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UniProtKB - Q5ZL84 (SGMR1_CHICK)
Protein
Sigma non-opioid intracellular receptor 1
Gene
SIGMAR1
Organism
Gallus gallus (Chicken)
Status
Functioni
May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity).
By similarityMiscellaneous
Sigma receptors are classified into two subtypes (Sigma-1 and Sigma-2) based on their different pharmacological profile.By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 125 | Important for ligand bindingBy similarity | 1 | |
Sitei | 171 | Important for ligand bindingBy similarity | 1 |
GO - Biological processi
- lipid transport Source: UniProtKB-KW
- regulation of neuron apoptotic process Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Lipid transport, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: Sigma non-opioid intracellular receptor 1Alternative name(s): Sigma 1-type opioid receptor Short name: Sigma1-receptor Short name: Sigma1R |
Gene namesi | Name:SIGMAR1 Synonyms:OPRS1 ORF Names:RCJMB04_7e2 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus inner membrane By similarity
- Nucleus outer membrane By similarity
- Nucleus envelope By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity
Other locations
- Cytoplasmic vesicle By similarity
- Membrane By similarity; Single-pass membrane protein By similarity
Note: During interphase, detected at the inner and outer nuclear membrane and the endoplasmic reticulum. Detected on cytoplasmic vesicles during mitosis (By similarity). Targeted to lipid droplets, cholesterol and galactosylceramide-enriched domains of the endoplasmic reticulum (By similarity).By similarity
Endoplasmic reticulum
- endoplasmic reticulum Source: GO_Central
- endoplasmic reticulum membrane Source: UniProtKB-SubCell
Nucleus
- nuclear inner membrane Source: UniProtKB-SubCell
- nuclear outer membrane Source: UniProtKB-SubCell
Other locations
- cytoplasmic vesicle Source: UniProtKB-KW
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 7 | LumenalBy similarity | 7 | |
Transmembranei | 8 – 29 | HelicalBy similarityAdd BLAST | 22 | |
Topological domaini | 30 – 222 | CytoplasmicBy similarityAdd BLAST | 193 |
Keywords - Cellular componenti
Cytoplasmic vesicle, Endoplasmic reticulum, Membrane, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000268657 | 1 – 222 | Sigma non-opioid intracellular receptor 1Add BLAST | 222 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000028996, Expressed in liver and 12 other tissues |
ExpressionAtlasi | Q5ZL84, baseline and differential |
Interactioni
Subunit structurei
Homotrimer (By similarity).
By similarityProtein-protein interaction databases
STRINGi | 9031.ENSGALP00000042968 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 98 – 105 | Important for ligand-bindingBy similarity | 8 | |
Regioni | 176 – 222 | C-terminal hydrophobic regionCuratedAdd BLAST | 47 |
Domaini
The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.By similarity
Sequence similaritiesi
Belongs to the ERG2 family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG4143, Eukaryota |
GeneTreei | ENSGT00390000012082 |
HOGENOMi | CLU_085469_0_0_1 |
InParanoidi | Q5ZL84 |
OMAi | LWATTRI |
OrthoDBi | 1285317at2759 |
PhylomeDBi | Q5ZL84 |
Family and domain databases
InterProi | View protein in InterPro IPR006716, ERG2_sigma1_rcpt-like |
PANTHERi | PTHR10868, PTHR10868, 1 hit |
Pfami | View protein in Pfam PF04622, ERG2_Sigma1R, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q5ZL84-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGVAGPWVLR VGLGLGAFAL LLQGLRGWLA CKRYEFQPAE IAELARHHAG
60 70 80 90 100
LDHELAFSKI IVELRKKHPG HILPDEDLQW VFVNAGGWMG SMCLLHASLT
110 120 130 140 150
EYVLLFGTAI DTGGHSGRYW AEIYDTIISG TFRQWKEGTT RSEIYYPGDT
160 170 180 190 200
IVHQAGEATS VQWSAGTWMV EYGRGFVPST LAFALADTLF STQDFITLFY
210 220
TLRAYTKGLL LEASAFFSTL GC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5PVF0 | A0A1D5PVF0_CHICK | Sigma non-opioid intracellular rece... | SIGMAR1 | 242 | Annotation score: | ||
A0A1D5P285 | A0A1D5P285_CHICK | Sigma non-opioid intracellular rece... | SIGMAR1 | 164 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719850 mRNA Translation: CAG31509.1 |
RefSeqi | NP_001257486.3, NM_001270557.3 |
Genome annotation databases
Ensembli | ENSGALT00000046016; ENSGALP00000042968; ENSGALG00000028996 |
GeneIDi | 100859748 |
KEGGi | gga:100859748 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719850 mRNA Translation: CAG31509.1 |
RefSeqi | NP_001257486.3, NM_001270557.3 |
3D structure databases
AlphaFoldDBi | Q5ZL84 |
SMRi | Q5ZL84 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000042968 |
Genome annotation databases
Ensembli | ENSGALT00000046016; ENSGALP00000042968; ENSGALG00000028996 |
GeneIDi | 100859748 |
KEGGi | gga:100859748 |
Organism-specific databases
CTDi | 10280 |
Phylogenomic databases
eggNOGi | KOG4143, Eukaryota |
GeneTreei | ENSGT00390000012082 |
HOGENOMi | CLU_085469_0_0_1 |
InParanoidi | Q5ZL84 |
OMAi | LWATTRI |
OrthoDBi | 1285317at2759 |
PhylomeDBi | Q5ZL84 |
Miscellaneous databases
PROi | PR:Q5ZL84 |
Gene expression databases
Bgeei | ENSGALG00000028996, Expressed in liver and 12 other tissues |
ExpressionAtlasi | Q5ZL84, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR006716, ERG2_sigma1_rcpt-like |
PANTHERi | PTHR10868, PTHR10868, 1 hit |
Pfami | View protein in Pfam PF04622, ERG2_Sigma1R, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SGMR1_CHICK | |
Accessioni | Q5ZL84Primary (citable) accession number: Q5ZL84 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 12, 2006 |
Last sequence update: | November 23, 2004 | |
Last modified: | May 25, 2022 | |
This is version 80 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families