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Protein

Lariat debranching enzyme

Gene

DBR1

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cleaves the 2'-5' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molecules that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
Lariat debranching enzyme (EC:3.1.-.-)
Gene namesi
Name:DBR1
ORF Names:RCJMB04_5i14
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002503601 – 536Lariat debranching enzymeAdd BLAST536

Proteomic databases

PaxDbiQ5ZLM2
PRIDEiQ5ZLM2

Expressioni

Gene expression databases

BgeeiENSGALG00000001190 Expressed in 10 organ(s), highest expression level in lung

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000001803

Structurei

3D structure databases

ProteinModelPortaliQ5ZLM2
SMRiQ5ZLM2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lariat debranching enzyme family.Curated

Phylogenomic databases

eggNOGiKOG2863 Eukaryota
ENOG410XP0F LUCA
GeneTreeiENSGT00510000047481
HOGENOMiHOG000216468
HOVERGENiHBG079917
InParanoidiQ5ZLM2
KOiK18328
OMAiGHFECPP
OrthoDBiEOG091G0AE9
PhylomeDBiQ5ZLM2
TreeFamiTF313221

Family and domain databases

Gene3Di3.60.21.10, 1 hit
InterProiView protein in InterPro
IPR004843 Calcineurin-like_PHP_ApaH
IPR007708 DBR1_C
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF05011 DBR1, 1 hit
PF00149 Metallophos, 1 hit
SMARTiView protein in SMART
SM01124 DBR1, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZLM2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVAVAGCCH GALDKMYETL ELLQRRHNVR PDLLLCCGDF QAVRNEADLR
60 70 80 90 100
CMAVPAKYRH MQTFYRYYSG EKKAPVLTVF IGGNHEASNH LQELPYGGWV
110 120 130 140 150
APNIYYLGYA GVVRFRGVRI GGISGIFKSH DYRKGHFECP PYNQQTIRSA
160 170 180 190 200
YHVRNIEVFK LKQLKHPMDI FMSHDWPQSI YHYGNKKQLL KMKSFFRQEV
210 220 230 240 250
ESNTLGSPAA SELLQHLKPN YWFSAHLHVK FAAFMQHETK SKEELPKATK
260 270 280 290 300
FLALDKCLPH RDFLQIIDIE HDPTAGDSLE YDAEWIAVLK ATNSLINVTQ
310 320 330 340 350
SSWSVPENNG LHAKWDYSAT EEAIKEVLEE LNHNLKIPCN FTLTTTCYDP
360 370 380 390 400
SKPQKNMEPV HTINPQTTEF CAQFGLTDIN DRIQQVKEEG SVRGEYEEEE
410 420 430 440 450
EEMDSSGSAE EPSEYNTDNS GLSSINPDEI MLDDEGGDED LSTCSVDPSP
460 470 480 490 500
DHPPEFSASF SDIRIMPDSM AVSSDDAMDS TNEELEKSGV NKQVEEKSLN
510 520 530
ERPLKRVGGS ENGNSGIKIK RRNQAIYAAE DEDEAK
Length:536
Mass (Da):60,777
Last modified:November 23, 2004 - v1
Checksum:i3D1D8CF2EB409FB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719712 mRNA Translation: CAG31371.1
RefSeqiNP_001026737.1, NM_001031566.1
UniGeneiGga.22334

Genome annotation databases

EnsembliENSGALT00000050471; ENSGALP00000055797; ENSGALG00000043797
GeneIDi429118
KEGGigga:429118

Similar proteinsi

Entry informationi

Entry nameiDBR1_CHICK
AccessioniPrimary (citable) accession number: Q5ZLM2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: November 23, 2004
Last modified: September 12, 2018
This is version 82 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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