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Protein

Prohibitin-2

Gene

PHB2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases. Functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. Competes with NCOA1 for modulation of ER transcriptional activity. Probably involved in regulating mitochondrial respiration activity and in aging (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor, Repressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Prohibitin-2
Gene namesi
Name:PHB2
ORF Names:RCJMB04_1i23
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane, Mitochondrion, Mitochondrion inner membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003286531 – 301Prohibitin-2Add BLAST301

Proteomic databases

PaxDbiQ5ZMN3
PRIDEiQ5ZMN3

Interactioni

Protein-protein interaction databases

BioGridi691830, 2 interactors
STRINGi9031.ENSGALP00000023446

Structurei

3D structure databases

ProteinModelPortaliQ5ZMN3
SMRiQ5ZMN3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni19 – 49Necessary for transcriptional repressionBy similarityAdd BLAST31
Regioni150 – 174Necessary for transcriptional repressionBy similarityAdd BLAST25

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili190 – 237Sequence analysisAdd BLAST48

Sequence similaritiesi

Belongs to the prohibitin family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3090 Eukaryota
COG0330 LUCA
HOGENOMiHOG000205692
HOVERGENiHBG004457
InParanoidiQ5ZMN3
KOiK17081
PhylomeDBiQ5ZMN3

Family and domain databases

CDDicd03401 SPFH_prohibitin, 1 hit
InterProiView protein in InterPro
IPR001107 Band_7
IPR036013 Band_7/SPFH_dom_sf
IPR000163 Prohibitin
PANTHERiPTHR23222 PTHR23222, 1 hit
PfamiView protein in Pfam
PF01145 Band_7, 1 hit
PRINTSiPR00679 PROHIBITIN
SMARTiView protein in SMART
SM00244 PHB, 1 hit
SUPFAMiSSF117892 SSF117892, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZMN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSLKDLAG RLPAGPRGVG TALKLLLGAG ALAYGVRESV FIVEGGQRAI
60 70 80 90 100
FFNRIGGVQQ DTILAEGLHF RIPWFQYPII YDIRARPRKI SSPTGSKDLQ
110 120 130 140 150
MVNISLRVLT RPNAAELPSM YQRLGLDYEE RVLPSIVNEV LKSVVAKFNA
160 170 180 190 200
SQLITQRAQV SLLIRRELTE RAKDFSLILD DVAITELSFS REYTAAVEAK
210 220 230 240 250
QVAQQEAQRA QFLVEKAKQE QKQKIVQAEG EATAAKMLGE ALSRNPGYIK
260 270 280 290 300
LRKIRAAQNI SKTIAGSQNR VYLTADNLVL NLQDEGFTRG SDSLLLKQGK

K
Length:301
Mass (Da):33,337
Last modified:November 23, 2004 - v1
Checksum:iB43E2C8178F21BB4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719351 mRNA Translation: CAG31010.1
RefSeqiNP_001074354.1, NM_001080885.1
UniGeneiGga.34471

Genome annotation databases

GeneIDi771124
KEGGigga:771124

Similar proteinsi

Entry informationi

Entry nameiPHB2_CHICK
AccessioniPrimary (citable) accession number: Q5ZMN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: November 23, 2004
Last modified: July 18, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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