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Entry version 83 (05 Jun 2019)
Sequence version 2 (16 Aug 2005)
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Protein

pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

Gene

FTSJ3

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.UniRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei56S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei58S-adenosyl-L-methionine; via amide nitrogenUniRule annotation1
Binding sitei76S-adenosyl-L-methionineUniRule annotation1
Binding sitei92S-adenosyl-L-methionineUniRule annotation1
Binding sitei117S-adenosyl-L-methionineUniRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei157Proton acceptorUniRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRibosome biogenesis, rRNA processing
LigandS-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3UniRule annotation (EC:2.1.1.-UniRule annotation)
Alternative name(s):
Protein ftsJ homolog 3UniRule annotation
Putative rRNA methyltransferase 3UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FTSJ3UniRule annotation
ORF Names:RCJMB04_10b6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001555811 – 832pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3Add BLAST832

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5ZKM1

PRoteomics IDEntifications database

More...
PRIDEi
Q5ZKM1

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with NIP7.

UniRule annotation

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000039839

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5ZKM1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili726 – 758UniRule annotationAdd BLAST33

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi338 – 522Glu-richAdd BLAST185

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1098 Eukaryota
COG0293 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162368

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5ZKM1

KEGG Orthology (KO)

More...
KOi
K14857

Database of Orthologous Groups

More...
OrthoDBi
1362679at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5ZKM1

Family and domain databases

HAMAP database of protein families

More...
HAMAPi
MF_01547 RNA_methyltr_E, 1 hit
MF_03163 RNA_methyltr_E_SPB1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR012920 rRNA_MeTfrase_Spb1_C
IPR024576 rRNA_MeTfrase_Spb1_DUF3381
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
IPR028589 Spb1-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11861 DUF3381, 1 hit
PF01728 FtsJ, 1 hit
PF07780 Spb1_C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53335 SSF53335, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5ZKM1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKKSKVGKS RRDKFYHLAK ETGFRSRSAF KLLQLNRKFQ FLQKARALLD
60 70 80 90 100
LCAAPGGWLQ VASKFMPVSS LVIGVDLVPI KPIPNVVTLQ EDITTEKCRQ
110 120 130 140 150
ALRKELQTWK VDVVLNDGAP NVGASWVHDA YSQANLTLMA LKLACEFLCK
160 170 180 190 200
GGWFITKVFR SRDYQPLLWI FQQFFHKVQA TKPQASRNES AEIFVVCQGY
210 220 230 240 250
QAPDKIDSKF FDPKYAFKEV EVHAKSVSEL VSKKKPKAEG YADGDTTLYH
260 270 280 290 300
RFTLMDFLKA PNPVDFLSKA NEITLGDGEL ENHSSTTEEL RQCCKDIRVL
310 320 330 340 350
GRKELRALLN WRTKLRRFLT KKLKEQAKEL DINLSSGEEE EGREEEEKTS
360 370 380 390 400
PKAAADEMVK EEEEEVELAL AEMKAKELAE LKRKKKKILK EQRKQRERVE
410 420 430 440 450
LKMDLPGVSI ADDGDTSMFS LQTIQRTQLL NEVARGDMAS ADALLEMRPG
460 470 480 490 500
DDDICVSDAD DEDDVSLASD LDPEELVEIE ARQRRLERER REQGVKRVKP
510 520 530 540 550
KVEEEEEEEE EEENPLLVPL EEKSVLQERQ TSLWFGKDAF AGIEDDADED
560 570 580 590 600
LELGQSQMLA ERQRESQTGK TKKKGQKKKV PQESTAAEPQ DAADTGADTA
610 620 630 640 650
EAEAEQSSDD DSSSDEEGPP TPVGRKRGLV EPCGFEVVPI EDPVKKARVL
660 670 680 690 700
DAEGLALGSV IATSKKAKRD LIDDSFNRYS FNEEEGELPE WFTEEEKQHR
710 720 730 740 750
RKQIPLDKQT VEEYRQRWRQ INARPIKKVA EAKARKKRRM LKKMEQMKKK
760 770 780 790 800
AEAVVSTVDI SEREKVAQLR RIYKKAGLGK EKRQVTYLVA KKGVGPRVRR
810 820 830
PPGVKGQFKV VDSRLKKDVR AQKRKEQKKR RK
Length:832
Mass (Da):95,006
Last modified:August 16, 2005 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB03A332C19730EA9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAG31722 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1M → V (PubMed:15642098).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ720063 mRNA Translation: CAG31722.1 Different initiation.
AADN02056696 Genomic DNA No translation available.
AADN02061717 Genomic DNA No translation available.
AADN02056695 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001026096.2, NM_001030925.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
419943

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:419943

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720063 mRNA Translation: CAG31722.1 Different initiation.
AADN02056696 Genomic DNA No translation available.
AADN02061717 Genomic DNA No translation available.
AADN02056695 Genomic DNA No translation available.
RefSeqiNP_001026096.2, NM_001030925.2

3D structure databases

SMRiQ5ZKM1
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000039839

Proteomic databases

PaxDbiQ5ZKM1
PRIDEiQ5ZKM1

Genome annotation databases

GeneIDi419943
KEGGigga:419943

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
117246

Phylogenomic databases

eggNOGiKOG1098 Eukaryota
COG0293 LUCA
HOGENOMiHOG000162368
InParanoidiQ5ZKM1
KOiK14857
OrthoDBi1362679at2759
PhylomeDBiQ5ZKM1

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5ZKM1

Family and domain databases

HAMAPiMF_01547 RNA_methyltr_E, 1 hit
MF_03163 RNA_methyltr_E_SPB1, 1 hit
InterProiView protein in InterPro
IPR015507 rRNA-MeTfrase_E
IPR012920 rRNA_MeTfrase_Spb1_C
IPR024576 rRNA_MeTfrase_Spb1_DUF3381
IPR002877 rRNA_MeTrfase_FtsJ_dom
IPR029063 SAM-dependent_MTases
IPR028589 Spb1-like
PfamiView protein in Pfam
PF11861 DUF3381, 1 hit
PF01728 FtsJ, 1 hit
PF07780 Spb1_C, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSPB1_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5ZKM1
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: August 16, 2005
Last modified: June 5, 2019
This is version 83 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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