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Entry version 102 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Alpha-macroglobulin

Gene
N/A
Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitorARBA annotation

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.004

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha-macroglobulinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiCavia porcellus (Guinea pig)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10141 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

SecretedARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500426562628 – 1476Sequence analysisAdd BLAST1449

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini459 – 604A2M_N_2InterPro annotationAdd BLAST146
Domaini740 – 830A2MInterPro annotationAdd BLAST91
Domaini1378 – 1465A2M_recepInterPro annotationAdd BLAST88

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. [View classification]ARBA annotation

Keywords - Domaini

Bait regionARBA annotation, SignalSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

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OMAi
CFGEESQ

Database of Orthologous Groups

More...
OrthoDBi
354230at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd02897, A2M_2, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR008930, Terpenoid_cyclase/PrenylTrfase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF07678, TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF81296, SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q60486-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGNKKLLHPN PVLLLLILLA ADASISGKPQ YMVLVPSLLH SGTPEKICLL
60 70 80 90 100
LTQLNETVTV KASLDTIREN GSLFMNMVAE KDLFQCVAFT VPQSPYPEAV
110 120 130 140 150
MFLTVEVEGP THGFRSRKTV LVKSKDSLVF VQTDKPIYKP GQTVKARVVS
160 170 180 190 200
LDENFRPLNE LFPLIFIQDP KGNRVMQWQN LKLERGLTQL SFPLSSEPLL
210 220 230 240 250
GSYSVVVHKE SGGRMHHSFT VEEFVLPKFE VQVSMPKKIT ILEQEFTVSV
260 270 280 290 300
CGRYTYGKPV PGNITMSICR NYNNPSACLS EESRAFCKKY NQQLNSQGCF
310 320 330 340 350
IQQVKTNDFQ LRRKEYEMRL RVEAKIREEG TGVQLTGTGF SEITATITKL
360 370 380 390 400
SFVKVDSYVR PGVPFFGQVR LVDGKNVPMP HKMITITASE ANYHSNATTD
410 420 430 440 450
ENGLVQFSIN TTNMIGTSLN IQVKHKDSTN CYDYQWLLEA NEGASHTANA
460 470 480 490 500
VFSLSRSFVH LEPQLGKLPC HQTQTFKAHY ILKGQELKEL VFYYVIMAKG
510 520 530 540 550
GIVQSGTYVL SVEQGNTKGH FSVSVPVESD LAPVARVLIY AILPSGEIIA
560 570 580 590 600
DSAKYNVENC LDNKVNLSFS EGQSLPASKT HLRVTASPQS LCALRAVDQS
610 620 630 640 650
VLLRKPEAVL SASSVYALLP VKDLTGFPGL LGQQEENDGE CVSLYNTYID
660 670 680 690 700
GILYSPEPNI NEKDMYGFLK DMGLKVFTNT KIQKPQLCAH VQKFEVPTMA
710 720 730 740 750
YSYSESSSFR SGPRRVPAVG IAATYSEPPK ETVRTYSPET WIWDLKVTDS
760 770 780 790 800
SGVAEVEVTV PDTITEWKAG AFCLSNDTGL GLSPTASLRA FQPFFVELTM
810 820 830 840 850
PYSVIRGEAF TLKATVLNYL PDCIRISVHL EASPKFLAEP KAKEQESYCV
860 870 880 890 900
CGNERQTVSW VVTPKSLGNV NFTVSAEALE SSELCGNEKT VVPTYGKKDT
910 920 930 940 950
IIKPLLVEPE GIEKEETWTS LIRVSDTTVS EKLHLELPSN VIQDSARATV
960 970 980 990 1000
SILGDILGSA MQNIQNLLQM PYGCGEQNMV LFAPNIYVLD YLNETQQLTP
1010 1020 1030 1040 1050
DIKSKAISYL STGYQRQLNY KHRDGSYSTF GENYRGGQGN TWLTAFVLKT
1060 1070 1080 1090 1100
FSQARKYIFI DEAHITQALS WLSQKQKDNG CFWSSGSLLN NAIKGGVEDE
1110 1120 1130 1140 1150
ISLSAYITIA LLEMSLPDTH PVVRNALFCL ESAWKSAKEG THGSHVYTKA
1160 1170 1180 1190 1200
LLAYAFALAG NQERKKEILK SLEDEGVKED NSLHWARPQK PKVSEGFLFK
1210 1220 1230 1240 1250
SQAPSAEVEM TSYVLLAYLT ARPAPTPEDL TSATDIVNWV TKQQNSHGGY
1260 1270 1280 1290 1300
SSTQDTVVAL HALSKYAAAT FTRTEKAAQV TIKSSGTFST NFEVNHNNRL
1310 1320 1330 1340 1350
LLQQVSLPTV SDSYTITVTG EGNVYLQTSL KYNVPSEKGT FPFALEAETV
1360 1370 1380 1390 1400
PQACDGPKAH TSFQISLNVS YIGSRPVSNM AIVDVKMVSG FIPLKPTVKN
1410 1420 1430 1440 1450
LEKSEHISRT EVSNNHVLIY LDKVSNQTLS LSFFVVQDIE VRDLKPAIIK
1460 1470
VYDYYETNEF AIAEYHAPCS KDPGNA
Length:1,476
Mass (Da):163,615
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0550693A068DC5C5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D84338 mRNA Translation: BAA12316.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5143

NCBI Reference Sequences

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RefSeqi
NP_001166523.1, NM_001173052.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100192394

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84338 mRNA Translation: BAA12316.1
PIRiJC5143
RefSeqiNP_001166523.1, NM_001173052.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiI39.004

Genome annotation databases

GeneIDi100192394

Phylogenomic databases

OMAiCFGEESQ
OrthoDBi354230at2759

Family and domain databases

CDDicd02897, A2M_2, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR041813, A2M_TED
IPR011626, Alpha-macroglobulin_TED
IPR013783, Ig-like_fold
IPR014756, Ig_E-set
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR008930, Terpenoid_cyclase/PrenylTrfase
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF07678, TED_complement, 1 hit
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SUPFAMiSSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF81296, SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ60486_CAVPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q60486
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 102 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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