Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q60520 (SIN3A_MOUSE)

Entry version 197 (17 Jun 2020)
Sequence version 3 (05 Oct 2010)
Previous versions | rss
Help videoAdd a publicationFeedback
Protein

Paired amphipathic helix protein Sin3a

Gene

Sin3a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a transcriptional repressor. Corepressor for REST. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also interacts with MXD1-MAX heterodimers to repress transcription by tethering SIN3A to DNA. Acts cooperatively with OGT to repress transcription in parallel with histone deacetylation. Involved in the control of the circadian rhythms. Required for the transcriptional repression of circadian target genes, such as PER1, mediated by the large PER complex through histone deacetylation. Cooperates with FOXK1 to regulate cell cycle progression probably by repressing cell cycle inhibitor genes expression (PubMed:22476904). Required for cortical neuron differentiation and callosal axon elongation (PubMed:27399968).6 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRepressor
Biological processBiological rhythms, Transcription, Transcription regulation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-400206 Regulation of lipid metabolism by PPARalpha
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9022692 Regulation of MECP2 expression and activity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3a
Alternative name(s):
Histone deacetylase complex subunit Sin3a
Transcriptional corepressor Sin3a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Sin3a
Synonyms:Kiaa4126
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:107157 Sin3a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

SIN3A knockdown causes a significant decrease in the amount of cortical progenitors in the proliferative zone at the peak of neurogenesis, and results in altered neuronal identity and aberrant corticocortical projections.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi307A → V: Greatly reduced binding to MAD; when associated with D-308 and A-311. 1 Publication1
Mutagenesisi308I → D: Greatly reduced binding to MAD; when associated with V-307 and A-311. 1 Publication1
Mutagenesisi309N → D: No effect on binding to MAD. 1 Publication1
Mutagenesisi311V → A: Greatly reduced binding to MAD; when associated with V-307 and D-308. 1 Publication1
Mutagenesisi326K → A: No effect on binding to MAD. 1 Publication1
Mutagenesisi329L → A: Greatly reduced binding to MAD; when associated with A-332. 1 Publication1
Mutagenesisi332L → A: Greatly reduced binding to MAD; when associated with A-329. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001215381 – 1274Paired amphipathic helix protein Sin3aAdd BLAST1274

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei10PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki122Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei277PhosphoserineCombined sources1
Modified residuei284PhosphothreonineCombined sources1
Modified residuei470N6-acetyllysineBy similarity1
Cross-linki564Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei833PhosphoserineCombined sources1
Modified residuei861PhosphoserineBy similarity1
Modified residuei866N6-acetyllysineCombined sources1
Modified residuei876N6-acetyllysineCombined sources1
Modified residuei941PhosphoserineBy similarity1
Modified residuei1090PhosphoserineBy similarity1
Modified residuei1113PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

SUMO1 sumoylated by TOPORS. Probably desumoylated by SENP2.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q60520

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q60520

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q60520

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q60520

PeptideAtlas

More...PeptideAtlasi		Q60520

PRoteomics IDEntifications database

More...PRIDEi		Q60520

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q60520

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q60520

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Highest levels in testis, lung and thymus. Expressed at relatively high levels throughout brain development. In adult mice, expression is high in neurogenic regions such as the subventricular zone, rostral migratory stream, olfactory bulb and dentate gyrus (PubMed:27399968).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000042557 Expressed in secondary oocyte and 287 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q60520 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q60520 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS (PubMed:8649810).

Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity).

Interacts with BAZ2A, MXD1, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3 (PubMed:7889570, PubMed:8521822, PubMed:9139820, PubMed:9702189, PubMed:10734093, PubMed:10950960, PubMed:11106735, PubMed:11882901, PubMed:11909966, PubMed:12130660, PubMed:12198165, PubMed:12398767, PubMed:16805913, PubMed:19144721).

Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30 (PubMed:11390640).

Interacts with TET1; the interaction recruits SIN3A to gene promoters (PubMed:21490601). The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A (PubMed:21680841).

Interacts with KLF11 (PubMed:15774581).

Interacts with PPHLN1 (By similarity).

Found in a complex with YY1, GON4L and HDAC1 (PubMed:21454521).

Interacts (via PAH2) with FOXK1 (PubMed:22476904, PubMed:25402684).

Interacts with FOXK2 (PubMed:25402684).

Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (PubMed:28554894).

Interacts with SINHCAF (PubMed:28554894).

Interacts with SPHK2 (By similarity).

