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Protein

Major vault protein

Gene

MVP

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein

Names & Taxonomyi

Protein namesi
Recommended name:
Major vault protein
Short name:
MVP
Gene namesi
Name:MVP
ORF Names:RCJMB04_1p8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002474891 – 849Major vault proteinAdd BLAST849

Proteomic databases

PRIDEiQ5ZMI4

Interactioni

Subunit structurei

The vault ribonucleoprotein particle is a huge (400 A x 670 A) cage structure of 12.9 MDa. It consists of a dimer of half-vaults, with each half-vault comprising 39 identical major vault protein (MVP) chains, PARP4 and one or more vault RNAs (vRNAs) (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ5ZMI4
SMRiQ5ZMI4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati2 – 54MVP 1Add BLAST53
Repeati55 – 109MVP 2Add BLAST55
Repeati110 – 162MVP 3Add BLAST53
Repeati163 – 215MVP 4Add BLAST53
Repeati216 – 270MVP 5Add BLAST55
Repeati271 – 321MVP 6Add BLAST51
Repeati322 – 378MVP 7Add BLAST57
Repeati379 – 458MVP 8Add BLAST80
Repeati459 – 521MVP 9Add BLAST63

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG003499
InParanoidiQ5ZMI4
KOiK17266
PhylomeDBiQ5ZMI4

Family and domain databases

CDDicd08825 MVP_shoulder, 1 hit
InterProiView protein in InterPro
IPR039059 MVP
IPR021870 MVP_shoulder
IPR002499 Vault_N
PANTHERiPTHR14165 PTHR14165, 1 hit
PfamiView protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PROSITEiView protein in PROSITE
PS51224 MVP, 8 hits

Sequencei

Sequence statusi: Complete.

Q5ZMI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDPVIRIPP YHYIHVLDLN SNVTRVEVGP HSFIRQDHER VVFSPKRMVM
60 70 80 90 100
VPPRHYCVVL NPVARGPTGA VLFDGAGQAQ LRHADLDIRL TQEPFPLYPG
110 120 130 140 150
EELQQGVTPL QVVLADTALR LRALLDFEDE DGNKFVAGDE WLFEGPGTYI
160 170 180 190 200
PHKEVEVVET LQATIIRHNQ AIRLRARKEC LDRQGTRRVT GEEWLVKRVG
210 220 230 240 250
AYLPGVYEEV VDVVDAYVLT DKKALHLRAT RTFEDVQGHV RRTGEEWLVT
260 270 280 290 300
QEQSEAYVPD VFEEVVAEVL VTTLGPRQYC VVLDPVGPNG QPQLGQQRVV
310 320 330 340 350
KGEKSFFLQP GERLQAGIQD VYVLSEDEGL LLQALQTIKD TDEDGTEVIR
360 370 380 390 400
RAGDRWLARG PLEYVPPAEV TVLERRQALA LAENEGIYVR DIRTGKVRVV
410 420 430 440 450
TGQTYMLTES EELWEKELPP GVEVLLAEAR GDTAGQDSGI QSSSGPSFGV
460 470 480 490 500
QERDRTRAVT YQVPHNAAVQ VYDYRERRAR VVLGPELVVL GPGEQLTVLS
510 520 530 540 550
LSGGRPKRPH ARRSLCLRLG PDFCADIVTI ETADHARLQL QLAYNWHFEV
560 570 580 590 600
PEDPKALGRL FSVPDFVGDA CKALASRVRG AVAAVTFDDF HKNSNRLICS
610 620 630 640 650
AVFGFDEGGR LREHLRFVPN GLVVTSVDIQ SVEPVDQRTR DALQRSVQLA
660 670 680 690 700
IEIATNSQEA AARHEAERLA QEARVRLERQ RLLDQAEAER ARRELLELEA
710 720 730 740 750
LSAAVESAGA ARAEAQARAE AARIEAEAAI LQAKLKAEAV AIETEAELAR
760 770 780 790 800
LERMQAQEVR AQRARAEAEA ARAQALAAVE ASKVREVAAA LGPETIRDIA
810 820 830 840
RAGPELQVKL LQGLGLQSAL ITDGAAPLNL FSTARGLLGL AVPPEPSTS
Length:849
Mass (Da):93,822
Last modified:November 23, 2004 - v1
Checksum:i299ABAC7F818170A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719400 mRNA Translation: CAG31059.1
RefSeqiNP_001006336.1, NM_001006336.1
UniGeneiGga.1749

Genome annotation databases

GeneIDi420049
KEGGigga:420049

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719400 mRNA Translation: CAG31059.1
RefSeqiNP_001006336.1, NM_001006336.1
UniGeneiGga.1749

3D structure databases

ProteinModelPortaliQ5ZMI4
SMRiQ5ZMI4
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ5ZMI4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi420049
KEGGigga:420049

Organism-specific databases

CTDi9961

Phylogenomic databases

HOVERGENiHBG003499
InParanoidiQ5ZMI4
KOiK17266
PhylomeDBiQ5ZMI4

Miscellaneous databases

PROiPR:Q5ZMI4

Family and domain databases

CDDicd08825 MVP_shoulder, 1 hit
InterProiView protein in InterPro
IPR039059 MVP
IPR021870 MVP_shoulder
IPR002499 Vault_N
PANTHERiPTHR14165 PTHR14165, 1 hit
PfamiView protein in Pfam
PF11978 MVP_shoulder, 1 hit
PF01505 Vault, 4 hits
PROSITEiView protein in PROSITE
PS51224 MVP, 8 hits
ProtoNetiSearch...

Entry informationi

Entry nameiMVP_CHICK
AccessioniPrimary (citable) accession number: Q5ZMI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: November 23, 2004
Last modified: July 18, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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