UniProtKB - Q5ZMW3 (API5_CHICK)
Protein
Apoptosis inhibitor 5
Gene
API5
Organism
Gallus gallus (Chicken)
Status
Functioni
Antiapoptotic factor that may have a role in protein assembly.By similarity
GO - Molecular functioni
- fibroblast growth factor binding Source: UniProtKB
- RNA binding Source: GO_Central
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- negative regulation of apoptotic process Source: UniProtKB
Keywordsi
Biological process | Apoptosis |
Names & Taxonomyi
Protein namesi | Recommended name: Apoptosis inhibitor 5Short name: API-5 |
Gene namesi | Name:API5 ORF Names:RCJMB04_1a12 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000064633 | 1 – 523 | Apoptosis inhibitor 5Add BLAST | 523 |
Proteomic databases
PaxDbi | Q5ZMW3 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000007977, Expressed in spleen and 14 other tissues |
ExpressionAtlasi | Q5ZMW3, baseline and differential |
Interactioni
Subunit structurei
Monomer.
By similarityGO - Molecular functioni
- fibroblast growth factor binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000012938 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 360 | ARM-like and Heat-like helical repeatsBy similarityAdd BLAST | 360 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 454 – 475 | Nuclear localization signalBy similarityAdd BLAST | 22 |
Sequence similaritiesi
Belongs to the API5 family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG2213, Eukaryota |
GeneTreei | ENSGT00390000010991 |
HOGENOMi | CLU_037809_1_0_1 |
InParanoidi | Q5ZMW3 |
OrthoDBi | 1385954at2759 |
PhylomeDBi | Q5ZMW3 |
Family and domain databases
InterProi | View protein in InterPro IPR008383, API5 IPR016024, ARM-type_fold |
PANTHERi | PTHR12758, PTHR12758, 1 hit |
Pfami | View protein in Pfam PF05918, API5, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q5ZMW3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPTVEELYRN YGILADATET AGQHKDAYQV ILDGVKGGAK EKRLAAQFIP
60 70 80 90 100
KFFKHFPELA DSAINAQLDL CEDEDVSIRR QAIKELPQFA TGDNLPRVAD
110 120 130 140 150
ILTQLLQSDD SAEFNLVNNA LLSIFKMDAK GTLGGLFSQI LQGEDIVRER
160 170 180 190 200
AIKFLSTKLK TLPEEVLTKE VEEFILAESK KVLEDVTGEE FVLFMKILSG
210 220 230 240 250
LKSLQTVSGR QQLVELVAEQ ADLEQTFNPS DPDCVDRLLQ CTRQAVPLFS
260 270 280 290 300
KNVHSTKFVT YFCEHVLPNL SALTTPVEGL DIQLEVLKLL AEMSSFCGDM
310 320 330 340 350
EKLESNLKKL FDKLLEYMPL PPEEAENGEN AGGEEPKLQF SYVECLLYSF
360 370 380 390 400
HQLGRKLPDF LTAKLNAEKL KDFKIRLQYF ARGLQVYIRQ LRLALQGKTG
410 420 430 440 450
EALKTEENKI KVVALKITNN INVLIKDLFH IPPSYKSTVT LSWKPVQKAD
460 470 480 490 500
ANQKRTSEDT TSSSPPKKAS AGPKRDARQI YNPPSGKYSS NLGSFSYEQR
510 520
GGFRGGRGRG WGGRGNRSRG RIY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3Q2U9L4 | A0A3Q2U9L4_CHICK | Apoptosis inhibitor 5 | API5 | 526 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719271 mRNA Translation: CAG30930.1 |
RefSeqi | NP_001006474.1, NM_001006474.1 |
Genome annotation databases
Ensembli | ENSGALT00000061756; ENSGALP00000054380; ENSGALG00000037968 |
GeneIDi | 423168 |
KEGGi | gga:423168 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719271 mRNA Translation: CAG30930.1 |
RefSeqi | NP_001006474.1, NM_001006474.1 |
3D structure databases
SMRi | Q5ZMW3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000012938 |
Proteomic databases
PaxDbi | Q5ZMW3 |
Genome annotation databases
Ensembli | ENSGALT00000061756; ENSGALP00000054380; ENSGALG00000037968 |
GeneIDi | 423168 |
KEGGi | gga:423168 |
Organism-specific databases
CTDi | 8539 |
Phylogenomic databases
eggNOGi | KOG2213, Eukaryota |
GeneTreei | ENSGT00390000010991 |
HOGENOMi | CLU_037809_1_0_1 |
InParanoidi | Q5ZMW3 |
OrthoDBi | 1385954at2759 |
PhylomeDBi | Q5ZMW3 |
Miscellaneous databases
PROi | PR:Q5ZMW3 |
Gene expression databases
Bgeei | ENSGALG00000007977, Expressed in spleen and 14 other tissues |
ExpressionAtlasi | Q5ZMW3, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR008383, API5 IPR016024, ARM-type_fold |
PANTHERi | PTHR12758, PTHR12758, 1 hit |
Pfami | View protein in Pfam PF05918, API5, 1 hit |
SUPFAMi | SSF48371, SSF48371, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | API5_CHICK | |
Accessioni | Q5ZMW3Primary (citable) accession number: Q5ZMW3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | March 29, 2005 |
Last sequence update: | November 23, 2004 | |
Last modified: | October 7, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families