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Protein

Bromodomain-containing protein 7

Gene

BRD7

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Participates in the Wnt signaling pathway. Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Inhibits cell cycle progression from G1 to S phase (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processCell cycle, Transcription, Transcription regulation, Wnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain-containing protein 7
Gene namesi
Name:BRD7
ORF Names:RCJMB04_11a18
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002276671 – 651Bromodomain-containing protein 7Add BLAST651

Proteomic databases

PaxDbiQ5ZKG2

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000005996

Structurei

3D structure databases

ProteinModelPortaliQ5ZKG2
SMRiQ5ZKG2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini148 – 218BromoPROSITE-ProRule annotationAdd BLAST71

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili533 – 564Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi65 – 96Nuclear localization signalBy similarityAdd BLAST32

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi3 – 91Lys-richAdd BLAST89

Keywords - Domaini

Bromodomain, Coiled coil

Phylogenomic databases

eggNOGiKOG1828 Eukaryota
ENOG410XRRI LUCA
HOGENOMiHOG000070022
HOVERGENiHBG071934
InParanoidiQ5ZKG2
KOiK11723
PhylomeDBiQ5ZKG2

Family and domain databases

Gene3Di1.20.920.10, 1 hit
InterProiView protein in InterPro
IPR001487 Bromodomain
IPR036427 Bromodomain-like_sf
IPR021900 DUF3512
PfamiView protein in Pfam
PF00439 Bromodomain, 1 hit
PF12024 DUF3512, 1 hit
PRINTSiPR00503 BROMODOMAIN
SMARTiView protein in SMART
SM00297 BROMO, 1 hit
SUPFAMiSSF47370 SSF47370, 1 hit
PROSITEiView protein in PROSITE
PS50014 BROMODOMAIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q5ZKG2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKKHKKHKS DKHPYEEYVE KPLKLVLKVG GNEVAELSTG SAGLDSSLYE
60 70 80 90 100
DKSEHEKHKD RKRKKRKKGE KQVPGEEKEK RKRKVKEDKR KRDREHPDSE
110 120 130 140 150
GEQELRCQTP IRLELSPEKP LTSSLSKQEE VEQTPLQEAL NQLMRQLQRK
160 170 180 190 200
DPSSFFSFPV TDFIAPGYSM IIKNPMDFST MKEKIKNNGY QSIEELKDNF
210 220 230 240 250
KLMCTNAMTY NKPDTIYYKA AKKLLHSGMK ILSQERIQSL KQSIEFMADL
260 270 280 290 300
QKTRKQKDKV ELQLSGEDES GSGKDKGEPV DGDTKAFKTP NKEHKKKDKD
310 320 330 340 350
LLEDKLRINS LEREQEQIDR IVRESGGKLT RRLANSQCEF ERRKPDGTTT
360 370 380 390 400
LGLLNPVDLT AGEAGYCPVK LGMTAGRLQS GVNMLQGFKE DKRNKVTPVT
410 420 430 440 450
YLNYGPYSSY APTYDSTFAN ISKEDSDLIY STYGEDSNQG SFSIHEFLMK
460 470 480 490 500
SQDYPFLMAD SLLDVLTKGG HSRSLRELET PLEEDEGPHE RSDALKEIME
510 520 530 540 550
IDIAARLDSA NNDRLTALKA VTNFGMPMEE FDSEEAEIFQ RKLDETTKLL
560 570 580 590 600
RELQDAQNER LSTKPPPNMI CLLGPSYREM HLAERVTNNL KELAQQVTPG
610 620 630 640 650
DIVSTYGIRK AMGISIPLPD IGDSGVDLTD EFQEPKKTVT ITENECGPVT

V
Length:651
Mass (Da):74,022
Last modified:November 23, 2004 - v1
Checksum:i44318F8C16BC1DFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720122 mRNA Translation: CAG31781.1
RefSeqiNP_001005839.1, NM_001005839.1
UniGeneiGga.6338

Genome annotation databases

GeneIDi415730
KEGGigga:415730

Similar proteinsi

Entry informationi

Entry nameiBRD7_CHICK
AccessioniPrimary (citable) accession number: Q5ZKG2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: November 23, 2004
Last modified: October 25, 2017
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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