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Protein

cAMP-regulated phosphoprotein 19

Gene

ARPP19

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. When phosphorylated at Ser-62 during mitosis, specifically interacts with PPP2R2D (PR55-delta) and inhibits its activity, leading to inactivation of PP2A, an essential condition to keep cyclin-B1-CDK1 activity high during M phase (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtein phosphatase inhibitor
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-GGA-2465910 MASTL Facilitates Mitotic Progression

Names & Taxonomyi

Protein namesi
Recommended name:
cAMP-regulated phosphoprotein 19
Short name:
ARPP-19
Gene namesi
Name:ARPP19
ORF Names:RCJMB04_4f12
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002359892 – 112cAMP-regulated phosphoprotein 19Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei62Phosphoserine; by GWLBy similarity1
Modified residuei104Phosphoserine; by PKABy similarity1

Post-translational modificationi

Phosphorylation at Ser-62 by GWL during mitosis is essential for interaction with PPP2R2D (PR55-delta) and subsequent inactivation of PP2A.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ5ZLY8
PRIDEiQ5ZLY8

Expressioni

Gene expression databases

BgeeiENSGALG00000017370 Expressed in 11 organ(s), highest expression level in brain

Interactioni

Subunit structurei

Interacts (when phosphorylated at Ser-62) with PPP2R2D.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028001

Family & Domainsi

Sequence similaritiesi

Belongs to the endosulfine family.Curated

Phylogenomic databases

eggNOGiKOG4076 Eukaryota
ENOG4112586 LUCA
GeneTreeiENSGT00390000010139
HOVERGENiHBG000297
InParanoidiQ5ZLY8
OMAiNEMEDKV
OrthoDBiEOG091G14MO
PhylomeDBiQ5ZLY8

Family and domain databases

InterProiView protein in InterPro
IPR006760 Endosulphine
PANTHERiPTHR10358 PTHR10358, 1 hit
PfamiView protein in Pfam
PF04667 Endosulfine, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZLY8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAESPEPAS AEEQKEMEDK VISPEKAEEA KLKARYPHLG QKPGGSDFLR
60 70 80 90 100
KRLQKGQKYF DSGDYNMAKA KMKNKQLPTA APDKTEVTGD HIPTPQDLPQ
110
RKPSLVASKL AG
Length:112
Mass (Da):12,349
Last modified:January 23, 2007 - v3
Checksum:i305C72895D0DB1A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719596 mRNA Translation: CAG31255.1
RefSeqiNP_001075176.1, NM_001081707.1
UniGeneiGga.22263
Gga.8380

Genome annotation databases

EnsembliENSGALT00000039081; ENSGALP00000038292; ENSGALG00000017370
GeneIDi768853
KEGGigga:768853

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719596 mRNA Translation: CAG31255.1
RefSeqiNP_001075176.1, NM_001081707.1
UniGeneiGga.22263
Gga.8380

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028001

Proteomic databases

PaxDbiQ5ZLY8
PRIDEiQ5ZLY8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000039081; ENSGALP00000038292; ENSGALG00000017370
GeneIDi768853
KEGGigga:768853

Organism-specific databases

CTDi10776

Phylogenomic databases

eggNOGiKOG4076 Eukaryota
ENOG4112586 LUCA
GeneTreeiENSGT00390000010139
HOVERGENiHBG000297
InParanoidiQ5ZLY8
OMAiNEMEDKV
OrthoDBiEOG091G14MO
PhylomeDBiQ5ZLY8

Enzyme and pathway databases

ReactomeiR-GGA-2465910 MASTL Facilitates Mitotic Progression

Miscellaneous databases

PROiPR:Q5ZLY8

Gene expression databases

BgeeiENSGALG00000017370 Expressed in 11 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR006760 Endosulphine
PANTHERiPTHR10358 PTHR10358, 1 hit
PfamiView protein in Pfam
PF04667 Endosulfine, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiARP19_CHICK
AccessioniPrimary (citable) accession number: Q5ZLY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: January 23, 2007
Last modified: October 10, 2018
This is version 83 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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