UniProtKB - Q5ZKU5 (RAB14_CHICK)
Protein
Ras-related protein Rab-14
Gene
RAB14
Organism
Gallus gallus (Chicken)
Status
Functioni
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 25 | GTPBy similarity | 8 | |
Nucleotide bindingi | 66 – 70 | GTPBy similarity | 5 | |
Nucleotide bindingi | 124 – 127 | GTPBy similarity | 4 |
GO - Molecular functioni
- GDP binding Source: Ensembl
- GTPase activity Source: GO_Central
- GTP binding Source: UniProtKB-KW
- myosin V binding Source: Ensembl
GO - Biological processi
- defense response to bacterium Source: InterPro
- endocytic recycling Source: Ensembl
- fibroblast growth factor receptor signaling pathway Source: UniProtKB
- Golgi to endosome transport Source: UniProtKB
- intracellular protein transport Source: GO_Central
- phagolysosome assembly involved in apoptotic cell clearance Source: GO_Central
- regulation of embryonic development Source: UniProtKB
- regulation of protein localization Source: Ensembl
Keywordsi
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-GGA-6798695, Neutrophil degranulation R-GGA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-14 |
Gene namesi | Name:RAB14 ORF Names:RCJMB04_9b24 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
- trans-Golgi network membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
Endosome
- Recycling endosome By similarity
- Early endosome membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
Other locations
- phagosome By similarity
Cytosol
- cytosol Source: GOC
Endosome
- early endosome Source: GO_Central
- early endosome membrane Source: UniProtKB-SubCell
- recycling endosome Source: UniProtKB-SubCell
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
- trans-Golgi network Source: InterPro
Other locations
- endomembrane system Source: GO_Central
- phagocytic vesicle Source: GO_Central
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000260529 | 2 – 215 | Ras-related protein Rab-14Add BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Lipidationi | 213 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 215 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, PrenylationProteomic databases
PaxDbi | Q5ZKU5 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000001474, Expressed in colon and 13 other tissues |
Interactioni
GO - Molecular functioni
- myosin V binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000002234 |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 40 – 48 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0097, Eukaryota |
GeneTreei | ENSGT00940000155178 |
HOGENOMi | CLU_041217_23_1_1 |
InParanoidi | Q5ZKU5 |
OMAi | QRDVTFE |
OrthoDBi | 1146851at2759 |
PhylomeDBi | Q5ZKU5 |
TreeFami | TF300032 |
Family and domain databases
CDDi | cd04122, Rab14, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030702, Rab14 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
PANTHERi | PTHR24073:SF1098, PTHR24073:SF1098, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q5ZKU5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719989 mRNA Translation: CAG31648.1 |
RefSeqi | NP_001012814.1, NM_001012796.1 |
Genome annotation databases
Ensembli | ENSGALT00000002236; ENSGALP00000002234; ENSGALG00000001474 |
GeneIDi | 417119 |
KEGGi | gga:417119 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ719989 mRNA Translation: CAG31648.1 |
RefSeqi | NP_001012814.1, NM_001012796.1 |
3D structure databases
SMRi | Q5ZKU5 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000002234 |
Proteomic databases
PaxDbi | Q5ZKU5 |
Genome annotation databases
Ensembli | ENSGALT00000002236; ENSGALP00000002234; ENSGALG00000001474 |
GeneIDi | 417119 |
KEGGi | gga:417119 |
Organism-specific databases
CTDi | 51552 |
Phylogenomic databases
eggNOGi | KOG0097, Eukaryota |
GeneTreei | ENSGT00940000155178 |
HOGENOMi | CLU_041217_23_1_1 |
InParanoidi | Q5ZKU5 |
OMAi | QRDVTFE |
OrthoDBi | 1146851at2759 |
PhylomeDBi | Q5ZKU5 |
TreeFami | TF300032 |
Enzyme and pathway databases
Reactomei | R-GGA-6798695, Neutrophil degranulation R-GGA-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
PROi | PR:Q5ZKU5 |
Gene expression databases
Bgeei | ENSGALG00000001474, Expressed in colon and 13 other tissues |
Family and domain databases
CDDi | cd04122, Rab14, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030702, Rab14 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
PANTHERi | PTHR24073:SF1098, PTHR24073:SF1098, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB14_CHICK | |
Accessioni | Q5ZKU5Primary (citable) accession number: Q5ZKU5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 28, 2006 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 128 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families