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Protein

Protein translocase subunit SecY

Gene

secY

Organism
Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei75Pore ring1
Sitei79Pore ring1
Sitei174Pore ring1
Sitei179Pore ring1
Sitei260Pore ring1
Sitei406Pore ring1

GO - Molecular functioni

  • protein transmembrane transporter activity Source: GO_Central
  • signal sequence binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-512-MONOMER

Protein family/group databases

TCDBi3.A.5.7.4 the general secretory pathway (sec) family

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecY
Alternative name(s):
Protein transport protein SEC61 subunit alpha homolog
Gene namesi
Name:secY
Ordered Locus Names:MJ0478
OrganismiMethanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii)
Taxonomic identifieri243232 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomada groupMethanococciMethanococcalesMethanocaldococcaceaeMethanocaldococcus
Proteomesi
  • UP000000805 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28CytoplasmicAdd BLAST28
Transmembranei29 – 46Helical; Name=Helix 1Add BLAST18
Topological domaini47 – 55Extracellular9
Transmembranei56 – 88Discontinuously helical; Name=Helix 2Add BLAST33
Intramembranei56 – 63Helical; Name=Helix 2A8
Intramembranei64 – 696
Intramembranei70 – 88Helical; Name=Helix 2BAdd BLAST19
Topological domaini89 – 110CytoplasmicAdd BLAST22
Transmembranei111 – 129Helical; Name=Helix 3Add BLAST19
Topological domaini130 – 140ExtracellularAdd BLAST11
Transmembranei141 – 161Helical; Name=Helix 4Add BLAST21
Topological domaini162 – 168Cytoplasmic7
Transmembranei169 – 191Helical; Name=Helix 5Add BLAST23
Topological domaini192 – 209ExtracellularAdd BLAST18
Transmembranei210 – 227Helical; Name=Helix 6Add BLAST18
Topological domaini228 – 255CytoplasmicAdd BLAST28
Transmembranei256 – 277Helical; Name=Helix 7Add BLAST22
Topological domaini278 – 312ExtracellularAdd BLAST35
Transmembranei313 – 331Helical; Name=Helix 8Add BLAST19
Topological domaini332 – 382CytoplasmicAdd BLAST51
Transmembranei383 – 397Helical; Name=Helix 9Add BLAST15
Topological domaini398Extracellular1
Transmembranei399 – 412Helical; Name=Helix 10Add BLAST14
Topological domaini413 – 436CytoplasmicAdd BLAST24

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001317641 – 436Protein translocase subunit SecYAdd BLAST436

Interactioni

Subunit structurei

Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.1 Publication

Protein-protein interaction databases

STRINGi243232.MJ_0478

Structurei

Secondary structure

1436
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ60175
SMRiQ60175
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ60175

Family & Domainsi

Sequence similaritiesi

Belongs to the SecY/SEC61-alpha family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiarCOG04169 Archaea
COG0201 LUCA
InParanoidiQ60175
KOiK03076
OMAiKWGIGSG
OrthoDBiPOG093Z05PS
PhylomeDBiQ60175

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q60175-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKKLIPILEK IPEVELPVKE ITFKEKLKWT GIVLVLYFIM GCIDVYTAGA
60 70 80 90 100
QIPAIFEFWQ TITASRIGTL ITLGIGPIVT AGIIMQLLVG SGIIQMDLSI
110 120 130 140 150
PENRALFQGC QKLLSIIMCF VEAVLFVGAG AFGILTPLLA FLVIIQIAFG
160 170 180 190 200
SIILIYLDEI VSKYGIGSGI GLFIAAGVSQ TIFVGALGPE GYLWKFLNSL
210 220 230 240 250
IQGVPNIEYI APIIGTIIVF LMVVYAECMR VEIPLAHGRI KGAVGKYPIK
260 270 280 290 300
FVYVSNIPVI LAAALFANIQ LWGLALYRMG IPILGHYEGG RAVDGIAYYL
310 320 330 340 350
STPYGLSSVI SDPIHAIVYM IAMIITCVMF GIFWVETTGL DPKSMAKRIG
360 370 380 390 400
SLGMAIKGFR KSEKAIEHRL KRYIPPLTVM SSAFVGFLAT IANFIGALGG
410 420 430
GTGVLLTVSI VYRMYEQLLR EKVSELHPAI AKLLNK
Length:436
Mass (Da):47,444
Last modified:December 15, 1998 - v2
Checksum:i3E67747A7B5BDC0A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98469.1
RefSeqiWP_010869979.1, NC_000909.1

Genome annotation databases

EnsemblBacteriaiAAB98469; AAB98469; MJ_0478
GeneIDi1451340
KEGGimja:MJ_0478

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L77117 Genomic DNA Translation: AAB98469.1
RefSeqiWP_010869979.1, NC_000909.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1RH5X-ray3.20A1-436[»]
1RHZX-ray3.50A1-436[»]
2YXQX-ray3.50A1-436[»]
2YXRX-ray3.60A1-436[»]
3BO0electron microscopy9.60A2-433[»]
3BO1electron microscopy9.60A2-433[»]
3DKNelectron microscopy8.70A2-433[»]
4V4Nelectron microscopy9.00AX1-436[»]
4V7Ielectron microscopy-A2-433[»]
ProteinModelPortaliQ60175
SMRiQ60175
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243232.MJ_0478

Protein family/group databases

TCDBi3.A.5.7.4 the general secretory pathway (sec) family

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAB98469; AAB98469; MJ_0478
GeneIDi1451340
KEGGimja:MJ_0478

Phylogenomic databases

eggNOGiarCOG04169 Archaea
COG0201 LUCA
InParanoidiQ60175
KOiK03076
OMAiKWGIGSG
OrthoDBiPOG093Z05PS
PhylomeDBiQ60175

Enzyme and pathway databases

BioCyciMJAN243232:G1GKE-512-MONOMER

Miscellaneous databases

EvolutionaryTraceiQ60175

Family and domain databases

Gene3Di1.10.3370.10, 1 hit
HAMAPiMF_01465 SecY, 1 hit
InterProiView protein in InterPro
IPR026593 SecY
IPR002208 SecY/SEC61-alpha
IPR030659 SecY_CS
IPR023201 SecY_dom_sf
PANTHERiPTHR10906 PTHR10906, 1 hit
PfamiView protein in Pfam
PF00344 SecY, 1 hit
PIRSFiPIRSF004557 SecY, 1 hit
SUPFAMiSSF103491 SSF103491, 1 hit
TIGRFAMsiTIGR00967 3a0501s007, 1 hit
PROSITEiView protein in PROSITE
PS00755 SECY_1, 1 hit
PS00756 SECY_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSECY_METJA
AccessioniPrimary (citable) accession number: Q60175
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: December 15, 1998
Last modified: November 7, 2018
This is version 123 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Methanococcus jannaschii
    Methanococcus jannaschii: entries and gene names
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Main funding by: National Institutes of Health

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