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Entry version 138 (13 Feb 2019)
Sequence version 1 (23 Nov 2004)
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Protein

CD276 antigen

Gene

CD276

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling.6 Publications

Miscellaneous

B7-H3 locus underwent genomic duplication leading to tandemly repeated immunoglobulin-like V and C domains (VC domains). The dominantly expressed human B7-H3 isoform contains tandemly duplicated VC domains. In contrast, mouse B7-H3 transcript contains only one single VC domain form due to an exon structure corresponding to V domain-(pseudoexon C)-(pseudoexon V)-C domain. This duplication appearing in primates is suggested to be very recent supporting a model of multiple independent emergence of tandem VC repeats within human and monkey species.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • signaling receptor binding Source: GO_Central

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
CD276 antigen
Alternative name(s):
4Ig-B7-H3
B7 homolog 3
Short name:
B7-H3
Costimulatory molecule
CD_antigen: CD276
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CD276
Synonyms:B7H3
ORF Names:PSEC0249, UNQ309/PRO352
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000103855.17

Human Gene Nomenclature Database

More...
HGNCi
HGNC:19137 CD276

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
605715 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q5ZPR3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 466ExtracellularSequence analysisAdd BLAST438
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei467 – 487HelicalSequence analysisAdd BLAST21
Topological domaini488 – 534CytoplasmicSequence analysisAdd BLAST47

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
80381

Open Targets

More...
OpenTargetsi
ENSG00000103855

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA142672148

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3712879

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
2938

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CD276

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74757248

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 281 PublicationAdd BLAST28
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000004580129 – 534CD276 antigenAdd BLAST506

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi50 ↔ 122PROSITE-ProRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi104N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi165 ↔ 220PROSITE-ProRule annotation
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi268 ↔ 340PROSITE-ProRule annotation
Glycosylationi322N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi383 ↔ 438PROSITE-ProRule annotation
Glycosylationi407N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei525PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q5ZPR3

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q5ZPR3

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q5ZPR3

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5ZPR3

PeptideAtlas

More...
PeptideAtlasi
Q5ZPR3

PRoteomics IDEntifications database

More...
PRIDEi
Q5ZPR3

ProteomicsDB human proteome resource

More...
ProteomicsDBi
65865
65866 [Q5ZPR3-2]
65867 [Q5ZPR3-3]
65868 [Q5ZPR3-4]

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
1087

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q5ZPR3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q5ZPR3

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q5ZPR3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitous but not detectable in peripheral blood lymphocytes or granulocytes. Weakly expressed in resting monocytes. Expressed in dendritic cells derived from monocytes. Expressed in epithelial cells of sinonasal tissue. Expressed in extravillous trophoblast cells and Hofbauer cells of the first trimester placenta and term placenta.5 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By bacterial lipopolysaccharides (LPS) in monocytes and by ionomycin in T and B-lymphocytes. Up-regulated in cells mediating rejection of human transplants.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000103855 Expressed in 188 organ(s), highest expression level in layer of synovial tissue

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q5ZPR3 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q5ZPR3 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB017826
HPA009285
HPA017139

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with TREML2 and this interaction enhances T-cell activation.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
123260, 13 interactors

Protein interaction database and analysis system

More...
IntActi
Q5ZPR3, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320084

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q5ZPR3

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5ZPR3

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini29 – 139Ig-like V-type 1Add BLAST111
Domaini145 – 238Ig-like C2-type 1Add BLAST94
Domaini243 – 357Ig-like V-type 2Add BLAST115
Domaini363 – 456Ig-like C2-type 2Add BLAST94

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IR2H Eukaryota
ENOG410ZB69 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154641

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG079786

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5ZPR3

KEGG Orthology (KO)

More...
KOi
K06746

Identification of Orthologs from Complete Genome Data

More...
OMAi
SLENWYD

Database of Orthologous Groups

More...
OrthoDBi
1162336at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5ZPR3

TreeFam database of animal gene trees

More...
TreeFami
TF331083

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07686 V-set, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 4 hits
SM00407 IGc1, 2 hits
SM00408 IGc2, 4 hits
SM00406 IGv, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q5ZPR3-1) [UniParc]FASTAAdd to basket
Also known as: 4Ig-B7-H3

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC
60 70 80 90 100
SFSPEPGFSL AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL
110 120 130 140 150
AQGNASLRLQ RVRVADEGSF TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE
160 170 180 190 200
PNKDLRPGDT VTITCSSYQG YPEAEVFWQD GQGVPLTGNV TTSQMANEQG
210 220 230 240 250
LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ RSPTGAVEVQ
260 270 280 290 300
VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG
310 320 330 340 350
RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA
360 370 380 390 400
AVSLQVAAPY SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ
410 420 430 440 450
GVPLTGNVTT SQMANEQGLF DVHSVLRVVL GANGTYSCLV RNPVLQQDAH
460 470 480 490 500
GSVTITGQPM TFPPEALWVT VGLSVCLIAL LVALAFVCWR KIKQSCEEEN
510 520 530
AGAEDQDGEG EGSKTALQPL KHSDSKEDDG QEIA
Note: Contains tandemly repeated immunoglobulin-like V and C domains.
Length:534
Mass (Da):57,235
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2181A064404C7939
GO
Isoform 2 (identifier: Q5ZPR3-2) [UniParc]FASTAAdd to basket
Also known as: B7-H3

The sequence of this isoform differs from the canonical sequence as follows:
     159-376: Missing.

