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Protein

Sigma non-opioid intracellular receptor 1

Gene

SIGMAR1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration (By similarity). Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity).By similarity

Miscellaneous

Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei126Important for ligand bindingBy similarity1
Sitei172Important for ligand bindingBy similarity1

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processLipid transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Sigma non-opioid intracellular receptor 1
Alternative name(s):
Sigma 1-type opioid receptor
Short name:
Sigma1-receptor
Short name:
Sigma1R
Sterol isomerase-like protein
Gene namesi
Name:SIGMAR1
Synonyms:OPRS1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 9LumenalBy similarity9
Transmembranei10 – 30HelicalBy similarityAdd BLAST21
Topological domaini31 – 223CytoplasmicBy similarityAdd BLAST193

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasmic vesicle, Endoplasmic reticulum, Lipid droplet, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi99S → A: Alters pentazocine and NE-100-binding. No effect on pentazocine-binding and same effect on NE-100-binding; when associated with 105-AA-106. 1 Publication1
Mutagenesisi103Y → F: Alters pentazocine and NE-100-binding. 1 Publication1
Mutagenesisi105 – 106LL → AA: Alters pentazocine and NE-100-binding. No effect on pentazocine-binding and same effect on NE-100-binding; when associated with A-99. 1 Publication2

Chemistry databases

ChEMBLiCHEMBL4153

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002686511 – 223Sigma non-opioid intracellular receptor 1Add BLAST223

Expressioni

Tissue specificityi

Ubiquitously expressed with higher expression in liver, kidney and steroid-producing tissues such as placenta, ovary and adrenal gland.1 Publication

Interactioni

Subunit structurei

Homotrimer. Forms a ternary complex with ANK2 and ITPR3. The complex is disrupted by agonists. Interacts with KCNA4. Interacts with KCNA2; cocaine consumption leads to increased interaction. Interacts with RNF112 in an oxidative stress-regulated manner.By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000019032

Chemistry databases

BindingDBiQ60492

Structurei

3D structure databases

SMRiQ60492
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni2 – 8Targeting to endoplasmic reticulum-associated lipid dropletsBy similarity7
Regioni99 – 106Important for ligand-binding1 Publication8
Regioni177 – 223C-terminal hydrophobic regionCuratedAdd BLAST47

Domaini

The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.By similarity

Sequence similaritiesi

Belongs to the ERG2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4143 Eukaryota
ENOG410XP0Z LUCA
HOVERGENiHBG058220
InParanoidiQ60492

Family and domain databases

InterProiView protein in InterPro
IPR006716 ERG2_sigma1_rcpt-like
PANTHERiPTHR10868 PTHR10868, 1 hit
PfamiView protein in Pfam
PF04622 ERG2_Sigma1R, 1 hit

Sequencei

Sequence statusi: Complete.

Q60492-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQWAVGRRWL WVALFLAAVA VLTQIVWLWL GTQNFVFQRE EIAQLARQYA
60 70 80 90 100
GLDHELAFSK LIVELRRLHP VHVLPDEELQ WVFVNAGGWM GAMCLLHASL
110 120 130 140 150
SEYVLLFGTA LGSPRHSGRY WAEISDTIIS GTFHQWREGT TKSEVFYPGE
160 170 180 190 200
TVVHGPGEAT AVEWGPNTWM VEYGRGVIPS TLGFALADTV FSTQDFLTLF
210 220
YTLRVYARAL QLELTTYLFG QDP
Length:223
Mass (Da):25,311
Last modified:November 1, 1996 - v1
Checksum:i4115E51096D548F8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z66537 mRNA Translation: CAA91441.1
RefSeqiNP_001166463.1, NM_001172992.1

Genome annotation databases

GeneIDi100135589

Similar proteinsi

Entry informationi

Entry nameiSGMR1_CAVPO
AccessioniPrimary (citable) accession number: Q60492
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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