Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-18

Gene

RAB18

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in apical endocytosis/recycling. May be implicated in transport between the plasma membrane and early endosomes. Plays a key role in eye and brain development and neurodegeneration (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 22GTPBy similarity8
Nucleotide bindingi63 – 67GTPBy similarity5
Nucleotide bindingi122 – 125GTPBy similarity4

GO - Molecular functioni

  • GDP binding Source: UniProtKB
  • GTPase activity Source: GO_Central
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-GGA-6798695 Neutrophil degranulation
R-GGA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-GGA-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-18
Gene namesi
Name:RAB18
ORF Names:RCJMB04_6g4
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001211971 – 203Ras-related protein Rab-18Add BLAST203
PropeptideiPRO_0000370765204 – 206Removed in mature formSequence analysis3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi199S-palmitoyl cysteineSequence analysis1
Modified residuei203Cysteine methyl esterSequence analysis1
Lipidationi203S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Palmitate, Prenylation

Proteomic databases

PaxDbiQ5ZLG1
PRIDEiQ5ZLG1

Expressioni

Gene expression databases

BgeeiENSGALG00000007435 Expressed in 11 organ(s), highest expression level in female gonad

Interactioni

Protein-protein interaction databases

BioGridi681433, 1 interactor
IntActiQ5ZLG1, 1 interactor
STRINGi9031.ENSGALP00000012019

Structurei

3D structure databases

ProteinModelPortaliQ5ZLG1
SMRiQ5ZLG1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi37 – 45Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ5ZLG1
KOiK07910
OMAiMQSTVGM
OrthoDBiEOG091G0MOO
PhylomeDBiQ5ZLG1
TreeFamiTF313448

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q5ZLG1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDEDVLTTLK ILIIGESGVG KSSLLLRFTD DTFDPELAAT IGVDFKVKTI
60 70 80 90 100
SVDGNKAKLA IWDTAGQERF RTLTPSYYRG AQGVILVYDV TRRDTFVKLD
110 120 130 140 150
NWLNELETYC TRNDIVKMLV GNKIDKENRE VDRNEGLKFA RKHSMLFIEA
160 170 180 190 200
SAKTCDGVQC AFEELVEKII QTPGLWESES QNKGVKLSNK EEGHGGGACG

GYCSML
Length:206
Mass (Da):22,954
Last modified:November 23, 2004 - v1
Checksum:iC312C672E72FDA22
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719773 mRNA Translation: CAG31432.1
RefSeqiNP_001006355.1, NM_001006355.1
UniGeneiGga.42447

Genome annotation databases

EnsembliENSGALT00000012033; ENSGALP00000012019; ENSGALG00000007435
ENSGALT00000085826; ENSGALP00000062764; ENSGALG00000007435
GeneIDi420483
KEGGigga:420483

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719773 mRNA Translation: CAG31432.1
RefSeqiNP_001006355.1, NM_001006355.1
UniGeneiGga.42447

3D structure databases

ProteinModelPortaliQ5ZLG1
SMRiQ5ZLG1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi681433, 1 interactor
IntActiQ5ZLG1, 1 interactor
STRINGi9031.ENSGALP00000012019

Proteomic databases

PaxDbiQ5ZLG1
PRIDEiQ5ZLG1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000012033; ENSGALP00000012019; ENSGALG00000007435
ENSGALT00000085826; ENSGALP00000062764; ENSGALG00000007435
GeneIDi420483
KEGGigga:420483

Organism-specific databases

CTDi22931

Phylogenomic databases

eggNOGiKOG0080 Eukaryota
ENOG410XPD0 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ5ZLG1
KOiK07910
OMAiMQSTVGM
OrthoDBiEOG091G0MOO
PhylomeDBiQ5ZLG1
TreeFamiTF313448

Enzyme and pathway databases

ReactomeiR-GGA-6798695 Neutrophil degranulation
R-GGA-6811436 COPI-independent Golgi-to-ER retrograde traffic
R-GGA-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

PROiPR:Q5ZLG1

Gene expression databases

BgeeiENSGALG00000007435 Expressed in 11 organ(s), highest expression level in female gonad

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR025662 Sigma_54_int_dom_ATP-bd_1
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB18_CHICK
AccessioniPrimary (citable) accession number: Q5ZLG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: November 23, 2004
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again