UniProtKB - Q60520 (SIN3A_MOUSE)
Paired amphipathic helix protein Sin3a
Sin3a
Functioni
GO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- protein-containing complex binding Source: MGI
- RNA binding Source: MGI
- RNA polymerase II activating transcription factor binding Source: MGI
- RNA polymerase II repressing transcription factor binding Source: MGI
- transcription coactivator activity Source: MGI
- transcription corepressor activity Source: UniProtKB
- transcription factor binding Source: MGI
- transcription regulator inhibitor activity Source: MGI
GO - Biological processi
- activation of innate immune response Source: MGI
- aging Source: MGI
- cellular protein localization Source: MGI
- cellular response to dopamine Source: Ensembl
- cellular response to glucose stimulus Source: MGI
- cerebral cortex neuron differentiation Source: UniProtKB
- DNA replication Source: MGI
- hematopoietic progenitor cell differentiation Source: MGI
- histone deacetylation Source: GO_Central
- in utero embryonic development Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of circadian rhythm Source: UniProtKB
- negative regulation of histone H3-K27 acetylation Source: MGI
- negative regulation of protein localization to nucleus Source: MGI
- negative regulation of transcription, DNA-templated Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: MGI
- negative regulation of transcription regulatory region DNA binding Source: MGI
- positive regulation of chromatin silencing Source: MGI
- positive regulation of defense response to virus by host Source: MGI
- positive regulation of G2/M transition of mitotic cell cycle Source: MGI
- positive regulation of neuron differentiation Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein deacetylation Source: MGI
- regulation of axon extension Source: UniProtKB
- regulation of hormone levels Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription from RNA polymerase II promoter in response to oxidative stress Source: MGI
- response to methylglyoxal Source: MGI
- response to organonitrogen compound Source: MGI
- rhythmic process Source: UniProtKB-KW
Keywordsi
Molecular function | Repressor |
Biological process | Biological rhythms, Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-3899300, SUMOylation of transcription cofactors R-MMU-400206, Regulation of lipid metabolism by PPARalpha R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-9022692, Regulation of MECP2 expression and activity |
Names & Taxonomyi
Protein namesi | Recommended name: Paired amphipathic helix protein Sin3aAlternative name(s): Histone deacetylase complex subunit Sin3a Transcriptional corepressor Sin3a |
Gene namesi | Name:Sin3a Synonyms:Kiaa4126 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:107157, Sin3a |
Subcellular locationi
Nucleus
- histone deacetylase complex Source: GO_Central
- nucleolus Source: UniProtKB-SubCell
- nucleoplasm Source: MGI
- nucleus Source: UniProtKB
- Sin3 complex Source: MGI
Other locations
- chromatin Source: MGI
- kinetochore Source: MGI
- protein-containing complex Source: MGI
- transcription regulator complex Source: MGI
- transcription repressor complex Source: UniProtKB
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 307 | A → V: Greatly reduced binding to MAD; when associated with D-308 and A-311. 1 Publication | 1 | |
