UniProtKB - Q5ZM98 (GRP75_CHICK)
Protein
Stress-70 protein, mitochondrial
Gene
HSPA9
Organism
Gallus gallus (Chicken)
Status
Functioni
Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU. Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging.By similarity
GO - Molecular functioni
- ATPase activity Source: GO_Central
- ATP binding Source: GO_Central
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- protein folding chaperone Source: GO_Central
- unfolded protein binding Source: GO_Central
GO - Biological processi
- cellular response to unfolded protein Source: GO_Central
- chaperone cofactor-dependent protein refolding Source: GO_Central
- erythrocyte differentiation Source: UniProtKB
- iron-sulfur cluster assembly Source: UniProtKB
- negative regulation of erythrocyte differentiation Source: UniProtKB
- negative regulation of hematopoietic stem cell differentiation Source: UniProtKB
- negative regulation of hemopoiesis Source: UniProtKB
- protein refolding Source: GO_Central
- regulation of erythrocyte differentiation Source: UniProtKB
Keywordsi
Molecular function | Chaperone |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Stress-70 protein, mitochondrialAlternative name(s): 75 kDa glucose-regulated protein Short name: GRP-75 Heat shock 70 kDa protein 9 |
Gene namesi | Name:HSPA9By similarity ORF Names:RCJMB04_2m8 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Mitochondrion
- Mitochondrion By similarity
Mitochondrion
- mitochondrion Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 48 | MitochondrionBy similarityAdd BLAST | 48 | |
ChainiPRO_0000223503 | 49 – 675 | Stress-70 protein, mitochondrialAdd BLAST | 627 |
Proteomic databases
PaxDbi | Q5ZM98 |
Interactioni
Subunit structurei
Interacts strongly with the intermediate form of FXN and weakly with its mature form. Associates with the mitochondrial contact site and cristae organizing system (MICOS) complex (also known as MINOS or MitOS complex).
By similarityGO - Molecular functioni
- heat shock protein binding Source: GO_Central
- misfolded protein binding Source: GO_Central
- unfolded protein binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 677728, 2 interactors |
STRINGi | 9031.ENSGALP00000003717 |
Family & Domainsi
Sequence similaritiesi
Belongs to the heat shock protein 70 family.Sequence analysis
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG0102, Eukaryota |
InParanoidi | Q5ZM98 |
OrthoDBi | 288077at2759 |
PhylomeDBi | Q5ZM98 |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
HAMAPi | MF_00332, DnaK, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR012725, Chaperone_DnaK IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR02350, prok_dnaK, 1 hit |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5ZM98-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MISASRAAAR LPLLLPRGGP VPAVPGLAQT FWNGLSQNVL RAASSRKYAS
60 70 80 90 100
EAIKGAVIGI DLGTTNSCVA VMEGKQAKVL ENSEGARTTP SVVAFTADGE
110 120 130 140 150
RLVGMPAKRQ AVTNPHNTFY ATKRLIGRRF DDSEVKKDIK NVPFKIVRAS
160 170 180 190 200
NGDAWVEAHG KLYSPSQIGA FVLMKMKETA ENYLGHPAKN AVITVPAYFN
210 220 230 240 250
DSQRQATKDA GQISGLNVLR VINEPTAAAL AYGLDKSEDK IIAVYDLGGG
260 270 280 290 300
TFDISILEIQ KGVFEVKSTN GDTFLGGEDF DQALLQYIVK EFKRETSVDL
310 320 330 340 350
TKDNMALQRV REASEKAKCE LSSSVQTDIN LPYLTMDASG PKHLNMKLSR
360 370 380 390 400
SQFEGIVADL IKRTVAPCQK AMQDAEVSKS DIGEVILVGG MTRMPKVQQT
410 420 430 440 450
VQDLFGRAPS KAVNPDEAVA IGAAIQGGVL AGDVTDVLLL DVTPLSLGIE
460 470 480 490 500
TLGGVFTKLI NRNTTIPTKK SQVFSTAADG QTQVEIKVCQ GEREMASDNK
510 520 530 540 550
LLGQFTLVGI PPAPRGVPQI EVTFDIDANG IVHVSAKDKG TGREQQIVIQ
560 570 580 590 600
SSGGLSKDEI ENMVKNAEKY AEEDRRRKER VEAVNLAEGI IHDTESKMEE
610 620 630 640 650
FKDQLPADEC NKLKEEIAKM RELLARKDTE TGENIRQAAT SLQQASLKLF
660 670
EMAYKKMASE RESSGSSGDQ KEEKQ
Mass spectrometryi
Molecular mass is 73967±2 Da. Determined by MALDI. 1 Publication
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719486 mRNA Translation: CAG31145.1 |
RefSeqi | NP_001006147.1, NM_001006147.1 |
Genome annotation databases
GeneIDi | 416183 |
KEGGi | gga:416183 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719486 mRNA Translation: CAG31145.1 |
RefSeqi | NP_001006147.1, NM_001006147.1 |
3D structure databases
SMRi | Q5ZM98 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 677728, 2 interactors |
STRINGi | 9031.ENSGALP00000003717 |
Proteomic databases
PaxDbi | Q5ZM98 |
Genome annotation databases
GeneIDi | 416183 |
KEGGi | gga:416183 |
Organism-specific databases
CTDi | 3313 |
Phylogenomic databases
eggNOGi | KOG0102, Eukaryota |
InParanoidi | Q5ZM98 |
OrthoDBi | 288077at2759 |
PhylomeDBi | Q5ZM98 |
Miscellaneous databases
PROi | PR:Q5ZM98 |
Family and domain databases
Gene3Di | 1.20.1270.10, 1 hit 2.60.34.10, 1 hit |
HAMAPi | MF_00332, DnaK, 1 hit |
InterProi | View protein in InterPro IPR043129, ATPase_NBD IPR012725, Chaperone_DnaK IPR018181, Heat_shock_70_CS IPR029048, HSP70_C_sf IPR029047, HSP70_peptide-bd_sf IPR013126, Hsp_70_fam |
PANTHERi | PTHR19375, PTHR19375, 1 hit |
Pfami | View protein in Pfam PF00012, HSP70, 1 hit |
SUPFAMi | SSF100920, SSF100920, 1 hit SSF53067, SSF53067, 2 hits |
TIGRFAMsi | TIGR02350, prok_dnaK, 1 hit |
PROSITEi | View protein in PROSITE PS00297, HSP70_1, 1 hit PS00329, HSP70_2, 1 hit PS01036, HSP70_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GRP75_CHICK | |
Accessioni | Q5ZM98Primary (citable) accession number: Q5ZM98 Secondary accession number(s): P84163 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 21, 2006 |
Last sequence update: | November 23, 2004 | |
Last modified: | April 7, 2021 | |
This is version 99 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families