UniProtKB - Q5ZLM0 (CDC73_CHICK)
Parafibromin
CDC73
Functioni
Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity).
By similarityGO - Molecular functioni
- RNA polymerase II complex binding Source: UniProtKB
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- cellular response to lipopolysaccharide Source: Ensembl
- endodermal cell fate commitment Source: UniProtKB
- histone H2B ubiquitination Source: Ensembl
- histone monoubiquitination Source: Ensembl
- mRNA polyadenylation Source: UniProtKB
- negative regulation of apoptotic process Source: Ensembl
- negative regulation of cell population proliferation Source: UniProtKB
- negative regulation of epithelial cell proliferation Source: Ensembl
- negative regulation of fibroblast proliferation Source: Ensembl
- negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
- negative regulation of myeloid cell differentiation Source: UniProtKB
- negative regulation of transcription by RNA polymerase II Source: UniProtKB
- positive regulation of cell cycle G1/S phase transition Source: UniProtKB
- positive regulation of mRNA 3'-end processing Source: UniProtKB
- positive regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
- positive regulation of Wnt signaling pathway Source: UniProtKB
- protein destabilization Source: Ensembl
- recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex Source: GO_Central
- regulation of cell growth Source: Ensembl
- stem cell population maintenance Source: UniProtKB
- transcription elongation from RNA polymerase II promoter Source: UniProtKB
Keywordsi
Biological process | Cell cycle, Transcription |
Enzyme and pathway databases
Reactomei | R-GGA-201722, Formation of the beta-catenin:TCF transactivating complex R-GGA-674695, RNA Polymerase II Pre-transcription Events R-GGA-75955, RNA Polymerase II Transcription Elongation |
Names & Taxonomyi
Protein namesi | Recommended name: ParafibrominAlternative name(s): Cell division cycle protein 73 homolog |
Gene namesi | Name:CDC73 ORF Names:RCJMB04_5j4 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus By similarity
Cytosol
- cytosol Source: Ensembl
Nucleus
- Cdc73/Paf1 complex Source: UniProtKB
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000191806 | 1 – 531 | ParafibrominAdd BLAST | 531 |
Proteomic databases
PaxDbi | Q5ZLM0 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000002469, Expressed in skeletal muscle tissue and 14 other tissues |
Interactioni
Subunit structurei
Component of the PAF1 complex, which at least consists of CDC73, PAF1, LEO1, CTR9 and RTF1.
By similarityGO - Molecular functioni
- RNA polymerase II complex binding Source: UniProtKB
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000003888 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 260 – 303 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 325 – 358 | DisorderedSequence analysisAdd BLAST | 34 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 125 – 139 | Nuclear localization signalBy similarityAdd BLAST | 15 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 325 – 340 | Polar residuesSequence analysisAdd BLAST | 16 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG3786, Eukaryota |
GeneTreei | ENSGT00390000001114 |
HOGENOMi | CLU_025849_0_1_1 |
InParanoidi | Q5ZLM0 |
OMAi | NVARWAV |
OrthoDBi | 720340at2759 |
PhylomeDBi | Q5ZLM0 |
TreeFami | TF313016 |
Family and domain databases
Gene3Di | 3.40.50.11990, 1 hit |
InterProi | View protein in InterPro IPR007852, Cdc73/Parafibromin IPR031336, CDC73_C IPR038103, CDC73_C_sf IPR032041, Cdc73_N |
PANTHERi | PTHR12466, PTHR12466, 1 hit |
Pfami | View protein in Pfam PF05179, CDC73_C, 1 hit PF16050, CDC73_N, 1 hit |
i Sequence
Sequence statusi: Complete.
10 20 30 40 50
MADVLSVLRQ YNTQKKEIVV KGDEVIFGEF SWPKNVKTNY VIWGTGKEGQ
60 70 80 90 100
PREYYTLDSI LFLLNNVHLS HPVYVRRAAT ENIPVVRRPD RKDLLAYLNG
110 120 130 140 150
ETSTSSSIDR SAPLEIGLQR STQVKRAADE ILAEAKKPRI EDEECVRLDK
160 170 180 190 200
ERLAARLEGH KEGIVQTEQI RSLSEAMSVE KIAAIKAKIM AKKRSTIKTD
210 220 230 240 250
LDDDITALKQ RSFVDAEVDV TRDIVSRERV WRTRTTILQS TGKNFAKNIF
260 270 280 290 300
AILQSVKARE EGRAPEQRPA PNTAPTDPTL RNKQPIPAAY NRYDQERFKG
310 320 330 340 350
KEETEGFKID TMGTYHGMTL KSVTEGASAR KTQTPAAQPV PRPVSQARPP
360 370 380 390 400
PNQKKGSRTP IIIIPAATTS LITMLNAKDL LQDLKFVPSD EKKKQGCQRE
410 420 430 440 450
NETLIQRRKD QMQPGGTTVS VTVPYRVVDQ PLKLMPQDWD RVVAVFVQGP
460 470 480 490 500
AWQFKGWPWL LPDGSPVDIF AKIKAFHLKY DEVRLDPNVQ KWDVTVLELS
510 520 530
YHKRHLDRPV FLRFWETLDR YMVKHKSHLR F
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719714 mRNA Translation: CAG31373.1 |
RefSeqi | NP_001026436.1, NM_001031265.1 |
Genome annotation databases
Ensembli | ENSGALT00000003897; ENSGALP00000003888; ENSGALG00000002469 |
GeneIDi | 424356 |
KEGGi | gga:424356 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719714 mRNA Translation: CAG31373.1 |
RefSeqi | NP_001026436.1, NM_001031265.1 |
3D structure databases
SMRi | Q5ZLM0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000003888 |
Proteomic databases
PaxDbi | Q5ZLM0 |
Genome annotation databases
Ensembli | ENSGALT00000003897; ENSGALP00000003888; ENSGALG00000002469 |
GeneIDi | 424356 |
KEGGi | gga:424356 |
Organism-specific databases
CTDi | 79577 |
Phylogenomic databases
eggNOGi | KOG3786, Eukaryota |
GeneTreei | ENSGT00390000001114 |
HOGENOMi | CLU_025849_0_1_1 |
InParanoidi | Q5ZLM0 |
OMAi | NVARWAV |
OrthoDBi | 720340at2759 |
PhylomeDBi | Q5ZLM0 |
TreeFami | TF313016 |
Enzyme and pathway databases
Reactomei | R-GGA-201722, Formation of the beta-catenin:TCF transactivating complex R-GGA-674695, RNA Polymerase II Pre-transcription Events R-GGA-75955, RNA Polymerase II Transcription Elongation |
Miscellaneous databases
PROi | PR:Q5ZLM0 |
Gene expression databases
Bgeei | ENSGALG00000002469, Expressed in skeletal muscle tissue and 14 other tissues |
Family and domain databases
Gene3Di | 3.40.50.11990, 1 hit |
InterProi | View protein in InterPro IPR007852, Cdc73/Parafibromin IPR031336, CDC73_C IPR038103, CDC73_C_sf IPR032041, Cdc73_N |
PANTHERi | PTHR12466, PTHR12466, 1 hit |
Pfami | View protein in Pfam PF05179, CDC73_C, 1 hit PF16050, CDC73_N, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CDC73_CHICK | |
Accessioni | Q5ZLM0Primary (citable) accession number: Q5ZLM0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | November 23, 2004 | |
Last modified: | September 29, 2021 | |
This is version 98 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families