Mutagenesisi | 308 | I → D: Greatly reduced binding to MAD; when associated with V-307 and A-311. 1 Publication | 1 | |
Mutagenesisi | 309 | N → D: No effect on binding to MAD. 1 Publication | 1 | |
Mutagenesisi | 311 | V → A: Greatly reduced binding to MAD; when associated with V-307 and D-308. 1 Publication | 1 | |
Mutagenesisi | 326 | K → A: No effect on binding to MAD. 1 Publication | 1 | |
Mutagenesisi | 329 | L → A: Greatly reduced binding to MAD; when associated with A-332. 1 Publication | 1 | |
Mutagenesisi | 332 | L → A: Greatly reduced binding to MAD; when associated with A-329. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000121538 | 1 – 1274 | Paired amphipathic helix protein Sin3aAdd BLAST | 1274 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 10 | PhosphoserineBy similarity | 1 | |
Cross-linki | 122 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 134 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 277 | PhosphoserineCombined sources | 1 | |
Modified residuei | 284 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 470 | N6-acetyllysineBy similarity | 1 | |
Cross-linki | 564 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 833 | PhosphoserineCombined sources | 1 | |
Modified residuei | 861 | PhosphoserineBy similarity | 1 | |
Modified residuei | 866 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 876 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 941 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1090 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1113 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q60520 |
jPOSTi | Q60520 |
MaxQBi | Q60520 |
PaxDbi | Q60520 |
PeptideAtlasi | Q60520 |
PRIDEi | Q60520 |
ProteomicsDBi | 261047 [Q60520-2] 261048 [Q60520-1] |
PTM databases
iPTMneti | Q60520 |
PhosphoSitePlusi | Q60520 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000042557, Expressed in secondary oocyte and 303 other tissues |
ExpressionAtlasi | Q60520, baseline and differential |
Genevisiblei | Q60520, MM |
Interactioni
Subunit structurei
Interacts with ARID4B, BRMS1L, HCFC1, HDAC1, HDAC2, MXI1, SAP30L, SAP130, SFPQ and TOPORS (PubMed:8649810).
Interacts with OGT (via TPRs 1-6); the interaction mediates transcriptional repression in parallel with histone deacetylase (By similarity).
Interacts with BAZ2A, MXD1, MXD3, MXD4, MBD2, DACH1, NCOR1, NR4A2, REST, RLIM, SAP30, SETDB1, SMYD2, and SUDS3 (PubMed:7889570, PubMed:8521822, PubMed:9139820, PubMed:9702189, PubMed:10734093, PubMed:10950960, PubMed:11106735, PubMed:11882901, PubMed:11909966, PubMed:12130660, PubMed:12198165, PubMed:12398767, PubMed:16805913, PubMed:19144721).
Interacts with PHF12 in a complex composed of HDAC1, PHF12 and SAP30 (PubMed:11390640).
Interacts with TET1; the interaction recruits SIN3A to gene promoters (PubMed:21490601). The large PER complex involved in the histone deacetylation is composed of at least HDAC1, PER2, SFPQ and SIN3A (PubMed:21680841).
Interacts with KLF11 (PubMed:15774581).
Interacts with PPHLN1 (By similarity).
Found in a complex with YY1, GON4L and HDAC1 (PubMed:21454521).
Interacts (via PAH2) with FOXK1 (PubMed:22476904, PubMed:25402684).
Interacts with FOXK2 (PubMed:25402684).
Found in a complex composed of at least SINHCAF, SIN3A, HDAC1, SAP30, RBBP4, OGT and TET1 (PubMed:28554894).
Interacts with SINHCAF (PubMed:28554894).
Interacts with SPHK2 (By similarity).
