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Protein

Kinesin-like protein KIF2A

Gene

KIF2A

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi313 – 320ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Motor protein
Biological processCell cycle, Cell division, Differentiation, Mitosis, Neurogenesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Kinesin-like protein KIF2A
Gene namesi
Name:KIF2ABy similarity
ORF Names:RCJMB04_9a7
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003062741 – 706Kinesin-like protein KIF2AAdd BLAST706

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ5ZKV8

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023720

Structurei

3D structure databases

ProteinModelPortaliQ5ZKV8
SMRiQ5ZKV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 553Kinesin motorPROSITE-ProRule annotationAdd BLAST331

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili154 – 187Sequence analysisAdd BLAST34
Coiled coili662 – 699Sequence analysisAdd BLAST38

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0246 Eukaryota
COG5059 LUCA
HOGENOMiHOG000231329
HOVERGENiHBG003875
InParanoidiQ5ZKV8
KOiK10393
PhylomeDBiQ5ZKV8

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZKV8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAANFGKIQ IGIYVEIKRS DGRIHQAMVT SLNEDNESVT VEWIENGDTK
60 70 80 90 100
GKEIDLESIF SLNPDLAPDE DIEPSPETQP LPAPSAKVNK IVKGRRTVAP
110 120 130 140 150
VKNDTPARDN RVASSARARP TQLPEQSSSS QQNGTVSGIS PVQAAKKEFG
160 170 180 190 200
PPSRRKSNCV KEVEKLQEKR EKRRLQQQEL REKRAQDVDA TNPNYEIMCM
210 220 230 240 250
IRDFRGNLDY RPLTTADPID EHRICVCVRK RPLNRKETLM KDLDVITIPS
260 270 280 290 300
KDVVMVHEPK QKVDLTRYLE NQTFRFDYAF DETAPNEMVY RFTARPLVET
310 320 330 340 350
IFERGMATCF AYGQTGSGKT HTMGGDFSGK NQDCSKGIYA LAARDVFLML
360 370 380 390 400
KKPNYKKLEL QVYATFFEIY SGKVFDLLNR KTKLRVLEDG KQQVQVVGLQ
410 420 430 440 450
EREVKCVEDV LKLIEIGNSC RTSGQTSANA HSSRSHAVFQ IILRRKGKLH
460 470 480 490 500
GKFSLIDLAG NERGADTSSA DRQTRLEGAE INKSLLALKE CIRALGRNKP
510 520 530 540 550
HTPFRASKLT QVLRDSFIGE NSRTCMIATI SPGMASCENT LNTLRYANRV
560 570 580 590 600
KELTIDPSAA GDIRPIIHHT PSQIDDLDTQ WGVGSSPQRD DLKLLCEQNE
610 620 630 640 650
EEVSPQLFTF HEAVSQMVEM EEQVVEDHRT VFQESIRWLE DEKALLEMTE
660 670 680 690 700
EVDYDVDSYA TQLEAILDQK IDILTELRDK VKSFRAALQE EEQASKQINP

KRPRAV
Length:706
Mass (Da):79,864
Last modified:October 2, 2007 - v2
Checksum:i6C5CA4DAE3DA1EC8
GO

Sequence cautioni

The sequence CAG31635 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719976 mRNA Translation: CAG31635.1 Different initiation.
RefSeqiNP_001034401.2, NM_001039312.2
UniGeneiGga.2067

Genome annotation databases

GeneIDi427156
KEGGigga:427156

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ719976 mRNA Translation: CAG31635.1 Different initiation.
RefSeqiNP_001034401.2, NM_001039312.2
UniGeneiGga.2067

3D structure databases

ProteinModelPortaliQ5ZKV8
SMRiQ5ZKV8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000023720

Proteomic databases

PaxDbiQ5ZKV8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi427156
KEGGigga:427156

Organism-specific databases

CTDi3796

Phylogenomic databases

eggNOGiKOG0246 Eukaryota
COG5059 LUCA
HOGENOMiHOG000231329
HOVERGENiHBG003875
InParanoidiQ5ZKV8
KOiK10393
PhylomeDBiQ5ZKV8

Miscellaneous databases

PROiPR:Q5ZKV8

Family and domain databases

Gene3Di3.40.850.10, 1 hit
InterProiView protein in InterPro
IPR027640 Kinesin-like_fam
IPR019821 Kinesin_motor_CS
IPR001752 Kinesin_motor_dom
IPR036961 Kinesin_motor_dom_sf
IPR027417 P-loop_NTPase
PANTHERiPTHR24115 PTHR24115, 1 hit
PfamiView protein in Pfam
PF00225 Kinesin, 1 hit
PRINTSiPR00380 KINESINHEAVY
SMARTiView protein in SMART
SM00129 KISc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00411 KINESIN_MOTOR_1, 1 hit
PS50067 KINESIN_MOTOR_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKIF2A_CHICK
AccessioniPrimary (citable) accession number: Q5ZKV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: October 25, 2017
This is version 91 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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