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UniProtKB - Q5ZLL6 (MSMO1_CHICK)
Protein
Methylsterol monooxygenase 1
Gene
MSMO1
Organism
Gallus gallus (Chicken)
Status
Functioni
Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol.
By similarityCatalytic activityi
- 4,4-dimethyl-5α-cholest-7-en-3β-ol + 6 Fe(II)-[cytochrome b5] + 5 H+ + 3 O2 = 4α-carboxy-4β-methyl-5α-cholest-7-ene-3β-ol + 6 Fe(III)-[cytochrome b5] + 4 H2OBy similarityEC:1.14.18.9By similarity
Cofactori
Fe cationBy similarity
: zymosterol biosynthesis Pathwayi
This protein is involved in step 3 of the subpathway that synthesizes zymosterol from lanosterol. This subpathway is part of the pathway zymosterol biosynthesis, which is itself part of Steroid biosynthesis.View all proteins of this organism that are known to be involved in the subpathway that synthesizes zymosterol from lanosterol, the pathway zymosterol biosynthesis and in Steroid biosynthesis.
GO - Molecular functioni
- C-4 methylsterol oxidase activity Source: GO_Central
- iron ion binding Source: InterPro
- oxidoreductase activity Source: GO_Central
GO - Biological processi
- sterol biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism |
Ligand | Iron, NAD |
Enzyme and pathway databases
UniPathwayi | UPA00770;UER00756 |
Names & Taxonomyi
Protein namesi | Recommended name: Methylsterol monooxygenase 1 (EC:1.14.18.9By similarity)Alternative name(s): C-4 methylsterol oxidase |
Gene namesi | Name:MSMO1 Synonyms:SC4MOL ORF Names:RCJMB04_5j19 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane Curated; Multi-pass membrane protein Curated
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 55 – 75 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 100 – 120 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 199 – 219 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000249852 | 1 – 296 | Methylsterol monooxygenase 1Add BLAST | 296 |
Proteomic databases
PaxDbi | Q5ZLL6 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 145 – 274 | Fatty acid hydroxylaseSequence analysisAdd BLAST | 130 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 157 – 161 | Histidine box-1By similarity | 5 | |
Motifi | 170 – 174 | Histidine box-2By similarity | 5 | |
Motifi | 249 – 255 | Histidine box-3By similarity | 7 |
Domaini
The histidine box domains may contain the active site and/or be involved in metal ion binding.
Sequence similaritiesi
Belongs to the sterol desaturase family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0873, Eukaryota |
InParanoidi | Q5ZLL6 |
OrthoDBi | 1493916at2759 |
PhylomeDBi | Q5ZLL6 |
Family and domain databases
InterProi | View protein in InterPro IPR006694, Fatty_acid_hydroxylase |
Pfami | View protein in Pfam PF04116, FA_hydroxylase, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5ZLL6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVNDSVNIL NSAYLAVEYI DSFLPDNPLQ QPFKNAWNYM LDNYTKFQIA
60 70 80 90 100
TWGSLLVHEA SYFLLCVPGF IFQFIPYMQK YKIQPDKPET WEKQWKCFKT
110 120 130 140 150
LIFNHFFIQL PLICGTYYFT EYFNIPYEWE EMPRWYVLLA QCFGCAVIED
160 170 180 190 200
AWHYFLHRLL HHKRIYKYIH KVHHEFVSPF GMQAEYAHPL ETLILGAGFF
210 220 230 240 250
IGIVVFCNHV VLLWAWVICR LMETIDVHSG YDIPLNPLHL VPFYAGARFH
260 270 280 290
DFHHMNFIGN YASTFTWWDR IFGTDSQFIA YKEKEKKQQL RMKKTN
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719718 mRNA Translation: CAG31377.1 |
RefSeqi | NP_001006438.1, NM_001006438.1 |
Genome annotation databases
GeneIDi | 422423 |
KEGGi | gga:422423 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719718 mRNA Translation: CAG31377.1 |
RefSeqi | NP_001006438.1, NM_001006438.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000015550 |
Proteomic databases
PaxDbi | Q5ZLL6 |
Genome annotation databases
GeneIDi | 422423 |
KEGGi | gga:422423 |
Organism-specific databases
CTDi | 6307 |
Phylogenomic databases
eggNOGi | KOG0873, Eukaryota |
InParanoidi | Q5ZLL6 |
OrthoDBi | 1493916at2759 |
PhylomeDBi | Q5ZLL6 |
Enzyme and pathway databases
UniPathwayi | UPA00770;UER00756 |
Miscellaneous databases
PROi | PR:Q5ZLL6 |
Family and domain databases
InterProi | View protein in InterPro IPR006694, Fatty_acid_hydroxylase |
Pfami | View protein in Pfam PF04116, FA_hydroxylase, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | MSMO1_CHICK | |
Accessioni | Q5ZLL6Primary (citable) accession number: Q5ZLL6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | September 19, 2006 |
Last sequence update: | November 23, 2004 | |
Last modified: | February 23, 2022 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families