By similarity23 PublicationsBinary interactionsi
Hide detailsQ60520
GO - Molecular functioni
- RNA polymerase II activating transcription factor binding Source: MGI
- RNA polymerase II repressing transcription factor binding Source: MGI
- transcription factor binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 203256, 94 interactors |
ComplexPortali | CPX-3441, SIN3A histone deacetylase complex, ES cell-specific variant CPX-3443, SIN3A histone deacetylase complex |
CORUMi | Q60520 |
DIPi | DIP-469N |
IntActi | Q60520, 37 interactors |
MINTi | Q60520 |
STRINGi | 10090.ENSMUSP00000130221 |
Miscellaneous databases
RNActi | Q60520, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | Q60520 |
SMRi | Q60520 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | Q60520 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 119 – 189 | PAH 1PROSITE-ProRule annotationAdd BLAST | 71 | |
Domaini | 300 – 383 | PAH 2PROSITE-ProRule annotationAdd BLAST | 84 | |
Domaini | 457 – 526 | PAH 3PROSITE-ProRule annotationAdd BLAST | 70 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 119 – 196 | Interaction with HCFC1By similarityAdd BLAST | 78 | |
Regioni | 205 – 479 | Interaction with REST1 PublicationAdd BLAST | 275 | |
Regioni | 459 – 526 | Interaction with SAP301 PublicationAdd BLAST | 68 | |
Regioni | 524 – 851 | Interaction with NCOR1Add BLAST | 328 | |
Regioni | 525 – 660 | Interactions with SUDS3 and SAP130By similarityAdd BLAST | 136 | |
Regioni | 688 – 830 | Interactions with HDAC1 and ARID4BBy similarityAdd BLAST | 143 | |
Regioni | 889 – 968 | Interaction with OGTBy similarityAdd BLAST | 80 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 904 – 933 | Sequence analysisAdd BLAST | 30 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 207 – 265 | Gln-richAdd BLAST | 59 | |
Compositional biasi | 218 – 285 | Pro-richAdd BLAST | 68 | |
Compositional biasi | 836 – 842 | Poly-Glu | 7 |
Keywords - Domaini
Coiled coil, RepeatPhylogenomic databases
eggNOGi | KOG4204, Eukaryota |
GeneTreei | ENSGT00940000155491 |
HOGENOMi | CLU_001360_0_1_1 |
InParanoidi | Q60520 |
OMAi | GRDELCN |
OrthoDBi | 253485at2759 |
PhylomeDBi | Q60520 |
TreeFami | TF106187 |
Family and domain databases
Gene3Di | 1.20.1160.11, 3 hits |
IDEALi | IID50089 |
InterProi | View protein in InterPro IPR013194, HDAC_interact_dom IPR003822, PAH IPR036600, PAH_sf IPR039774, Sin3-like IPR031693, Sin3_C IPR037969, SIN3A |
PANTHERi | PTHR12346, PTHR12346, 1 hit PTHR12346:SF2, PTHR12346:SF2, 1 hit |
Pfami | View protein in Pfam PF02671, PAH, 3 hits PF08295, Sin3_corepress, 1 hit PF16879, Sin3a_C, 1 hit |
SMARTi | View protein in SMART SM00761, HDAC_interact, 1 hit |
SUPFAMi | SSF47762, SSF47762, 3 hits |
PROSITEi | View protein in PROSITE PS51477, PAH, 3 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MKRRLDDQES PVYAAQQRRI PGSTEAFSHQ HRVLAPAPPV YEAVSETMQS
60 70 80 90 100
ATGIQYSVAP NYQVSAVPQS SGSHGPAIAA VHSSHHHPTA VQPHGGQVVQ
110 120 130 140 150
SHAHPAPPVA PVQGQQQFQR LKVEDALSYL DQVKLQFGSQ PQVYNDFLDI
