → V (PubMed:10571041).Curated | 1 | |
Sequence conflicti | 520 – 523 | GGTL → RGDI in BAA04503 (PubMed:7528108).Curated | 4 | |
Sequence conflicti | 909 | P → S in BAA75243 (Ref. 4) Curated | 1 | |
Sequence conflicti | 1608 – 1609 | KL → TW in AAD39438 (PubMed:10341097).Curated | 2 | |
Sequence conflicti | 1612 | I → V in AAD39438 (PubMed:10341097).Curated | 1 | |
Sequence conflicti | 1784 | D → G in BAA75243 (Ref. 4) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_002862 | 289 – 294 | Missing in isoform 2 and isoform 3. 2 Publications | 6 | |
Alternative sequenceiVSP_002863 | 394 – 434 | IDPLI…NFSTA → T in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 41 | |
Alternative sequenceiVSP_002864 | 707 – 1196 | YESKL…EVFGH → ADSDSGDDSDKRSCEESWKL ITSLREKLPPSKLQTIVKKC GLPSSGKKREPIKMYQIPQR RRLSKDSKWVTISDLKIQAV KEICYEVALNDFRHSRQEIE ALAIVKMKELCAMYGKKDPN ERDSWRAVARDVWDTVGVGD EKIEDMMVTGKGGTDVDDLK VHIDKLEDILQEVKKQNNMK DEEIKVLRNKMLKMEKVLPL IGSQEQKSQGSHKTKEPLVA GANSVSDNGVSKGESGELGK EERVSQLMNGDPAFRRGRLR WMRQEQIRFKNLQQQEITKQ LRRQNVPHRFIPPENRKPRF PFKSNPKHRNSWSPGTHIII TEDEVIELRIPKDEEGRKEN KEESQEKVGRAASRDVQSAW GTRSQDHIQVSKQHISNQQP PPQLRWRSNSLNNGQPKTTR CQATASSESLNSHSGHPTAD LQTFQAKRHIHQHRQPYCNY NTGGQVEGSTASCCQKQTDK PSHCNQFVTPPRMRRQFSAP NLKAGRETTV in isoform 3. 1 PublicationAdd BLAST | 490 | |
Alternative sequenceiVSP_002865 | 1197 – 1816 | Missing in isoform 3. 1 PublicationAdd BLAST | 620 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D17577 mRNA Translation: BAA04503.1 AF090190 mRNA Translation: AAF06718.1 AF131865 mRNA Translation: AAD39438.1 AB023656 mRNA Translation: BAA75243.1 |
CCDSi | CCDS18956.1 [Q60575-2] CCDS18957.1 [Q60575-3] CCDS71521.1 [Q60575-1] |
PIRi | A55289 |
RefSeqi | NP_001277924.1, NM_001290995.1 [Q60575-1] NP_032467.2, NM_008441.2 |
Genome annotation databases
Ensembli | ENSMUST00000055647; ENSMUSP00000061472; ENSMUSG00000063077 [Q60575-2] ENSMUST00000060537; ENSMUSP00000056754; ENSMUSG00000063077 [Q60575-1] |
GeneIDi | 16561 |
KEGGi | mmu:16561 |
UCSCi | uc008vvy.2, mouse [Q60575-2] uc008vvz.2, mouse [Q60575-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D17577 mRNA Translation: BAA04503.1 AF090190 mRNA Translation: AAF06718.1 AF131865 mRNA Translation: AAD39438.1 AB023656 mRNA Translation: BAA75243.1 |
CCDSi | CCDS18956.1 [Q60575-2] CCDS18957.1 [Q60575-3] CCDS71521.1 [Q60575-1] |
PIRi | A55289 |
RefSeqi | NP_001277924.1, NM_001290995.1 [Q60575-1] NP_032467.2, NM_008441.2 |
3D structure databases
SMRi | Q60575 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200936, 8 interactors |
IntActi | Q60575, 6 interactors |
STRINGi | 10090.ENSMUSP00000061472 |
PTM databases
iPTMneti | Q60575 |
PhosphoSitePlusi | Q60575 |
Proteomic databases
jPOSTi | Q60575 |
PaxDbi | Q60575 |
PeptideAtlasi | Q60575 |
PRIDEi | Q60575 |
Protocols and materials databases
Antibodypediai | 4196, 104 antibodies |
DNASUi | 16561 |
Genome annotation databases
Ensembli | ENSMUST00000055647; ENSMUSP00000061472; ENSMUSG00000063077 [Q60575-2] ENSMUST00000060537; ENSMUSP00000056754; ENSMUSG00000063077 [Q60575-1] |
GeneIDi | 16561 |
KEGGi | mmu:16561 |
UCSCi | uc008vvy.2, mouse [Q60575-2] uc008vvz.2, mouse [Q60575-1] |
Organism-specific databases
CTDi | 23095 |
MGIi | MGI:108426, Kif1b |
Phylogenomic databases
eggNOGi | KOG0245, Eukaryota |
GeneTreei | ENSGT00940000157445 |
HOGENOMi | CLU_001485_10_0_1 |
InParanoidi | Q60575 |
OMAi | LHQEDEF |
PhylomeDBi | Q60575 |
TreeFami | TF105221 |
Enzyme and pathway databases
Reactomei | R-MMU-2132295, MHC class II antigen presentation R-MMU-6811434, COPI-dependent Golgi-to-ER retrograde traffic R-MMU-983189, Kinesins |
Miscellaneous databases
BioGRID-ORCSi | 16561, 2 hits in 17 CRISPR screens |
ChiTaRSi | Kif1b, mouse |
PROi | PR:Q60575 |
RNActi | Q60575, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000063077, Expressed in retina and 324 other tissues |
ExpressionAtlasi | Q60575, baseline and differential |
Genevisiblei | Q60575, MM |
Family and domain databases
CDDi | cd00060, FHA, 1 hit |
Gene3Di | 2.30.29.30, 1 hit 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR000253, FHA_dom IPR022164, Kinesin-like IPR027640, Kinesin-like_fam IPR022140, Kinesin-like_KIF1-typ IPR032405, Kinesin_assoc IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR008984, SMAD_FHA_dom_sf |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF12473, DUF3694, 1 hit PF00498, FHA, 1 hit PF12423, KIF1B, 1 hit PF00225, Kinesin, 1 hit PF16183, Kinesin_assoc, 1 hit PF00169, PH, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00240, FHA, 1 hit SM00129, KISc, 1 hit SM00233, PH, 1 hit |
SUPFAMi | SSF49879, SSF49879, 1 hit SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS50006, FHA_DOMAIN, 1 hit PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit PS50003, PH_DOMAIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF1B_MOUSE | |
Accessioni | Q60575Primary (citable) accession number: Q60575 Secondary accession number(s): Q9R0B4, Q9WVE5, Q9Z119 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | January 11, 2001 | |
Last modified: | December 2, 2020 | |
This is version 171 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families