Note: Minor transcript. Contains one single set of immunoglobulin-like V and C domains.
Show »
Length:316
Mass (Da):33,791
Checksum:iFF97007F191CCFA1
GO
Isoform 3 (identifier: Q5ZPR3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     465-493: EALWVTVGLSVCLIALLVALAFVCWRKIK → GPASSAVPLSPAHPPHGSMCWSHWFSRGL
     494-534: Missing.

Note: Contains tandemly repeated immunoglobulin-like V and C domains.
Show »
Length:493
Mass (Da):52,761
Checksum:iCD7C5591CC4822D2
GO
Isoform 4 (identifier: Q5ZPR3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     528-534: DDGQEIA → GKDTWA

Note: Contains tandemly repeated immunoglobulin-like V and C domains.
Show »
Length:533
Mass (Da):57,165
Checksum:iBC38033295EBE978
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0C4DGH0A0A0C4DGH0_HUMAN
CD276 antigen
CD276
388Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN29H0YN29_HUMAN
CD276 antigen
CD276
170Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL10H0YL10_HUMAN
CD276 antigen
CD276
199Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK59H0YK59_HUMAN
CD276 antigen
CD276
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN85H0YN85_HUMAN
CD276 antigen
CD276
136Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YK40H0YK40_HUMAN
CD276 antigen
CD276
156Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLT8H0YLT8_HUMAN
CD276 antigen
CD276
132Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YKQ9H0YKQ9_HUMAN
CD276 antigen
CD276
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H3BM68H3BM68_HUMAN
CD276 antigen
CD276
146Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLT3H0YLT3_HUMAN
CD276 antigen
CD276
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC11344 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti387R → Q in AAQ88709 (PubMed:12975309).Curated1
Sequence conflicti473L → P in BAC11243 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04985797P → L. Corresponds to variant dbSNP:rs7173448Ensembl.1
Natural variantiVAR_049858111R → S. Corresponds to variant dbSNP:rs7173476Ensembl.1
Natural variantiVAR_049859137Q → L. Corresponds to variant dbSNP:rs11574477Ensembl.1
Natural variantiVAR_049860160T → M2 PublicationsCorresponds to variant dbSNP:rs11574479Ensembl.1
Natural variantiVAR_049861267R → H. Corresponds to variant dbSNP:rs11574483Ensembl.1
Natural variantiVAR_049862279A → T. Corresponds to variant dbSNP:rs10083681Ensembl.1
Natural variantiVAR_049863315P → L. Corresponds to variant dbSNP:rs148625372Ensembl.1
Natural variantiVAR_049864329R → S. Corresponds to variant dbSNP:rs7173476Ensembl.1
Natural variantiVAR_049865378T → M. Corresponds to variant dbSNP:rs11574479Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_017088159 – 376Missing in isoform 2. 2 PublicationsAdd BLAST218
Alternative sequenceiVSP_017089465 – 493EALWV…WRKIK → GPASSAVPLSPAHPPHGSMC WSHWFSRGL in isoform 3. 1 PublicationAdd BLAST29
Alternative sequenceiVSP_017090494 – 534Missing in isoform 3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_017091528 – 534DDGQEIA → GKDTWA in isoform 4. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF302102 mRNA Translation: AAK15438.1
AJ583695 mRNA Translation: CAE47548.1
AY358343 mRNA Translation: AAQ88709.1
AK074849 mRNA Translation: BAC11243.1
AK074997 mRNA Translation: BAC11344.1 Different initiation.
AK075549 mRNA Translation: BAC11692.1
BC062581 mRNA Translation: AAH62581.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS10251.1 [Q5ZPR3-2]
CCDS32288.1 [Q5ZPR3-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001019907.1, NM_001024736.1 [Q5ZPR3-1]
NP_001316557.1, NM_001329628.1 [Q5ZPR3-2]
NP_001316558.1, NM_001329629.1
NP_079516.1, NM_025240.2 [Q5ZPR3-2]
XP_005254757.1, XM_005254700.4 [Q5ZPR3-1]
XP_011520397.1, XM_011522095.2 [Q5ZPR3-1]
XP_011520398.1, XM_011522096.2
XP_016878127.1, XM_017022638.1 [Q5ZPR3-1]

