UniProtKB - Q5ZLG0 (AACS_CHICK)
Protein
Acetoacetyl-CoA synthetase
Gene
AACS
Organism
Gallus gallus (Chicken)
Status
Functioni
Activates acetoacetate to acetoacetyl-CoA. May be involved in utilizing ketone body for the fatty acid-synthesis during adipose tissue development (By similarity).By similarity
Catalytic activityi
- EC:6.2.1.16
GO - Molecular functioni
- acetoacetate-CoA ligase activity Source: GO_Central
- ATP binding Source: UniProtKB-KW
GO - Biological processi
- fatty acid metabolic process Source: UniProtKB-KW
- positive regulation of insulin secretion Source: GO_Central
Keywordsi
Molecular function | Ligase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:AACS ORF Names:RCJMB04_6g9 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Keywords - Cellular componenti
CytoplasmPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000315788 | 1 – 667 | Acetoacetyl-CoA synthetaseAdd BLAST | 667 |
Proteomic databases
PaxDbi | Q5ZLG0 |
PRIDEi | Q5ZLG0 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000002899, Expressed in brain and 14 other tissues |
Family & Domainsi
Sequence similaritiesi
Belongs to the ATP-dependent AMP-binding enzyme family.Curated
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
HOGENOMi | CLU_1418071_0_0_1 |
InParanoidi | Q5ZLG0 |
OrthoDBi | 899666at2759 |
PhylomeDBi | Q5ZLG0 |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR005914, Acac_CoA_synth IPR032387, ACAS_N IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit |
TIGRFAMsi | TIGR01217, ac_ac_CoA_syn, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5ZLG0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSREPEIMES QVMWEPDSKR NTHMDRFRAA VAGSCGLRLA NYNDLYQWSV
60 70 80 90 100
ESFADFWAEF WKYSNIVCSR LYDEVVDTSK SIADVPEWFK GSRLNYAENL
110 120 130 140 150
LKHKDNDKIA LYAAKEGKEE ILKVTFEELR QAVALYAAAM RKMGVKIGDR
160 170 180 190 200
VVGYLPNSIH AVEAMLAAAS IGAIWSSTSP DFGINGVLDR FSQIQPKLIF
210 220 230 240 250
SVEAVVYNGK EHNHLEKLLS VVKGLPDLKK VVVIPYVSSR ETIDISKIPN
260 270 280 290 300
SVFLEDFLAT GKGDQAPQLE FEQLPFSHPL FIMYSSGTTG APKCMVHSAG
310 320 330 340 350
GTLIQHLKEH ILHGNMSSND IIMYYTTTGW MMWNWLVTAL ATGASVVLYD
360 370 380 390 400
GSPLVPSPNV LWDLIDRLGI TILGTGAKWL AVLEEKNLKP CETHNLQTLH
410 420 430 440 450
TILSTGSPLK SQSYEYVYKH IKSSVLLGSI SGGTDIISCF MGQNVTIPVY
460 470 480 490 500
KGEIQARNLG MAVEAWNDEG KPVWGESGEL VCTKPIPCQP THFWNDENGS
510 520 530 540 550
KYRKAYFSKF PGVWAHGDYC KINPKTGGIV MLGRSDGTLN PNGVRFGSSE
560 570 580 590 600
IYNIVEAFEE VSDSLCVPQY NKDGEERVIL FLKMASNHAF SEDLVKRIRD
610 620 630 640 650
AIRVALSARH VPSLILETKG IPYTINGKKV EVAVKQIIAG KEVEQRGAFS
660
NPETLDLYQN IPELQNF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719774 mRNA Translation: CAG31433.1 |
RefSeqi | NP_001006184.1, NM_001006184.1 |
Genome annotation databases
GeneIDi | 416811 |
KEGGi | gga:416811 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719774 mRNA Translation: CAG31433.1 |
RefSeqi | NP_001006184.1, NM_001006184.1 |
3D structure databases
SMRi | Q5ZLG0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000004568 |
Proteomic databases
PaxDbi | Q5ZLG0 |
PRIDEi | Q5ZLG0 |
Genome annotation databases
GeneIDi | 416811 |
KEGGi | gga:416811 |
Organism-specific databases
CTDi | 65985 |
Phylogenomic databases
eggNOGi | KOG1175, Eukaryota |
HOGENOMi | CLU_1418071_0_0_1 |
InParanoidi | Q5ZLG0 |
OrthoDBi | 899666at2759 |
PhylomeDBi | Q5ZLG0 |
Miscellaneous databases
PROi | PR:Q5ZLG0 |
Gene expression databases
Bgeei | ENSGALG00000002899, Expressed in brain and 14 other tissues |
Family and domain databases
Gene3Di | 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR005914, Acac_CoA_synth IPR032387, ACAS_N IPR020845, AMP-binding_CS IPR000873, AMP-dep_Synth/Lig IPR042099, AMP-dep_Synthh-like_sf |
Pfami | View protein in Pfam PF16177, ACAS_N, 1 hit PF00501, AMP-binding, 1 hit |
TIGRFAMsi | TIGR01217, ac_ac_CoA_syn, 1 hit |
PROSITEi | View protein in PROSITE PS00455, AMP_BINDING, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | AACS_CHICK | |
Accessioni | Q5ZLG0Primary (citable) accession number: Q5ZLG0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 15, 2008 |
Last sequence update: | November 23, 2004 | |
Last modified: | December 2, 2020 | |
This is version 92 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families