By similarity23 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		203256, 74 interactors

ComplexPortal: manually curated resource of macromolecular complexes

More...ComplexPortali		CPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443 SIN3A histone deacetylase complex

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		Q60520

Database of interacting proteins

More...DIPi		DIP-469N

Protein interaction database and analysis system

More...IntActi		Q60520, 37 interactors

Molecular INTeraction database

More...MINTi		Q60520

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000130221

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q60520 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11274
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q60520

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		Q60520

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini119 – 189PAH 1PROSITE-ProRule annotationAdd BLAST71
Domaini300 – 383PAH 2PROSITE-ProRule annotationAdd BLAST84
Domaini457 – 526PAH 3PROSITE-ProRule annotationAdd BLAST70

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni119 – 196Interaction with HCFC1By similarityAdd BLAST78
Regioni205 – 479Interaction with REST1 PublicationAdd BLAST275
Regioni459 – 526Interaction with SAP301 PublicationAdd BLAST68
Regioni524 – 851Interaction with NCOR1Add BLAST328
Regioni525 – 660Interactions with SUDS3 and SAP130By similarityAdd BLAST136
Regioni688 – 830Interactions with HDAC1 and ARID4BBy similarityAdd BLAST143
Regioni889 – 968Interaction with OGTBy similarityAdd BLAST80

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili904 – 933Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi207 – 265Gln-richAdd BLAST59
Compositional biasi218 – 285Pro-richAdd BLAST68
Compositional biasi836 – 842Poly-Glu7

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG4204 Eukaryota
COG5602 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155491

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_001360_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q60520

KEGG Orthology (KO)

More...KOi		K11644

Identification of Orthologs from Complete Genome Data

More...OMAi		GRDELCN

Database of Orthologous Groups

More...OrthoDBi		253485at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q60520

TreeFam database of animal gene trees

More...TreeFami		TF106187

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.1160.11, 3 hits

Intrinsically Disordered proteins with Extensive Annotations and Literature

More...IDEALi		IID50089

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
IPR037969 SIN3A

The PANTHER Classification System

More...PANTHERi		PTHR12346 PTHR12346, 1 hit
PTHR12346:SF2 PTHR12346:SF2, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00761 HDAC_interact, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47762 SSF47762, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51477 PAH, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q60520-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKRRLDDQES PVYAAQQRRI PGSTEAFSHQ HRVLAPAPPV YEAVSETMQS 
        60         70         80         90        100
ATGIQYSVAP NYQVSAVPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ 
       110        120        130        140        150
SHAHPAPPVA PVQGQQQFQR LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI 
       160        170        180        190        200
MKEFKSQSID TPGVISRVSQ LFKGHPDLIM GFNTFLPPGY KIEVQTNDMV 
       210        220        230        240        250
NVTTPGQVHQ IPTHGIQPQP QPPPQHPSQP SSQSAPTPAQ PAPQPTAAKV 
       260        270        280        290        300
SKPSQLQAHT PASQQTPPLP PYASPRSPPV QPHTPVTISL GTAPSLQNNQ 
       310        320        330        340        350
PVEFNHAINY VNKIKNRFQG QPDIYKAFLE ILHTYQKEQR NAKEAGGNYT 
       360        370        380        390        400
PALTEQEVYA QVARLFKNQE DLLSEFGQFL PDANSSVLLS KTTAEKVDSV 
       410        420        430        440        450
RNDHGGTVKK PQLNNKPQRP SQNGCQIRRH SGTGATPPVK KKPKLMSLKE 
       460        470        480        490        500
SSMADASKHG VGTESLFFDK VRKALRSAEA YENFLRCLVI FNQEVISRAE 
       510        520        530        540        550
LVQLVSPFLG KFPELFNWFK NFLGYKESVH LESFPKERAT EGIAMEIDYA 
       560        570        580        590        600
SCKRLGSSYR ALPKSYQQPK CTGRTPLCKE VLNDTWVSFP SWSEDSTFVS 
       610        620        630        640        650
SKKTQYEEHI YRCEDERFEL DVVLETNLAT IRVLEAIQKK LSRLSAEEQA 
       660        670        680        690        700
KFRLDNTLGG TSEVIHRKAL QRIYADKAAD IIDGLRKNPS IAVPIVLKRL 
       710        720        730        740        750
KMKEEEWREA QRGFNKVWRE QNEKYYLKSL DHQGINFKQN DTKVLRSKSL 
       760        770        780        790        800
LNEIESIYDE RQEQATEENA GVPVGPHLSL AYEDKQILED AAALIIHHVK 
       810        820        830        840        850
RQTGIQKEDK YKIKQIMHHF IPDLLFAQRG DLSDVEEEEE EEMDVDEATG 
       860        870        880        890        900
APKKHNGVGG SPPKSKLLFS NTAAQKLRGM DEVYNLFYVN NNWYIFMRLH 
       910        920        930        940        950
QILCLRLLRI CSQAERQIEE ENREREWERE VLGIKRDKSD SPAIQLRLKE 
       960        970        980        990       1000
PMDVDVEDYY PAFLDMVRSL LDGNIDSSQY EDSLREMFTI HAYIAFTMDK 
      1010       1020       1030       1040       1050
LIQSIVRQLQ HIVSDEVCVQ VTDLYLAENN NGATGGQLNS QTSRSLLESA 
      1060       1070       1080       1090       1100
YQRKAEQLMS DENCFKLMFI QSQGQVQLTV ELLDTEEENS DDPVEAERWS 
      1110       1120       1130       1140       1150
DYVERYMSSD TTSPELREHL AQKPVFLPRN LRRIRKCQRG REQQEKEGKE 
      1160       1170       1180       1190       1200
GNSKKTMENV ESLDKLECRF KLNSYKMVYV IKSEDYMYRR TALLRAHQSH 
      1210       1220       1230       1240       1250
ERVSKRLHQR FQAWVDKWTK EHVPREMAAE TSKWLMGEGL EGLVPCTTTC 
      1260       1270 
DTETLHFVSI NKYRVKYGTV FKAP
Length:1,274
Mass (Da):145,088
Last modified:October 5, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i80FE378F62ED7CB3
GO
Isoform 2 (identifier: Q60520-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1097-1097: E → EVWT