160 170 180 190 200
MKEFKSQSID TPGVISRVSQ LFKGHPDLIM GFNTFLPPGY KIEVQTNDMV
210 220 230 240 250
NVTTPGQVHQ IPTHGIQPQP QPPPQHPSQP SSQSAPTPAQ PAPQPTAAKV
260 270 280 290 300
SKPSQLQAHT PASQQTPPLP PYASPRSPPV QPHTPVTISL GTAPSLQNNQ
310 320 330 340 350
PVEFNHAINY VNKIKNRFQG QPDIYKAFLE ILHTYQKEQR NAKEAGGNYT
360 370 380 390 400
PALTEQEVYA QVARLFKNQE DLLSEFGQFL PDANSSVLLS KTTAEKVDSV
410 420 430 440 450
RNDHGGTVKK PQLNNKPQRP SQNGCQIRRH SGTGATPPVK KKPKLMSLKE
460 470 480 490 500
SSMADASKHG VGTESLFFDK VRKALRSAEA YENFLRCLVI FNQEVISRAE
510 520 530 540 550
LVQLVSPFLG KFPELFNWFK NFLGYKESVH LESFPKERAT EGIAMEIDYA
560 570 580 590 600
SCKRLGSSYR ALPKSYQQPK CTGRTPLCKE VLNDTWVSFP SWSEDSTFVS
610 620 630 640 650
SKKTQYEEHI YRCEDERFEL DVVLETNLAT IRVLEAIQKK LSRLSAEEQA
660 670 680 690 700
KFRLDNTLGG TSEVIHRKAL QRIYADKAAD IIDGLRKNPS IAVPIVLKRL
710 720 730 740 750
KMKEEEWREA QRGFNKVWRE QNEKYYLKSL DHQGINFKQN DTKVLRSKSL
760 770 780 790 800
LNEIESIYDE RQEQATEENA GVPVGPHLSL AYEDKQILED AAALIIHHVK
810 820 830 840 850
RQTGIQKEDK YKIKQIMHHF IPDLLFAQRG DLSDVEEEEE EEMDVDEATG
860 870 880 890 900
APKKHNGVGG SPPKSKLLFS NTAAQKLRGM DEVYNLFYVN NNWYIFMRLH
910 920 930 940 950
QILCLRLLRI CSQAERQIEE ENREREWERE VLGIKRDKSD SPAIQLRLKE
960 970 980 990 1000
PMDVDVEDYY PAFLDMVRSL LDGNIDSSQY EDSLREMFTI HAYIAFTMDK
1010 1020 1030 1040 1050
LIQSIVRQLQ HIVSDEVCVQ VTDLYLAENN NGATGGQLNS QTSRSLLESA
1060 1070 1080 1090 1100
YQRKAEQLMS DENCFKLMFI QSQGQVQLTV ELLDTEEENS DDPVEAERWS
1110 1120 1130 1140 1150
DYVERYMSSD TTSPELREHL AQKPVFLPRN LRRIRKCQRG REQQEKEGKE
1160 1170 1180 1190 1200
GNSKKTMENV ESLDKLECRF KLNSYKMVYV IKSEDYMYRR TALLRAHQSH
1210 1220 1230 1240 1250
ERVSKRLHQR FQAWVDKWTK EHVPREMAAE TSKWLMGEGL EGLVPCTTTC
1260 1270
DTETLHFVSI NKYRVKYGTV FKAP
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PXF9 | E9PXF9_MOUSE | Paired amphipathic helix protein Si... | Sin3a | 133 | Annotation score: | ||
E9Q2L1 | E9Q2L1_MOUSE | Paired amphipathic helix protein Si... | Sin3a | 102 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 144 | Y → H in AAB01610 (PubMed:7601471).Curated | 1 | |
Sequence conflicti | 154 | F → L in AAH53385 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 303 | E → H in AAB01610 (PubMed:7601471).Curated | 1 | |
Sequence conflicti | 514 | E → G in AAH53385 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 720 – 721 | EQ → DE in AAB01610 (PubMed:7601471).Curated | 2 | |
Sequence conflicti | 827 | A → D in AAA89119 (PubMed:8649810).Curated | 1 | |
Sequence conflicti | 899 | L → R in AAH52716 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 912 | S → F in AAH52716 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 969 | S → Q in AAB01610 (PubMed:7601471).Curated | 1 | |
Sequence conflicti | 1047 | L → V in AAB01610 (PubMed:7601471).Curated | 1 | |
Sequence conflicti | 1205 – 1207 | KRL → QGK in AAA69773 (PubMed:7889570).Curated | 3 | |
Sequence conflicti | 1205 | K → KK in AAA69772 (PubMed:7889570).Curated | 1 | |
