UniProtKB - Q60487 (FGF2_CAVPO)
Fibroblast growth factor 2
FGF2
Functioni
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 51 | HeparinBy similarity | 1 | |
Sitei | 143 | Important for interaction with integrinBy similarity | 1 | |
Sitei | 144 | Important for interaction with integrinBy similarity | 1 | |
Sitei | 149 | Important for interaction with integrinBy similarity | 1 |
GO - Molecular functioni
- fibroblast growth factor receptor binding Source: InterPro
- growth factor activity Source: UniProtKB-KW
- heparin binding Source: UniProtKB-KW
- integrin binding Source: UniProtKB
GO - Biological processi
- angiogenesis Source: UniProtKB-KW
- branching involved in ureteric bud morphogenesis Source: UniProtKB
- cell differentiation Source: UniProtKB-KW
- fibroblast growth factor receptor signaling pathway Source: InterPro
- negative regulation of cell death Source: UniProtKB
- positive regulation of angiogenesis Source: UniProtKB
- positive regulation of blood vessel endothelial cell migration Source: UniProtKB
- positive regulation of cell division Source: UniProtKB-KW
- positive regulation of cell migration involved in sprouting angiogenesis Source: UniProtKB
- positive regulation of sprouting angiogenesis Source: UniProtKB
Keywordsi
Molecular function | Developmental protein, Growth factor, Heparin-binding, Mitogen |
Biological process | Angiogenesis, Differentiation |
Names & Taxonomyi
Protein namesi | Recommended name: Fibroblast growth factor 2Short name: FGF-2 Alternative name(s): Basic fibroblast growth factor Short name: bFGF Heparin-binding growth factor 2 Short name: HBGF-2 Prostatic growth factor |
Gene namesi | Name:FGF2 |
Organismi | Cavia porcellus (Guinea pig) |
Taxonomic identifieri | 10141 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricomorpha › Caviidae › Cavia |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Nucleus
- Nucleus By similarity
Note: Exported from cells by an endoplasmic reticulum (ER)/Golgi-independent mechanism. Unconventional secretion of FGF2 occurs by direct translocation across the plasma membrane (By similarity). Binding of exogenous FGF2 to FGFR facilitates endocytosis followed by translocation of FGF2 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as CEP57 (By similarity).By similarity
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
Nucleus, SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000008930 | ‹1 – 170 | Fibroblast growth factor 2Add BLAST | ›170 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 4 | Omega-N-methylarginine; alternate1 Publication | 1 | |
Modified residuei | 4 | Symmetric dimethylarginine; alternate1 Publication | 1 | |
Modified residuei | 6 | Omega-N-methylarginine; alternate1 Publication | 1 | |
Modified residuei | 6 | Symmetric dimethylarginine; alternate1 Publication | 1 | |
Modified residuei | 8 | Omega-N-methylarginine; alternate1 Publication | 1 | |
Modified residuei | 8 | Symmetric dimethylarginine; alternate1 Publication | 1 | |
Modified residuei | 97 | Phosphotyrosine; by TECBy similarity | 1 | |
Cross-linki | 110 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1)By similarity |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugationProteomic databases
PRIDEi | Q60487 |
PTM databases
iPTMneti | Q60487 |
Interactioni
Subunit structurei
Monomer. Homodimer.
Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.
Interacts with CSPG4, FGFBP1 and TEC.
Found in a complex with FGFBP1, FGF1 and FGF2.
Interacts with FGFBP3.
Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling.
Interacts with SNORC (via the extracellular domain).
Interacts with glypican GPC3.
By similarityGO - Molecular functioni
- fibroblast growth factor receptor binding Source: InterPro
- growth factor activity Source: UniProtKB-KW
- integrin binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000004847 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 143 – 159 | Heparin-bindingBy similarityAdd BLAST | 17 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3885 Eukaryota ENOG4111IPH LUCA |
InParanoidi | Q60487 |
Family and domain databases
CDDi | cd00058 FGF, 1 hit |
InterProi | View protein in InterPro IPR028223 FGF2 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF |
PANTHERi | PTHR11486 PTHR11486, 1 hit PTHR11486:SF83 PTHR11486:SF83, 1 hit |
Pfami | View protein in Pfam PF00167 FGF, 1 hit |
PRINTSi | PR00263 HBGFFGF |
SMARTi | View protein in SMART SM00442 FGF, 1 hit |
SUPFAMi | SSF50353 SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247 HBGF_FGF, 1 hit |
s (2)i Sequence
Sequence statusi: Fragments.
This entry describes 2 produced by isoformsialternative initiation. AlignAdd to basketThis isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
VGGRGRGRGT AAAARREPGG AMAAGSITTL PALPEGGDGG AFAPGHFKDP
60 70 80 90 100
NGGFFLRIHP DGRVDGVREK TDPHIKLQLQ AEDRGVVSIK GVCANRYLAM
110 120 130 140 150
KEDGRLLASK CVTDECFFFE RLESNNYNTY RSRKYSSWYV ALKRTGQYKL
160 170
GSKTGPGQKA ILFLPMSAKS
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 | ||
Non-adjacent residuesi | 15 – 16 | Curated | 2 | |
Non-adjacent residuesi | 50 – 51 | Curated | 2 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018726 | ‹1 – 21 | Missing in isoform 2. CuratedAdd BLAST | ›21 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L75974 mRNA Translation: AAA85394.1 Frameshift. |
Keywords - Coding sequence diversityi
Alternative initiationSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L75974 mRNA Translation: AAA85394.1 Frameshift. |
3D structure databases
SMRi | Q60487 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10141.ENSCPOP00000004847 |
PTM databases
iPTMneti | Q60487 |
Proteomic databases
PRIDEi | Q60487 |
Phylogenomic databases
eggNOGi | KOG3885 Eukaryota ENOG4111IPH LUCA |
InParanoidi | Q60487 |
Family and domain databases
CDDi | cd00058 FGF, 1 hit |
InterProi | View protein in InterPro IPR028223 FGF2 IPR002209 Fibroblast_GF_fam IPR008996 IL1/FGF |
PANTHERi | PTHR11486 PTHR11486, 1 hit PTHR11486:SF83 PTHR11486:SF83, 1 hit |
Pfami | View protein in Pfam PF00167 FGF, 1 hit |
PRINTSi | PR00263 HBGFFGF |
SMARTi | View protein in SMART SM00442 FGF, 1 hit |
SUPFAMi | SSF50353 SSF50353, 1 hit |
PROSITEi | View protein in PROSITE PS00247 HBGF_FGF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FGF2_CAVPO | |
Accessioni | Q60487Primary (citable) accession number: Q60487 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | May 1, 2000 | |
Last modified: | October 16, 2019 | |
This is version 115 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families