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Protein

Integrator complex subunit 7

Gene

INTS7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. May play a role in DNA damage response (DDR) signaling during the S phase.By similarity

GO - Biological processi

Keywordsi

Biological processDNA damage

Names & Taxonomyi

Protein namesi
Recommended name:
Integrator complex subunit 7
Short name:
Int7
Gene namesi
Name:INTS7
ORF Names:RCJMB04_7c6
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002595511 – 961Integrator complex subunit 7Add BLAST961

Proteomic databases

PaxDbiQ5ZL91
PRIDEiQ5ZL91

Interactioni

Subunit structurei

Belongs to the multiprotein complex Integrator.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000015986

Structurei

3D structure databases

ProteinModelPortaliQ5ZL91
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi936 – 954Gln-richAdd BLAST19

Sequence similaritiesi

Belongs to the Integrator subunit 7 family.Curated

Phylogenomic databases

eggNOGiKOG1988 Eukaryota
ENOG410XSMR LUCA
HOGENOMiHOG000063719
HOVERGENiHBG079489
InParanoidiQ5ZL91
KOiK13144
PhylomeDBiQ5ZL91

Family and domain databases

InterProiView protein in InterPro
IPR016024 ARM-type_fold
IPR033060 INTS7
PANTHERiPTHR13322 PTHR13322, 1 hit
SUPFAMiSSF48371 SSF48371, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.iShow all

Q5ZL91-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGGKSFLA DAGYGEQELD ANSALMELDK GLRSGKLGEQ CEAVVRFPRL
60 70 80 90 100
FQKYPFPILI NSAFLKLADV FRVGNNFLRL CVLKVTQQSE KHLEKILNVD
110 120 130 140 150
EFVKRVFSVI HSNDPVARAI TLRMLGSMAS IIPERKNAHH SIRQSLDSHD
160 170 180 190 200
NVEVEAAIFA AANFSAQSKD FAAGICNKIS EMIQGLATPV DLKLKLIPIL
210 220 230 240 250
QHMHHDASLA SSSRQLLQQL VTSYPSTKMV IVTLHTFTLL AASSLVDIPK
260 270 280 290 300
QVQLLLQYLK NDPRKAVKRL AIQDLKLLAN KIPHTWSREN IQALCESALH
310 320 330 340 350
TPYDSLKLGM LSVLSTLSGT IAIKQYFSSA PGTAATTARS FDLVKLAQEC
360 370 380 390 400
CYHNNRGIAA HGVRILTNIS ASCQEKDLLP LEQDAVFGLE SLLVLCSQDD
410 420 430 440 450
SPGAQATLKI TLTCMVKLVK CRPHLSQSVV ESLLTQLHSA QDAARILMCH
460 470 480 490 500
CLAAIAMQLP VLADGMLGDL MELYKVIGRS TTDKKQELLV SLATVIFVSS
510 520 530 540 550
QKALSPEIKT VIKQQLENAS NGWTAYRIAR QASRMGNHDM ARELYQSLLT
560 570 580 590 600
QVASEHFYFW LNSLKEFSHA EQCLTGLQED NYSSALSCIA EALKSYHKGI
610 620 630 640 650
ASLTAASTPL NPLSFQCGFV KLRIDLLQAF SQLICTCNSL KTSPPPAIAT
660 670 680 690 700
TIAMTSGNDL QRCGRISNQM KLSMEEFRNL AVRYGDLYQS SFDADSATLR
710 720 730 740 750
NVELQQQSCL LISHAIEALI LDPESANFQE YSSNGAAHVE SEYERRMMSV
760 770 780 790 800
FNHVLEEVES LNRKYAPVSY LHTACLCSAV IALLKVPLSF QRYFFQKLQS
810 820 830 840 850
TSIKLALSPS PRNPAEPIAV QNNQQLALKV EGVVQHGSKP GLFRKIQSVC
860 870 880 890 900
LNVSSVLQSK SGQDYKIPID NMTNEMEQRV EPHNDYFSTQ FLLNFVILDT
910 920 930 940 950
HNITVESSVI DSNGIVWKTG PKTTIFVKSL EDPYSQQVRL QQQQGQPPSQ
960
QQQQRTAYSR F
Length:961
Mass (Da):106,531
Last modified:November 23, 2004 - v1
Checksum:iF8E44B51E2083963
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1NPA4F1NPA4_CHICK
Integrator complex subunit 7
INTS7
961Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719843 mRNA Translation: CAG31502.1
RefSeqiNP_001006399.1, NM_001006399.1
UniGeneiGga.22243

Genome annotation databases

GeneIDi421374
KEGGigga:421374

Similar proteinsi

Entry informationi

Entry nameiINT7_CHICK
AccessioniPrimary (citable) accession number: Q5ZL91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: November 23, 2004
Last modified: May 23, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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