Sequence conflicti | 1215 – 1216 | VD → GK in AAA69772 (PubMed:7889570).Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_039918 | 1097 | E → EVWT in isoform 2. 3 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36831 mRNA Translation: AAB01610.1 Sequence problems. U22394 mRNA Translation: AAA89119.1 AK220292 mRNA Translation: BAD90217.1 Different initiation. BC052716 mRNA Translation: AAH52716.1 Sequence problems. BC053385 mRNA Translation: AAH53385.1 Sequence problems. L38620 mRNA Translation: AAA69773.2 L38621 mRNA Translation: AAA69772.2 |
CCDSi | CCDS23216.1 [Q60520-2] CCDS52805.1 [Q60520-1] |
PIRi | A56068 I61713 |
RefSeqi | NP_001103820.1, NM_001110350.1 [Q60520-1] NP_001103821.1, NM_001110351.1 [Q60520-2] NP_035508.2, NM_011378.2 [Q60520-2] XP_006510953.1, XM_006510890.3 [Q60520-1] XP_006510954.1, XM_006510891.3 [Q60520-1] XP_006510955.1, XM_006510892.3 [Q60520-1] XP_006510956.1, XM_006510893.3 [Q60520-1] XP_011240985.1, XM_011242683.2 [Q60520-1] XP_011240986.1, XM_011242684.2 [Q60520-1] XP_011240987.1, XM_011242685.2 [Q60520-1] XP_011240988.1, XM_011242686.2 [Q60520-1] XP_017168720.1, XM_017313231.1 |
Genome annotation databases
Ensembli | ENSMUST00000049169; ENSMUSP00000045044; ENSMUSG00000042557 [Q60520-2] ENSMUST00000167715; ENSMUSP00000130641; ENSMUSG00000042557 [Q60520-2] ENSMUST00000168177; ENSMUSP00000130221; ENSMUSG00000042557 [Q60520-1] ENSMUST00000168502; ENSMUSP00000128956; ENSMUSG00000042557 [Q60520-1] ENSMUST00000168678; ENSMUSP00000126601; ENSMUSG00000042557 [Q60520-2] |
GeneIDi | 20466 |
KEGGi | mmu:20466 |
UCSCi | uc009ptx.2, mouse [Q60520-1] uc012gtw.1, mouse [Q60520-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36831 mRNA Translation: AAB01610.1 Sequence problems. U22394 mRNA Translation: AAA89119.1 AK220292 mRNA Translation: BAD90217.1 Different initiation. BC052716 mRNA Translation: AAH52716.1 Sequence problems. BC053385 mRNA Translation: AAH53385.1 Sequence problems. L38620 mRNA Translation: AAA69773.2 L38621 mRNA Translation: AAA69772.2 |
CCDSi | CCDS23216.1 [Q60520-2] CCDS52805.1 [Q60520-1] |
PIRi | A56068 I61713 |
RefSeqi | NP_001103820.1, NM_001110350.1 [Q60520-1] NP_001103821.1, NM_001110351.1 [Q60520-2] NP_035508.2, NM_011378.2 [Q60520-2] XP_006510953.1, XM_006510890.3 [Q60520-1] XP_006510954.1, XM_006510891.3 [Q60520-1] XP_006510955.1, XM_006510892.3 [Q60520-1] XP_006510956.1, XM_006510893.3 [Q60520-1] XP_011240985.1, XM_011242683.2 [Q60520-1] XP_011240986.1, XM_011242684.2 [Q60520-1] XP_011240987.1, XM_011242685.2 [Q60520-1] XP_011240988.1, XM_011242686.2 [Q60520-1] XP_017168720.1, XM_017313231.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1G1E | NMR | - | B | 295-383 | [»] | |
1S5Q | NMR | - | B | 295-383 | [»] | |
1S5R | NMR | - | B | 295-383 | [»] | |
2L9S | NMR | - | B | 295-385 | [»] | |
2LD7 | NMR | - | B | 456-528 | [»] | |
2N2H | NMR | - | B | 608-729 | [»] | |
2RMR | NMR | - | A | 119-189 | [»] | |
2RMS | NMR | - | A | 119-189 | [»] | |
BMRBi | Q60520 | |||||
SMRi | Q60520 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 203256, 94 interactors |
