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Protein

Corticotropin-releasing factor-binding protein

Gene

Crhbp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.

GO - Molecular functioni

  • corticotropin-releasing hormone binding Source: MGI
  • peptide binding Source: UniProtKB

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)

Names & Taxonomyi

Protein namesi
Recommended name:
Corticotropin-releasing factor-binding protein
Short name:
CRF-BP
Short name:
CRF-binding protein
Alternative name(s):
Corticotropin-releasing hormone-binding protein
Short name:
CRH-BP
Gene namesi
Name:Crhbp
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:88497 Crhbp

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24By similarityAdd BLAST24
ChainiPRO_000002099525 – 322Corticotropin-releasing factor-binding proteinAdd BLAST298

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi60 ↔ 81By similarity
Disulfide bondi104 ↔ 141By similarity
Disulfide bondi183 ↔ 205By similarity
Glycosylationi204N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi237 ↔ 264By similarity
Disulfide bondi277 ↔ 318By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ60571
PRIDEiQ60571

PTM databases

PhosphoSitePlusiQ60571

Expressioni

Gene expression databases

BgeeiENSMUSG00000021680 Expressed in 64 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_CRHBP
ExpressionAtlasiQ60571 baseline and differential
GenevisibleiQ60571 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042578

Structurei

3D structure databases

ProteinModelPortaliQ60571
SMRiQ60571
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CRF-binding protein family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II3D Eukaryota
ENOG4111JUQ LUCA
GeneTreeiENSGT00390000001362
HOGENOMiHOG000004819
HOVERGENiHBG051117
InParanoidiQ60571
OMAiTIVEITM
OrthoDBiEOG091G094Q
PhylomeDBiQ60571
TreeFamiTF105383

Family and domain databases

InterProiView protein in InterPro
IPR008435 CRF-bd
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR10278 PTHR10278, 1 hit
PfamiView protein in Pfam
PF05428 CRF-BP, 1 hit
PIRSFiPIRSF009279 CRF_bd, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q60571-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSPNFKLQCH FILILLTALR GESRYLEVQE AAVYDPLLLF SANLKRDLAE
60 70 80 90 100
EQPYRRALRC LDMLSLPGQF TFTADRPQLH CAAFFIGEPE EFITIHYDLV
110 120 130 140 150
SIDCQGGDFL KVFDGWILKG EKFPSSQDHP LPTMKRYTDF CESGLTRRSI
160 170 180 190 200
RSSQNVAMVF FRVHEPGNGF TITIKTDPNL FPCNVISQTP SGRFTLVVPY
210 220 230 240 250
QHQNCSFSII YPVAIKISDL TLGHLHGLQL KKPAAGCGGT GDFVELLGGT
260 270 280 290 300
GLDPSKMMPL ADLCYPFLGP AQMKISCDNA VVRMVSSGKH INRVTFEYRQ
310 320
LEPFELETST GNSIPEYCLS SL
Length:322
Mass (Da):36,048
Last modified:November 1, 1996 - v1
Checksum:i2F8A5D80CD54C7BC
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A217FL62A0A217FL62_MOUSE
Corticotropin-releasing factor-bind...
Crhbp
329Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33323 mRNA Translation: AAC52253.1
BC061247 mRNA Translation: AAH61247.1
CCDSiCCDS26698.1
RefSeqiNP_940800.1, NM_198408.3
UniGeneiMm.316614

Genome annotation databases

EnsembliENSMUST00000221025; ENSMUSP00000152083; ENSMUSG00000021680
GeneIDi12919
KEGGimmu:12919
UCSCiuc007rmk.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U33323 mRNA Translation: AAC52253.1
BC061247 mRNA Translation: AAH61247.1
CCDSiCCDS26698.1
RefSeqiNP_940800.1, NM_198408.3
UniGeneiMm.316614

3D structure databases

ProteinModelPortaliQ60571
SMRiQ60571
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000042578

PTM databases

PhosphoSitePlusiQ60571

Proteomic databases

PaxDbiQ60571
PRIDEiQ60571

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000221025; ENSMUSP00000152083; ENSMUSG00000021680
GeneIDi12919
KEGGimmu:12919
UCSCiuc007rmk.2 mouse

Organism-specific databases

CTDi1393
MGIiMGI:88497 Crhbp

Phylogenomic databases

eggNOGiENOG410II3D Eukaryota
ENOG4111JUQ LUCA
GeneTreeiENSGT00390000001362
HOGENOMiHOG000004819
HOVERGENiHBG051117
InParanoidiQ60571
OMAiTIVEITM
OrthoDBiEOG091G094Q
PhylomeDBiQ60571
TreeFamiTF105383

Enzyme and pathway databases

ReactomeiR-MMU-373080 Class B/2 (Secretin family receptors)

Miscellaneous databases

ChiTaRSiCrhbp mouse
PROiPR:Q60571
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000021680 Expressed in 64 organ(s), highest expression level in vestibular membrane of cochlear duct
CleanExiMM_CRHBP
ExpressionAtlasiQ60571 baseline and differential
GenevisibleiQ60571 MM

Family and domain databases

InterProiView protein in InterPro
IPR008435 CRF-bd
IPR035914 Sperma_CUB_dom_sf
PANTHERiPTHR10278 PTHR10278, 1 hit
PfamiView protein in Pfam
PF05428 CRF-BP, 1 hit
PIRSFiPIRSF009279 CRF_bd, 1 hit
SUPFAMiSSF49854 SSF49854, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCRHBP_MOUSE
AccessioniPrimary (citable) accession number: Q60571
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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