Show »
Length:1,277
Mass (Da):145,474
Checksum:iF578FED21F4824D3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PXF9E9PXF9_MOUSE
Paired amphipathic helix protein Si...
Sin3a
133Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9Q2L1E9Q2L1_MOUSE
Paired amphipathic helix protein Si...
Sin3a
102Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB01610 differs from that shown. The cDNA contains an internal 15bp tandem duplication.Curated
The sequence AAH52716 differs from that shown. Probable cloning artifact leading to an internal deletion.Curated
The sequence AAH53385 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence BAD90217 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti144Y → H in AAB01610 (PubMed:7601471).Curated1
Sequence conflicti154F → L in AAH53385 (PubMed:15489334).Curated1
Sequence conflicti303E → H in AAB01610 (PubMed:7601471).Curated1
Sequence conflicti514E → G in AAH53385 (PubMed:15489334).Curated1
Sequence conflicti720 – 721EQ → DE in AAB01610 (PubMed:7601471).Curated2
Sequence conflicti827A → D in AAA89119 (PubMed:8649810).Curated1
Sequence conflicti899L → R in AAH52716 (PubMed:15489334).Curated1
Sequence conflicti912S → F in AAH52716 (PubMed:15489334).Curated1
Sequence conflicti969S → Q in AAB01610 (PubMed:7601471).Curated1
Sequence conflicti1047L → V in AAB01610 (PubMed:7601471).Curated1
Sequence conflicti1205 – 1207KRL → QGK in AAA69773 (PubMed:7889570).Curated3
Sequence conflicti1205K → KK in AAA69772 (PubMed:7889570).Curated1
Sequence conflicti1215 – 1216VD → GK in AAA69772 (PubMed:7889570).Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0399181097E → EVWT in isoform 2. 3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L36831 mRNA Translation: AAB01610.1 Sequence problems.
U22394 mRNA Translation: AAA89119.1
AK220292 mRNA Translation: BAD90217.1 Different initiation.
BC052716 mRNA Translation: AAH52716.1 Sequence problems.
BC053385 mRNA Translation: AAH53385.1 Sequence problems.
L38620 mRNA Translation: AAA69773.2
L38621 mRNA Translation: AAA69772.2

The Consensus CDS (CCDS) project

More...CCDSi		CCDS23216.1 [Q60520-2]
CCDS52805.1 [Q60520-1]

Protein sequence database of the Protein Information Resource

More...PIRi		A56068
I61713

NCBI Reference Sequences

More...RefSeqi		NP_001103820.1, NM_001110350.1 [Q60520-1]
NP_001103821.1, NM_001110351.1 [Q60520-2]
NP_035508.2, NM_011378.2 [Q60520-2]
XP_006510953.1, XM_006510890.3 [Q60520-1]
XP_006510954.1, XM_006510891.3 [Q60520-1]
XP_006510955.1, XM_006510892.3 [Q60520-1]
XP_006510956.1, XM_006510893.3 [Q60520-1]
XP_011240985.1, XM_011242683.2 [Q60520-1]
XP_011240986.1, XM_011242684.2 [Q60520-1]
XP_011240987.1, XM_011242685.2 [Q60520-1]
XP_011240988.1, XM_011242686.2 [Q60520-1]
XP_017168720.1, XM_017313231.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000049169; ENSMUSP00000045044; ENSMUSG00000042557 [Q60520-2]
ENSMUST00000167715; ENSMUSP00000130641; ENSMUSG00000042557 [Q60520-2]
ENSMUST00000168177; ENSMUSP00000130221; ENSMUSG00000042557 [Q60520-1]
ENSMUST00000168502; ENSMUSP00000128956; ENSMUSG00000042557 [Q60520-1]
ENSMUST00000168678; ENSMUSP00000126601; ENSMUSG00000042557 [Q60520-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		20466