ComplexPortali | CPX-3441, SIN3A histone deacetylase complex, ES cell-specific variant CPX-3443, SIN3A histone deacetylase complex |
CORUMi | Q60520 |
DIPi | DIP-469N |
IntActi | Q60520, 37 interactors |
MINTi | Q60520 |
STRINGi | 10090.ENSMUSP00000130221 |
PTM databases
iPTMneti | Q60520 |
PhosphoSitePlusi | Q60520 |
Proteomic databases
EPDi | Q60520 |
jPOSTi | Q60520 |
MaxQBi | Q60520 |
PaxDbi | Q60520 |
PeptideAtlasi | Q60520 |
PRIDEi | Q60520 |
ProteomicsDBi | 261047 [Q60520-2] 261048 [Q60520-1] |
Protocols and materials databases
Antibodypediai | 3857, 251 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000049169; ENSMUSP00000045044; ENSMUSG00000042557 [Q60520-2] ENSMUST00000167715; ENSMUSP00000130641; ENSMUSG00000042557 [Q60520-2] ENSMUST00000168177; ENSMUSP00000130221; ENSMUSG00000042557 [Q60520-1] ENSMUST00000168502; ENSMUSP00000128956; ENSMUSG00000042557 [Q60520-1] ENSMUST00000168678; ENSMUSP00000126601; ENSMUSG00000042557 [Q60520-2] |
GeneIDi | 20466 |
KEGGi | mmu:20466 |
UCSCi | uc009ptx.2, mouse [Q60520-1] uc012gtw.1, mouse [Q60520-2] |
Organism-specific databases
CTDi | 25942 |
MGIi | MGI:107157, Sin3a |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG4204, Eukaryota |
GeneTreei | ENSGT00940000155491 |
HOGENOMi | CLU_001360_0_1_1 |
InParanoidi | Q60520 |
OMAi | GRDELCN |
OrthoDBi | 253485at2759 |
PhylomeDBi | Q60520 |
TreeFami | TF106187 |
Enzyme and pathway databases
Reactomei | R-MMU-3899300, SUMOylation of transcription cofactors R-MMU-400206, Regulation of lipid metabolism by PPARalpha R-MMU-8936459, RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function R-MMU-9022692, Regulation of MECP2 expression and activity |
Miscellaneous databases
BioGRID-ORCSi | 20466, 19 hits in 55 CRISPR screens |
ChiTaRSi | Sin3a, mouse |
EvolutionaryTracei | Q60520 |
PROi | PR:Q60520 |
RNActi | Q60520, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000042557, Expressed in secondary oocyte and 303 other tissues |
ExpressionAtlasi | Q60520, baseline and differential |
Genevisiblei | Q60520, MM |
Family and domain databases
Gene3Di | 1.20.1160.11, 3 hits |
IDEALi | IID50089 |
InterProi | View protein in InterPro IPR013194, HDAC_interact_dom IPR003822, PAH IPR036600, PAH_sf IPR039774, Sin3-like IPR031693, Sin3_C IPR037969, SIN3A |
PANTHERi | PTHR12346, PTHR12346, 1 hit PTHR12346:SF2, PTHR12346:SF2, 1 hit |
Pfami | View protein in Pfam PF02671, PAH, 3 hits PF08295, Sin3_corepress, 1 hit PF16879, Sin3a_C, 1 hit |
SMARTi | View protein in SMART SM00761, HDAC_interact, 1 hit |
SUPFAMi | SSF47762, SSF47762, 3 hits |
PROSITEi | View protein in PROSITE PS51477, PAH, 3 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SIN3A_MOUSE | |
Accessioni | Q60520Primary (citable) accession number: Q60520 Secondary accession number(s): Q570Z7 Q7TSZ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2003 |
Last sequence update: | October 5, 2010 | |
Last modified: | April 7, 2021 | |
This is version 202 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references