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Protein

3-hydroxyisobutyrate dehydrogenase

Gene

HIBADH

Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.UniRule annotation

Pathwayi: L-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei105NADUniRule annotation1
Binding sitei131NADUniRule annotation1
Active sitei206UniRule annotation1
Binding sitei281NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi37 – 65NADUniRule annotationAdd BLAST29
Nucleotide bindingi100 – 101NADUniRule annotation2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processBranched-chain amino acid catabolismUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-GGA-70895 Branched-chain amino acid catabolism
UniPathwayiUPA00362

Names & Taxonomyi

Protein namesi
Recommended name:
3-hydroxyisobutyrate dehydrogenaseUniRule annotation (EC:1.1.1.31UniRule annotation)
Short name:
HIBADHUniRule annotation
Gene namesi
Name:HIBADHImported
ORF Names:RCJMB04_5p10Imported
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Expressioni

Gene expression databases

BgeeiENSGALG00000011100

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000018063

Structurei

3D structure databases

SMRiQ5ZLI9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 197NAD_binding_2InterPro annotationAdd BLAST159
Domaini200 – 327NAD_binding_11InterPro annotationAdd BLAST128

Sequence similaritiesi

Belongs to the 3-hydroxyisobutyrate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0409 Eukaryota
COG2084 LUCA
GeneTreeiENSGT00530000063270
HOGENOMiHOG000219610
HOVERGENiHBG050424
KOiK00020
TreeFamiTF314043

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006115 6PGDH_NADP-bd
IPR011548 HIBADH
IPR015815 HIBADH-related
IPR036291 NAD(P)-bd_dom_sf
IPR029154 NADP-bd
PfamiView protein in Pfam
PF14833 NAD_binding_11, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000103 HIBADH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01692 HIBADH, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZLI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAAVVLGGP AGWWRWHRRV RAARAAMVCS RAMASKTPVG FIGLGNMGNP
60 70 80 90 100
MAKNLIKHGY PVIAYDVFPE ACKEFQDLGA QVTDSPADVA ERADRIITML
110 120 130 140 150
PSSPNAIEVY TGANGILKKV KKGSLLIDSS TIDPSVSKEL AKAVEKMGAV
160 170 180 190 200
FMDAPVSGGV GAARAGNLTF MVGGMEQEFD AAKELLICMG SNVVYCGEVG
210 220 230 240 250
TGQAAKICNN MLLAISMIGT AETMNLGIRL GLDPKLLAKI LNMSSGRCWS
260 270 280 290 300
SDTYNPVPGV MEGVPSANNY QGGFGTTLMA KDLGLAQISA TNTKTPVPLG
310 320 330
SQAHQIYRMM CAKGYALKDF SAVFQFLREE ESL
Length:333
Mass (Da):35,284
Last modified:November 23, 2004 - v1
Checksum:iA08CCA2D3B42A5C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AADN04000091 Genomic DNA No translation available.
AC163702 Genomic DNA No translation available.
AJ719745 mRNA Translation: CAG31404.1
RefSeqiNP_001006362.1, NM_001006362.2
UniGeneiGga.22571

Genome annotation databases

EnsembliENSGALT00000061433; ENSGALP00000057750; ENSGALG00000033207
GeneIDi420632
KEGGigga:420632

Similar proteinsi

Entry informationi

Entry nameiQ5ZLI9_CHICK
AccessioniPrimary (citable) accession number: Q5ZLI9
Entry historyiIntegrated into UniProtKB/TrEMBL: November 23, 2004
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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