UniProtKB - Q5ZL74 (VAMP7_CHICK)
Vesicle-associated membrane protein 7
VAMP7
Functioni
Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for focal exocytosis of late endocytic vesicles during phagosome formation (By similarity).
By similarityGO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
GO - Biological processi
- calcium-ion regulated exocytosis Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- endosome to lysosome transport Source: UniProtKB
- eosinophil degranulation Source: UniProtKB
- exocytosis Source: GO_Central
- natural killer cell degranulation Source: Ensembl
- neutrophil degranulation Source: UniProtKB
- phagocytosis, engulfment Source: UniProtKB
- positive regulation of histamine secretion by mast cell Source: Ensembl
- protein transport Source: UniProtKB-KW
- vesicle fusion Source: UniProtKB
- vesicle-mediated transport Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-GGA-432720, Lysosome Vesicle Biogenesis R-GGA-432722, Golgi Associated Vesicle Biogenesis R-GGA-8856825, Cargo recognition for clathrin-mediated endocytosis R-GGA-8856828, Clathrin-mediated endocytosis |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle-associated membrane protein 7Alternative name(s): Synaptobrevin-like protein 1 |
Gene namesi | Name:VAMP7By similarity Synonyms:SYBL1By similarity ORF Names:RCJMB04_7f19 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Endosome
- Late endosome membrane Sequence analysisBy similarity; Single-pass type IV membrane protein Sequence analysisBy similarity
Golgi apparatus
- trans-Golgi network membrane Sequence analysisBy similarity; Single-pass type IV membrane protein Sequence analysisBy similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane Sequence analysisBy similarity; Single-pass type IV membrane protein Sequence analysisBy similarity
Lysosome
- Lysosome membrane Sequence analysisBy similarity; Single-pass type IV membrane protein Sequence analysisBy similarity
Other locations
- secretory vesicle membrane Sequence analysisBy similarity; Single-pass type IV membrane protein Sequence analysisBy similarity
- phagosome membrane Sequence analysisBy similarity; Single-pass type IV membrane protein Sequence analysisBy similarity
- synaptosome By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Endosome
- late endosome membrane Source: UniProtKB
Golgi apparatus
- trans-Golgi network Source: Ensembl
Lysosome
- azurophil granule membrane Source: Ensembl
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
- lamellipodium Source: Ensembl
- neuron projection Source: UniProtKB
- phagocytic vesicle Source: UniProtKB
- phagocytic vesicle membrane Source: UniProtKB-SubCell
- platelet alpha granule Source: Ensembl
- pseudopodium Source: Ensembl
- SNARE complex Source: UniProtKB
- synapse Source: UniProtKB-SubCell
- transport vesicle membrane Source: UniProtKB-SubCell
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 188 | CytoplasmicSequence analysisBy similarityAdd BLAST | 187 | |
Transmembranei | 189 – 209 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 220 | VesicularSequence analysisBy similarityAdd BLAST | 11 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Synapse, SynaptosomePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000319995 | 2 – 220 | Vesicle-associated membrane protein 7By similarityAdd BLAST | 219 |
Proteomic databases
PaxDbi | Q5ZL74 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000007476, Expressed in spermatid and 14 other tissues |
Interactioni
GO - Molecular functioni
- SNARE binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000031702 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 110 | LonginPROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 125 – 185 | v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0859, Eukaryota |
GeneTreei | ENSGT00510000047733 |
HOGENOMi | CLU_064620_1_1_1 |
InParanoidi | Q5ZL74 |
OMAi | NTKLMIM |
OrthoDBi | 1211929at2759 |
PhylomeDBi | Q5ZL74 |
Family and domain databases
CDDi | cd14824, Longin, 1 hit |
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR010908, Longin_dom IPR001388, Synaptobrevin IPR042855, V_SNARE_CC |
Pfami | View protein in Pfam PF13774, Longin, 1 hit PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
SMARTi | View protein in SMART SM01270, Longin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS50859, LONGIN, 1 hit PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY
60 70 80 90 100
LFHYICQDRI IYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY
110 120 130 140 150
AMNSEFSSVL AAQLKYHSES KGTDQVAETQ AQVDELKGIM VRNIDLVAQR
160 170 180 190 200
GEKLELLIDK TENLVDSSVT FKTTSRNLAR AMCMKNLKLT IIIIIVSIVI
210 220
IYIIVSAACG GLAWPSCVQK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719860 mRNA Translation: CAG31519.1 |
RefSeqi | NP_001026292.1, NM_001031121.1 XP_015133771.1, XM_015278285.1 XP_015133772.1, XM_015278286.1 XP_015133773.1, XM_015278287.1 XP_015133774.1, XM_015278288.1 XP_015133775.1, XM_015278289.1 |
Genome annotation databases
Ensembli | ENSGALT00000032338; ENSGALP00000031702; ENSGALG00000007476 ENSGALT00000087818; ENSGALP00000059872; ENSGALG00000007476 |
GeneIDi | 422297 |
KEGGi | gga:422297 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719860 mRNA Translation: CAG31519.1 |
RefSeqi | NP_001026292.1, NM_001031121.1 XP_015133771.1, XM_015278285.1 XP_015133772.1, XM_015278286.1 XP_015133773.1, XM_015278287.1 XP_015133774.1, XM_015278288.1 XP_015133775.1, XM_015278289.1 |
3D structure databases
AlphaFoldDBi | Q5ZL74 |
BMRBi | Q5ZL74 |
SMRi | Q5ZL74 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000031702 |
Proteomic databases
PaxDbi | Q5ZL74 |
Genome annotation databases
Ensembli | ENSGALT00000032338; ENSGALP00000031702; ENSGALG00000007476 ENSGALT00000087818; ENSGALP00000059872; ENSGALG00000007476 |
GeneIDi | 422297 |
KEGGi | gga:422297 |
Organism-specific databases
CTDi | 6845 |
Phylogenomic databases
eggNOGi | KOG0859, Eukaryota |
GeneTreei | ENSGT00510000047733 |
HOGENOMi | CLU_064620_1_1_1 |
InParanoidi | Q5ZL74 |
OMAi | NTKLMIM |
OrthoDBi | 1211929at2759 |
PhylomeDBi | Q5ZL74 |
Enzyme and pathway databases
Reactomei | R-GGA-432720, Lysosome Vesicle Biogenesis R-GGA-432722, Golgi Associated Vesicle Biogenesis R-GGA-8856825, Cargo recognition for clathrin-mediated endocytosis R-GGA-8856828, Clathrin-mediated endocytosis |
Miscellaneous databases
PROi | PR:Q5ZL74 |
Gene expression databases
Bgeei | ENSGALG00000007476, Expressed in spermatid and 14 other tissues |
Family and domain databases
CDDi | cd14824, Longin, 1 hit |
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR010908, Longin_dom IPR001388, Synaptobrevin IPR042855, V_SNARE_CC |
Pfami | View protein in Pfam PF13774, Longin, 1 hit PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
SMARTi | View protein in SMART SM01270, Longin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS50859, LONGIN, 1 hit PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | VAMP7_CHICK | |
Accessioni | Q5ZL74Primary (citable) accession number: Q5ZL74 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 26, 2008 |
Last sequence update: | November 23, 2004 | |
Last modified: | May 25, 2022 | |
This is version 112 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families