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:20466

UCSC genome browser

More...UCSCi		uc009ptx.2 mouse [Q60520-1]
uc012gtw.1 mouse [Q60520-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36831 mRNA Translation: AAB01610.1 Sequence problems.
U22394 mRNA Translation: AAA89119.1
AK220292 mRNA Translation: BAD90217.1 Different initiation.
BC052716 mRNA Translation: AAH52716.1 Sequence problems.
BC053385 mRNA Translation: AAH53385.1 Sequence problems.
L38620 mRNA Translation: AAA69773.2
L38621 mRNA Translation: AAA69772.2
CCDSiCCDS23216.1 [Q60520-2]
CCDS52805.1 [Q60520-1]
PIRiA56068
I61713
RefSeqiNP_001103820.1, NM_001110350.1 [Q60520-1]
NP_001103821.1, NM_001110351.1 [Q60520-2]
NP_035508.2, NM_011378.2 [Q60520-2]
XP_006510953.1, XM_006510890.3 [Q60520-1]
XP_006510954.1, XM_006510891.3 [Q60520-1]
XP_006510955.1, XM_006510892.3 [Q60520-1]
XP_006510956.1, XM_006510893.3 [Q60520-1]
XP_011240985.1, XM_011242683.2 [Q60520-1]
XP_011240986.1, XM_011242684.2 [Q60520-1]
XP_011240987.1, XM_011242685.2 [Q60520-1]
XP_011240988.1, XM_011242686.2 [Q60520-1]
XP_017168720.1, XM_017313231.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G1ENMR-B295-383[»]
1S5QNMR-B295-383[»]
1S5RNMR-B295-383[»]
2L9SNMR-B295-385[»]
2LD7NMR-B456-528[»]
2N2HNMR-B608-729[»]
2RMRNMR-A119-189[»]
2RMSNMR-A119-189[»]
SMRiQ60520
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi203256, 74 interactors
ComplexPortaliCPX-3441 SIN3A histone deacetylase complex, ES cell-specific variant
CPX-3443 SIN3A histone deacetylase complex
CORUMiQ60520
DIPiDIP-469N
IntActiQ60520, 37 interactors
MINTiQ60520
STRINGi10090.ENSMUSP00000130221

PTM databases

iPTMnetiQ60520
PhosphoSitePlusiQ60520

Proteomic databases

EPDiQ60520
jPOSTiQ60520
MaxQBiQ60520
PaxDbiQ60520
PeptideAtlasiQ60520
PRIDEiQ60520

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3857 242 antibodies

Genome annotation databases

EnsembliENSMUST00000049169; ENSMUSP00000045044; ENSMUSG00000042557 [Q60520-2]
ENSMUST00000167715; ENSMUSP00000130641; ENSMUSG00000042557 [Q60520-2]
ENSMUST00000168177; ENSMUSP00000130221; ENSMUSG00000042557 [Q60520-1]
ENSMUST00000168502; ENSMUSP00000128956; ENSMUSG00000042557 [Q60520-1]
ENSMUST00000168678; ENSMUSP00000126601; ENSMUSG00000042557 [Q60520-2]
GeneIDi20466
KEGGimmu:20466
UCSCiuc009ptx.2 mouse [Q60520-1]
uc012gtw.1 mouse [Q60520-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		25942
MGIiMGI:107157 Sin3a

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
GeneTreeiENSGT00940000155491
HOGENOMiCLU_001360_0_1_1
InParanoidiQ60520
KOiK11644
OMAiGRDELCN
OrthoDBi253485at2759
PhylomeDBiQ60520
TreeFamiTF106187

Enzyme and pathway databases

ReactomeiR-MMU-3899300 SUMOylation of transcription cofactors
R-MMU-400206 Regulation of lipid metabolism by PPARalpha
R-MMU-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
R-MMU-9022692 Regulation of MECP2 expression and activity

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		20466 8 hits in 13 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Sin3a mouse
EvolutionaryTraceiQ60520

Protein Ontology

More...PROi		PR:Q60520
RNActiQ60520 protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000042557 Expressed in secondary oocyte and 287 other tissues
ExpressionAtlasiQ60520 baseline and differential
GenevisibleiQ60520 MM

Family and domain databases

Gene3Di1.20.1160.11, 3 hits
IDEALiIID50089
InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR039774 Sin3-like
IPR031693 Sin3_C
IPR037969 SIN3A
PANTHERiPTHR12346 PTHR12346, 1 hit
PTHR12346:SF2 PTHR12346:SF2, 1 hit
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIN3A_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60520
Secondary accession number(s): Q570Z7
, Q60820, Q62139, Q62140, Q7TPU8, Q7TSZ2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 5, 2010
Last modified: June 17, 2020
This is version 197 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again