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.744915

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000318424; ENSP00000320058; ENSG00000103855 [Q5ZPR3-2]
ENST00000318443; ENSP00000320084; ENSG00000103855 [Q5ZPR3-1]
ENST00000561213; ENSP00000452736; ENSG00000103855 [Q5ZPR3-4]
ENST00000564751; ENSP00000454940; ENSG00000103855 [Q5ZPR3-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80381

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:80381

UCSC genome browser

More...
UCSCi
uc002avu.2 human [Q5ZPR3-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF302102 mRNA Translation: AAK15438.1
AJ583695 mRNA Translation: CAE47548.1
AY358343 mRNA Translation: AAQ88709.1
AK074849 mRNA Translation: BAC11243.1
AK074997 mRNA Translation: BAC11344.1 Different initiation.
AK075549 mRNA Translation: BAC11692.1
BC062581 mRNA Translation: AAH62581.1
CCDSiCCDS10251.1 [Q5ZPR3-2]
CCDS32288.1 [Q5ZPR3-1]
RefSeqiNP_001019907.1, NM_001024736.1 [Q5ZPR3-1]
NP_001316557.1, NM_001329628.1 [Q5ZPR3-2]
NP_001316558.1, NM_001329629.1
NP_079516.1, NM_025240.2 [Q5ZPR3-2]
XP_005254757.1, XM_005254700.4 [Q5ZPR3-1]
XP_011520397.1, XM_011522095.2 [Q5ZPR3-1]
XP_011520398.1, XM_011522096.2
XP_016878127.1, XM_017022638.1 [Q5ZPR3-1]
UniGeneiHs.744915

3D structure databases

ProteinModelPortaliQ5ZPR3
SMRiQ5ZPR3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi123260, 13 interactors
IntActiQ5ZPR3, 1 interactor
STRINGi9606.ENSP00000320084

Chemistry databases

ChEMBLiCHEMBL3712879
GuidetoPHARMACOLOGYi2938

PTM databases

GlyConnecti1087
iPTMnetiQ5ZPR3
PhosphoSitePlusiQ5ZPR3
SwissPalmiQ5ZPR3

Polymorphism and mutation databases

BioMutaiCD276
DMDMi74757248

Proteomic databases

EPDiQ5ZPR3
jPOSTiQ5ZPR3
MaxQBiQ5ZPR3
PaxDbiQ5ZPR3
PeptideAtlasiQ5ZPR3
PRIDEiQ5ZPR3
ProteomicsDBi65865
65866 [Q5ZPR3-2]
65867 [Q5ZPR3-3]
65868 [Q5ZPR3-4]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000318424; ENSP00000320058; ENSG00000103855 [Q5ZPR3-2]
ENST00000318443; ENSP00000320084; ENSG00000103855 [Q5ZPR3-1]
ENST00000561213; ENSP00000452736; ENSG00000103855 [Q5ZPR3-4]
ENST00000564751; ENSP00000454940; ENSG00000103855 [Q5ZPR3-2]
GeneIDi80381
KEGGihsa:80381
UCSCiuc002avu.2 human [Q5ZPR3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
80381
DisGeNETi80381
EuPathDBiHostDB:ENSG00000103855.17

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CD276
HGNCiHGNC:19137 CD276
HPAiCAB017826
HPA009285
HPA017139
MIMi605715 gene
neXtProtiNX_Q5ZPR3
OpenTargetsiENSG00000103855
PharmGKBiPA142672148

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IR2H Eukaryota
ENOG410ZB69 LUCA
GeneTreeiENSGT00940000154641
HOVERGENiHBG079786
InParanoidiQ5ZPR3
KOiK06746
OMAiSLENWYD
OrthoDBi1162336at2759
PhylomeDBiQ5ZPR3
TreeFamiTF331083

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
CD276 human

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CD276

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
80381

Protein Ontology

More...
PROi
PR:Q5ZPR3

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000103855 Expressed in 188 organ(s), highest expression level in layer of synovial tissue
ExpressionAtlasiQ5ZPR3 baseline and differential
GenevisibleiQ5ZPR3 HS

Family and domain databases

Gene3Di2.60.40.10, 4 hits
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR003597 Ig_C1-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
PfamiView protein in Pfam
PF07686 V-set, 2 hits
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00407 IGc1, 2 hits
SM00408 IGc2, 4 hits
SM00406 IGv, 2 hits
SUPFAMiSSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD276_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5ZPR3
Secondary accession number(s): Q6P5Y4
, Q6UXI2, Q8NBI8, Q8NC34, Q8NCB6, Q9BXR1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2006
Last sequence update: November 23, 2004
Last modified: February 13, 2019
This is version 138 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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