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Protein

Potassium voltage-gated channel subfamily E member 1

Gene

KCNE1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Ancillary protein that assembles as a beta subunit with a voltage-gated potassium channel complex of pore-forming alpha subunits. Modulates the gating kinetics and enhances stability of the channel complex. Assembled with KCNB1 modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. Assembled with KCNQ1/KVLQT1 is proposed to form the slowly activating delayed rectifier cardiac potassium (IKs) channel. The outward current reaches its steady state only after 50 seconds. Assembled with KCNH2/HERG may modulate the rapidly activating component of the delayed rectifying potassium current in heart (IKr) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel, Potassium channel, Voltage-gated channel
Biological processIon transport, Potassium transport, Transport
LigandPotassium

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium voltage-gated channel subfamily E member 1
Alternative name(s):
Delayed rectifier potassium channel subunit IsK
IKs producing slow voltage-gated potassium channel subunit beta Mink
Minimal potassium channel
Gene namesi
Name:KCNE1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei44 – 66HelicalSequence analysisAdd BLAST23
Topological domaini67 – 125CytoplasmicSequence analysisAdd BLAST59

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5241

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001442761 – 125Potassium voltage-gated channel subfamily E member 1Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi26N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Phosphorylation inhibits the potassium current.By similarity
N-glycosylation at Asn-26 occurs post-translationally, and requires prior cotranslational glycosylation at Asn-5.By similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Expressioni

Gene expression databases

BgeeiENSCPOG00000011222

Interactioni

Subunit structurei

Interacts with KCNB1. Interacts with KCNC2 (By similarity). Associates with KCNH2/HERG. Interacts with KCNQ1; targets the complex KCNQ1-KCNE1 to the membrane raft (By similarity).By similarity

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000010090

Structurei

3D structure databases

SMRiQ60409
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the potassium channel KCNE family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IY71 Eukaryota
ENOG410Y1SF LUCA
GeneTreeiENSGT00510000048994
HOGENOMiHOG000113207
HOVERGENiHBG052226
InParanoidiQ60409
OMAiALYILMV
OrthoDBiEOG091G0UDJ
TreeFamiTF335976

Family and domain databases

InterProiView protein in InterPro
IPR000369 K_chnl_KCNE
IPR005424 K_chnl_volt-dep_bsu_KCNE1
PANTHERiPTHR15282 PTHR15282, 1 hit
PfamiView protein in Pfam
PF02060 ISK_Channel, 1 hit
PRINTSiPR01604 KCNE1CHANNEL
PR00168 KCNECHANNEL

Sequencei

Sequence statusi: Complete.

Q60409-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MILPNSTAVM PFLTTVWQGT VQPSSNASGL ARRSPLRDDG KLEALYILMV
60 70 80 90 100
LGFFGFFTLG IMLSYIRSKK LEHSHDPFNV YIESDTWQEK DKAFFQARVL
110 120
ENCRSCCVIE NQLTVEQPNT YLPEL
Length:125
Mass (Da):14,266
Last modified:November 1, 1996 - v1
Checksum:iE5CB6843D9AB5E76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15 – 17TVW → SVM no nucleotide entry (PubMed:8265583).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20462 mRNA Translation: AAA72394.1
PIRiA49392
I48146
RefSeqiNP_001166443.1, NM_001172972.1

Genome annotation databases

EnsembliENSCPOT00000038529; ENSCPOP00000023836; ENSCPOG00000037389
GeneIDi100135562

Similar proteinsi

Entry informationi

Entry nameiKCNE1_CAVPO
AccessioniPrimary (citable) accession number: Q60409
Secondary accession number(s): Q9QVZ5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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