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Protein

Regulation of nuclear pre-mRNA domain-containing protein 1A

Gene

RPRD1A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. May act as a negative regulator of cyclin-D1 (CCND1) and cyclin-E (CCNE1) in the cell cycle.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Regulation of nuclear pre-mRNA domain-containing protein 1A
Alternative name(s):
Cyclin-dependent kinase inhibitor 2B-related protein
p15INK4B-related protein
Gene namesi
Name:RPRD1A
Synonyms:P15RS
ORF Names:RCJMB04_3f10
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003113471 – 268Regulation of nuclear pre-mRNA domain-containing protein 1AAdd BLAST268

Proteomic databases

PaxDbiQ5ZM30

Interactioni

Subunit structurei

May form a heterodimer with RPRD1B. Associates with the RNA polymerase II subunit POLR2A (via CTD phosphorylated at 'Ser-2' and 'Ser-7' of the heptad repeats).By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021401

Structurei

3D structure databases

ProteinModelPortaliQ5ZM30
SMRiQ5ZM30
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 133CIDPROSITE-ProRule annotationAdd BLAST133

Sequence similaritiesi

Belongs to the UPF0400 (RTT103) family.Curated

Phylogenomic databases

eggNOGiKOG2669 Eukaryota
ENOG410XRAP LUCA
HOGENOMiHOG000007456
HOVERGENiHBG051177
InParanoidiQ5ZM30
PhylomeDBiQ5ZM30

Family and domain databases

CDDicd03562 CID, 1 hit
Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR032337 CREPT
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd
PfamiView protein in Pfam
PF16566 CREPT, 1 hit
PF04818 CTD_bind, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZM30-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAFSEAALE RKLSELSNSQ QSVQTLSLWL IHHRKHSALI VSVWERELRK
60 70 80 90 100
AKPNRKLTFL YLANDVIQNS KRKGPEFTKD FAPVIVEAFK HVSSESDESC
110 120 130 140 150
KKHPGRVLSI WEERSVYEND VLEQLRQALY GDRKVRKRTY EQIKVDENNC
160 170 180 190 200
SPRSSPTDPP QTMDLIRALQ ELENAASGDA AVHQRIASLP IEVQDVSLLD
210 220 230 240 250
RITDKESGEQ LSKMVDDACM LLADYNGRLA AEIDDRKQLT RMLSDFLRCQ
260
KEFLAEKEHK LEVRIVLF
Length:268
Mass (Da):30,836
Last modified:November 23, 2004 - v1
Checksum:i9E066A613F247AB2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719554 mRNA Translation: CAG31213.1
RefSeqiNP_001026176.1, NM_001031005.2
UniGeneiGga.12933

Genome annotation databases

GeneIDi420953
KEGGigga:420953

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719554 mRNA Translation: CAG31213.1
RefSeqiNP_001026176.1, NM_001031005.2
UniGeneiGga.12933

3D structure databases

ProteinModelPortaliQ5ZM30
SMRiQ5ZM30
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000021401

Proteomic databases

PaxDbiQ5ZM30

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi420953
KEGGigga:420953

Organism-specific databases

CTDi55197

Phylogenomic databases

eggNOGiKOG2669 Eukaryota
ENOG410XRAP LUCA
HOGENOMiHOG000007456
HOVERGENiHBG051177
InParanoidiQ5ZM30
PhylomeDBiQ5ZM30

Miscellaneous databases

PROiPR:Q5ZM30

Family and domain databases

CDDicd03562 CID, 1 hit
Gene3Di1.25.40.90, 1 hit
InterProiView protein in InterPro
IPR006569 CID_dom
IPR032337 CREPT
IPR008942 ENTH_VHS
IPR006903 RNA_pol_II-bd
PfamiView protein in Pfam
PF16566 CREPT, 1 hit
PF04818 CTD_bind, 1 hit
SMARTiView protein in SMART
SM00582 RPR, 1 hit
SUPFAMiSSF48464 SSF48464, 1 hit
PROSITEiView protein in PROSITE
PS51391 CID, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRPR1A_CHICK
AccessioniPrimary (citable) accession number: Q5ZM30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: November 23, 2004
Last modified: October 10, 2018
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries
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Main funding by: National Institutes of Health

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