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Protein

Adenosine deaminase

Gene

ADA

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity).By similarity

Catalytic activityi

Adenosine + H2O = inosine + NH3.By similarity

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi16Zinc; catalyticBy similarity1
Metal bindingi18Zinc; catalyticBy similarity1
Binding sitei18SubstrateBy similarity1
Binding sitei20SubstrateBy similarity1
Binding sitei185Substrate; via amide nitrogen and carbonyl oxygenBy similarity1
Metal bindingi212Zinc; catalyticBy similarity1
Active sitei215Proton donorBy similarity1
Sitei236Important for catalytic activityBy similarity1
Metal bindingi294Zinc; catalyticBy similarity1
Binding sitei295SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processNucleotide metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

BRENDAi3.5.4.4 1306

Names & Taxonomyi

Protein namesi
Recommended name:
Adenosine deaminase (EC:3.5.4.4By similarity)
Alternative name(s):
Adenosine aminohydrolase
Gene namesi
Name:ADA
ORF Names:RCJMB04_9m8
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Cytoplasmic vesicle, Lysosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001943551 – 357Adenosine deaminaseAdd BLAST357

Proteomic databases

PaxDbiQ5ZKP6

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000006620

Structurei

3D structure databases

ProteinModelPortaliQ5ZKP6
SMRiQ5ZKP6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1097 Eukaryota
COG1816 LUCA
HOGENOMiHOG000218816
HOVERGENiHBG001718
InParanoidiQ5ZKP6
KOiK01488
PhylomeDBiQ5ZKP6

Family and domain databases

CDDicd01320 ADA, 1 hit
HAMAPiMF_00540 A_deaminase, 1 hit
InterProiView protein in InterPro
IPR006650 A/AMP_deam_AS
IPR001365 A/AMP_deaminase_dom
IPR028893 A_deaminase
IPR006330 Ado/ade_deaminase
IPR032466 Metal_Hydrolase
PfamiView protein in Pfam
PF00962 A_deaminase, 1 hit
SUPFAMiSSF51556 SSF51556, 1 hit
TIGRFAMsiTIGR01430 aden_deam, 1 hit
PROSITEiView protein in PROSITE
PS00485 A_DEAMINASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q5ZKP6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERGVRVFGE PKVELHIHLD GAIRPETILH FGKKRGVPLP GSTVDELMKH
60 70 80 90 100
VSYQTPLSLK LFLEKFNHYM PAIAGDREAV RRIAYELVET KAKEGVVYVE
110 120 130 140 150
VRYSPHLLAN CRVEPIPWGQ AEGDLTPEEV VNLVNQGLQD GERNFRIKAR
160 170 180 190 200
SILCCMRHMP SWSPEVVELC KKYQNNSVVA IDLAGDELLM ASSDHKAAYE
210 220 230 240 250
EAERCGIHRT VHAGEAGPAT MIKEAVYLLK AERIGHGYHV LEDPELYREL
260 270 280 290 300
LRTRMHFEVC PWSSYLTGAC LPDFRKHPVV QFKKDQANYS INTDDPLIFN
310 320 330 340 350
SNIDKDYGIV KEYMDFTEED FKRVNINAAQ SSFLPEKEKQ ELLNTLYEAY

GMVPATS
Length:357
Mass (Da):40,679
Last modified:November 23, 2004 - v1
Checksum:i207806303E3FD54E
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F1P2A6F1P2A6_CHICK
Adenosine deaminase
ADA
357Annotation score:
A0A1D5PDK4A0A1D5PDK4_CHICK
Adenosine deaminase
ADA
325Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720038 mRNA Translation: CAG31697.1
RefSeqiNP_001006290.1, NM_001006290.2
UniGeneiGga.9054

Genome annotation databases

GeneIDi419194
KEGGigga:419194

Similar proteinsi

Entry informationi

Entry nameiADA_CHICK
AccessioniPrimary (citable) accession number: Q5ZKP6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 23, 2004
Last modified: July 5, 2017
This is version 78 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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