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Entry version 80 (08 May 2019)
Sequence version 1 (23 Nov 2004)
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Protein
Submitted name:

LepB

Gene

lepB

Organism
Legionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
LepBImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:lepBImported
Ordered Locus Names:lpg2490Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLegionella pneumophila subsp. pneumophila (strain Philadelphia 1 / ATCC 33152 / DSM 7513)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri272624 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesLegionellaceaeLegionella
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000609 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1234 – 1256HelicalSequence analysisAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5ZSM7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q5ZSM7, 1 interactor

Molecular INTeraction database

More...
MINTi
Q5ZSM7

STRING: functional protein association networks

More...
STRINGi
272624.lpg2490

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5ZSM7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini125 – 305LepB_NInterPro annotationAdd BLAST181
Domaini331 – 522LepB_GAP_NInterPro annotationAdd BLAST192
Domaini534 – 612LepB_GAP_CInterPro annotationAdd BLAST79

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili625 – 673Sequence analysisAdd BLAST49
Coiled coili681 – 725Sequence analysisAdd BLAST45
Coiled coili740 – 805Sequence analysisAdd BLAST66
Coiled coili817 – 910Sequence analysisAdd BLAST94
Coiled coili915 – 977Sequence analysisAdd BLAST63
Coiled coili988 – 1078Sequence analysisAdd BLAST91
Coiled coili1089 – 1140Sequence analysisAdd BLAST52
Coiled coili1159 – 1179Sequence analysisAdd BLAST21
Coiled coili1211 – 1231Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410YNSE LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000278672

KEGG Orthology (KO)

More...
KOi
K15492

Identification of Orthologs from Complete Genome Data

More...
OMAi
THQEETI

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR040484 LepB_GAP_C
IPR041585 LepB_GAP_N
IPR040519 LepB_N

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF18227 LepB_GAP_C, 1 hit
PF18172 LepB_GAP_N, 1 hit
PF18640 LepB_N, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5ZSM7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLIYQGKEIV RFKEKTGGKN KSDVDGFYKD NDGGKFFIKK PGDPRELFTE
60 70 80 90 100
LFAGLLLKEF MKRGLIDESY FPSLICADVI QFEDKSYGLI QPLVSFDELH
110 120 130 140 150
KVIGTSSGDG KDRNTLKETL FGPGYYAGIT KQNKYFGLSM ALMFSLLLGA
160 170 180 190 200
HSVHSGNIVV LNGEEKEKSK QFGRIDWGDA FRYFAHPNNN DNLLYAYENR
210 220 230 240 250
GWFNYKSLTK DYFLNYKKIN GLFPAMAEKA RQLQSKLNPE LLVKIVTSAL
260 270 280 290 300
KNIPADLIDE KTKIQLAAYM CMDSFKEATF GTEGNCKDFA IAMATLLENR
310 320 330 340 350
LGKIAVLKDM SPLSNPEELY QSILELKPLT LLMTSSTSFS ETINQWADIL
360 370 380 390 400
KTTDMEKFSF DSNPINLLEL VKQFNLYVDE LAITCEANNV WAKERIDSTP
410 420 430 440 450
NLFALYDNSG GEAIHGHAFV PYYKESIVLR RLFTVDPNTF NLSRFAAFEG
460 470 480 490 500
PCQLYCKEHK DSAWVKIQTL LTLGNGIINT LKIIKQAQAF GIDEAVTENL
510 520 530 540 550
KALKEQFIAF QLAEADIKES LKAPSFAEPL PNKESEFFYP IDEKALAKMN
560 570 580 590 600
GYQLATICLE ELNSPKPSPL IERILSNKKF WKRINSAFES GVFKGRTDDP
610 620 630 640 650
AGKIAKIREW HQLLQISGKK TAGQIDELQK IVISLQSKIK RQTIEFEELE
660 670 680 690 700
ATLIQIKEKY QLLEKMAEQS EHEKSSAQSI IRSLNLELSQ LKLQLQEQEK
710 720 730 740 750
LQFQLKELKE KIHEQTTLSK RLGEELQTQK KTNTHQEETI QRITKEKSLA
760 770 780 790 800
DSSLESLRKE LHELAKKERS LHKTLEEKQL QVQQLEEQLA EKEKENLALK
810 820 830 840 850
KADKQSQHEK SLDKSAIESL TSELNQLKLE LQKQETLQLQ LKSLRKQIQE
860 870 880 890 900
QTLVVEGLKE ELQKQKKSNT HQEETIERIT KEKSLADSAL ESLRKEMYEL
910 920 930 940 950
TRKNEENQLK LTKQVHSLSE QLEEKQLQIR EFEKQLQEKE KRVEQSEKGK
960 970 980 990 1000
ASAKRTVASL REQVSNLKLQ LQQLGEVIQE KEKGSSLISQ QSKQIIALQE
1010 1020 1030 1040 1050
IIEDQKRQLE ELKIKIQELV SANQELGKQN QSLSKENLHN KNTVEDLKKK
1060 1070 1080 1090 1100
LNELNVQLEQ LHQSSNEKEQ TIRKLREELI KKDSSLKQNE EMQLAQKHLQ
1110 1120 1130 1140 1150
EEIDRLQKEI KQQQLNTNQL ESIIAQSKEA EKRYQQALQQ KKGIYFARME
1160 1170 1180 1190 1200
RVSPIYLQIQ QIEQKAKELE ERRETEASTA AKTLATKLRL EIKNYLDNNE
1210 1220 1230 1240 1250
SDEKSALNSF KINAKRHIEN SKETLNQHRE EWKYLLANVT LGVFLLGIGY
1260 1270 1280 1290
LAAILINKAT TGNYTFFSQT NSGKKLDALE KAISSTHSET LVYG
Length:1,294
Mass (Da):148,752
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDAAA3F035EA8B9B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AE017354 Genomic DNA Translation: AAU28550.1

NCBI Reference Sequences

More...
RefSeqi
WP_010948192.1, NC_002942.5
YP_096497.1, NC_002942.5

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAU28550; AAU28550; lpg2490

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
19834055

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lpn:lpg2490

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|272624.6.peg.2640

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE017354 Genomic DNA Translation: AAU28550.1
RefSeqiWP_010948192.1, NC_002942.5
YP_096497.1, NC_002942.5

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I1MX-ray2.80A/B/C317-618[»]
4I1OX-ray2.70B/D/F/H317-618[»]
4IRUX-ray3.20A/C/E326-623[»]
SMRiQ5ZSM7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

IntActiQ5ZSM7, 1 interactor
MINTiQ5ZSM7
STRINGi272624.lpg2490

Proteomic databases

PaxDbiQ5ZSM7

Genome annotation databases

EnsemblBacteriaiAAU28550; AAU28550; lpg2490
GeneIDi19834055
KEGGilpn:lpg2490
PATRICifig|272624.6.peg.2640

Phylogenomic databases

eggNOGiENOG410YNSE LUCA
HOGENOMiHOG000278672
KOiK15492
OMAiTHQEETI

Family and domain databases

InterProiView protein in InterPro
IPR040484 LepB_GAP_C
IPR041585 LepB_GAP_N
IPR040519 LepB_N
PfamiView protein in Pfam
PF18227 LepB_GAP_C, 1 hit
PF18172 LepB_GAP_N, 1 hit
PF18640 LepB_N, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ5ZSM7_LEGPH
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5ZSM7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: May 8, 2019
This is version 80 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported
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Main funding by: National Institutes of Health

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