UniProtKB - Q5ZKB9 (DDX6_CHICK)
Protein
Probable ATP-dependent RNA helicase DDX6
Gene
DDX6
Organism
Gallus gallus (Chicken)
Status
Functioni
Essential for the formation of P-bodies, cytosolic membrane-less ribonucleoprotein granules involved in RNA metabolism through the coordinated storage of mRNAs encoding regulatory functions. Plays a role in P-bodies to coordinate the storage of translationally inactive mRNAs in the cytoplasm and prevent their degradation.By similarity
Catalytic activityi
- EC:3.6.4.13By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 140 – 147 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- mRNA binding Source: GO_Central
- protein domain specific binding Source: Ensembl
- RNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of translation Source: UniProtKB
- P-body assembly Source: UniProtKB
- positive regulation of miRNA mediated inhibition of translation Source: UniProtKB
- stem cell population maintenance Source: Ensembl
- stress granule assembly Source: GO_Central
- viral RNA genome packaging Source: Ensembl
Keywordsi
Molecular function | Helicase, Hydrolase, RNA-binding |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Probable ATP-dependent RNA helicase DDX6 (EC:3.6.4.13By similarity)Alternative name(s): DEAD box protein 6 |
Gene namesi | Name:DDX6 ORF Names:RCJMB04_11n24 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Cytosol
- cytosol Source: Ensembl
Nucleus
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- cytoplasmic stress granule Source: GO_Central
- P-body Source: UniProtKB
- RISC complex Source: Ensembl
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274533 | 1 – 483 | Probable ATP-dependent RNA helicase DDX6Add BLAST | 483 |
Proteomic databases
PaxDbi | Q5ZKB9 |
Interactioni
GO - Molecular functioni
- protein domain specific binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 680837, 1 interactor |
STRINGi | 9031.ENSGALP00000039796 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 127 – 298 | Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST | 172 | |
Domaini | 308 – 468 | Helicase C-terminalPROSITE-ProRule annotationAdd BLAST | 161 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 96 – 124 | Q motifAdd BLAST | 29 | |
Motifi | 246 – 249 | DEAD box | 4 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0326, Eukaryota |
GeneTreei | ENSGT00900000141067 |
InParanoidi | Q5ZKB9 |
OrthoDBi | 583315at2759 |
PhylomeDBi | Q5ZKB9 |
TreeFami | TF300440 |
Family and domain databases
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR000629, RNA-helicase_DEAD-box_CS IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00039, DEAD_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
i Sequence
Sequence statusi: Complete.
Q5ZKB9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTARTENPV IMGLSSQNGQ LRGPVKPSGG PGGGGTQTQQ QMNQLKNANT
60 70 80 90 100
INNGTQQQAQ SMTTTIKPGD DWKKTLKLPP KDLRIKTSDV TSTKGNEFED
110 120 130 140 150
YCLKRELLMG IFEMGWEKPS PIQEESIPIA LSGRDILARA KNGTGKSGAY
160 170 180 190 200
LIPLLERLDL KKDNIQAMVI VPTRELALQV SQICIQVSKH MGGAKVMATT
210 220 230 240 250
GGTNLRDDIM RLDDTVHVVI ATPGRILDLI KKGVAKVEHV QMIVLDEADK
260 270 280 290 300
LLSQDFVQIM EDIILTLPKN RQILLYSATF PLSVQKFMNS HLQKPYEINL
310 320 330 340 350
MEELTLKGVT QYYAYVTERQ KVHCLNTLFS RLQINQSIIF CNSSQRVELL
360 370 380 390 400
AKKISQLGYS CFYIHAKMRQ EHRNRVFHDF RNGLCRNLVC TDLFTRGIDI
410 420 430 440 450
QAVNVVINFD FPKLAETYLH RIGRSGRFGH LGLAINLITY DDRFNLKSIE
460 470 480
EQLGTEIKPI PSNIDKSLYV AEYHSEPVED EKQ
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ720165 mRNA Translation: CAG31824.1 |
RefSeqi | NP_001268976.1, NM_001282047.3 XP_015153490.1, XM_015298004.1 |
Genome annotation databases
Ensembli | ENSGALT00000058124; ENSGALP00000046305; ENSGALG00000033064 ENSGALT00000107898; ENSGALP00000065105; ENSGALG00000033064 |
GeneIDi | 419783 |
KEGGi | gga:419783 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ720165 mRNA Translation: CAG31824.1 |
RefSeqi | NP_001268976.1, NM_001282047.3 XP_015153490.1, XM_015298004.1 |
3D structure databases
SMRi | Q5ZKB9 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 680837, 1 interactor |
STRINGi | 9031.ENSGALP00000039796 |
Proteomic databases
PaxDbi | Q5ZKB9 |
Genome annotation databases
Ensembli | ENSGALT00000058124; ENSGALP00000046305; ENSGALG00000033064 ENSGALT00000107898; ENSGALP00000065105; ENSGALG00000033064 |
GeneIDi | 419783 |
KEGGi | gga:419783 |
Organism-specific databases
CTDi | 1656 |
Phylogenomic databases
eggNOGi | KOG0326, Eukaryota |
GeneTreei | ENSGT00900000141067 |
InParanoidi | Q5ZKB9 |
OrthoDBi | 583315at2759 |
PhylomeDBi | Q5ZKB9 |
TreeFami | TF300440 |
Miscellaneous databases
PROi | PR:Q5ZKB9 |
Family and domain databases
InterProi | View protein in InterPro IPR011545, DEAD/DEAH_box_helicase_dom IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR000629, RNA-helicase_DEAD-box_CS IPR014014, RNA_helicase_DEAD_Q_motif |
Pfami | View protein in Pfam PF00270, DEAD, 1 hit PF00271, Helicase_C, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00039, DEAD_ATP_HELICASE, 1 hit PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit PS51195, Q_MOTIF, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DDX6_CHICK | |
Accessioni | Q5ZKB9Primary (citable) accession number: Q5ZKB9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | November 23, 2004 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families