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Entry version 110 (25 May 2022)
Sequence version 1 (23 Nov 2004)
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Protein

Probable cation-transporting ATPase 13A4

Gene

ATP13A4

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4834-aspartylphosphate intermediateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi845MagnesiumBy similarity1
Metal bindingi849MagnesiumBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTranslocase
LigandATP-binding, Magnesium, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable cation-transporting ATPase 13A4 (EC:7.2.2.-)
Alternative name(s):
P5-ATPase isoform 4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ATP13A4
ORF Names:RCJMB04_11o9
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 32CytoplasmicSequence analysisAdd BLAST32
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei33 – 53HelicalSequence analysisAdd BLAST21
Topological domaini54 – 219ExtracellularSequence analysisAdd BLAST166
Transmembranei220 – 242HelicalSequence analysisAdd BLAST23
Topological domaini243 – 397CytoplasmicSequence analysisAdd BLAST155
Transmembranei398 – 418HelicalSequence analysisAdd BLAST21
Topological domaini419 – 433ExtracellularSequence analysisAdd BLAST15
Transmembranei434 – 454HelicalSequence analysisAdd BLAST21
Topological domaini455 – 897CytoplasmicSequence analysisAdd BLAST443
Transmembranei898 – 918HelicalSequence analysisAdd BLAST21
Topological domaini919 – 929ExtracellularSequence analysisAdd BLAST11
Transmembranei930 – 950HelicalSequence analysisAdd BLAST21
Topological domaini951 – 967CytoplasmicSequence analysisAdd BLAST17
Transmembranei968 – 988HelicalSequence analysisAdd BLAST21
Topological domaini989 – 1043ExtracellularSequence analysisAdd BLAST55
Transmembranei1044 – 1064HelicalSequence analysisAdd BLAST21
Topological domaini1065 – 1075CytoplasmicSequence analysisAdd BLAST11
Transmembranei1076 – 1096HelicalSequence analysisAdd BLAST21
Topological domaini1097 – 1113ExtracellularSequence analysisAdd BLAST17
Transmembranei1114 – 1134HelicalSequence analysisAdd BLAST21
Topological domaini1135 – 1204CytoplasmicSequence analysisAdd BLAST70

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003186771 – 1204Probable cation-transporting ATPase 13A4Add BLAST1204

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q5ZKB7

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9031.ENSGALP00000011610

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q5ZKB7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q5ZKB7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0208, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q5ZKB7

Database of Orthologous Groups

More...
OrthoDBi
172453at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q5ZKB7

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.1110.10, 1 hit
3.40.50.1000, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDF00027, p-type_atpase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00831, Cation_ATPase_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01494, ATPase_P-type, 3 hits
TIGR01657, P-ATPase-V, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q5ZKB7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGENPAKSHY AQLNLGEENE MEIFGYKTQC CRKALCIAGY ILSCGALLLL
60 70 80 90 100
FYWKPEWDVW ANCVPCSLEE ADVVLLRTTD EFRIYSRKNV TWISVSGIIK
110 120 130 140 150
SRLDYPSFAE EDSIFSKALM KPSLQVKSIQ VQKIRYVWNI YAKQFQKVGA
160 170 180 190 200
LEDHHTCSAI HTKFGSGLTC SEQSLRRVIC GPNTIDVPVI PIWKLLIKEV
210 220 230 240 250
LNPFYVFQLF SVCLWFAEDY MEYAAAIIIM SPLSISLTVY DLRQQSVKLQ
260 270 280 290 300
RLVESHNSIM VTGRNKEGFQ ELESHHLVPG DMVVLKEGKA LLPCDAILIS
310 320 330 340 350
GQCIVNESML TGESIPVTKT QLPQADNLKP WKMHCAEDYK KHVLFCGTEV
360 370 380 390 400
IQTKGDDRGV VKAVVLQTGF NTAKGDLVRS ILYPKPMNFR LYRDALRFLM
410 420 430 440 450
CLIAFAAIGM IYTVCVFALN GEEAGEVVKK ALDVITIAVP PALPAALTTG
460 470 480 490 500
IIYTQRRLKK KGIFCISPQR INMCGQLNLI CFDKTGTLTE DGLDLWGLLP
510 520 530 540 550
SEGNCFQDVR RFPADHSLPW GPAFRAMVVC HSLIVLEGKI QGDPLDVKMF
560 570 580 590 600
EATNWVIDDS SGHQIEGQRS THATVIRPGP KANTASVDGI TILHQFPFSS
610 620 630 640 650
ALQRMSVIAQ ETGGEKQAFT KGAPEMVATL CRAETVPSNF ESKLLFYTAQ
660 670 680 690 700
GFRVIGLAYK SLQSGKQSTD LTREEVESDL TFLGLLIMEN RLKRETKPVL
710 720 730 740 750
EELSAAHIRS VMVTGDNIQT AVTVAKNAGM ISPTNRVILV EANKIPGSFS
760 770 780 790 800
ASVTWKPLKE NKTEDDGNLD SGSQTGRRIR LAAEPGQFHF AMSGKSYQVV
810 820 830 840 850
AQYFSHLLPK LLLNATVFAR MSPSQKSSLV EEFQKLDYFV GMCGDGANDC
860 870 880 890 900
GALKVAHAGI SLSEQEASVA SPFTSRTPSI ACVPELIREG RAALVTSFCM
910 920 930 940 950
FKYMALYSTI QYLGVLLLYW QLNSFGNYQF LFQDLAITTV IGMTMSFTEA
960 970 980 990 1000
YPKLVPYRPP SQLVSPPLLL SVILNILFSL GMQILGFLMV QKQPWYSKTD
1010 1020 1030 1040 1050
IHSACLSVNN HVENSSSASS LGLHGVGGGD PTEVDNGYKS YENTTVWLLS
1060 1070 1080 1090 1100
TINCLIIALV FSKGKPFRQP IYTNYVFIMV LVGQLGVCLF LVFADIDDLY
1110 1120 1130 1140 1150
SKMDLVCTPT TWRISMVMML AVTLAVSFLV EEAIIENRAL WLWLKKTFQY
1160 1170 1180 1190 1200
HSKSHYKRLQ RVLEQDSAWP PLNETFSLDA VTVSVEEDME GHSNPTFDSN

EDAL
Length:1,204
Mass (Da):134,058
Last modified:November 23, 2004 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB6AECD6FE30FFDEB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ720167 mRNA Translation: CAG31826.1

NCBI Reference Sequences

More...
RefSeqi
NP_001026485.1, NM_001031314.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
424901

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
gga:424901

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720167 mRNA Translation: CAG31826.1
RefSeqiNP_001026485.1, NM_001031314.1

3D structure databases

AlphaFoldDBiQ5ZKB7
SMRiQ5ZKB7
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000011610

Proteomic databases

PaxDbiQ5ZKB7

Genome annotation databases

GeneIDi424901
KEGGigga:424901

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84239

Phylogenomic databases

eggNOGiKOG0208, Eukaryota
InParanoidiQ5ZKB7
OrthoDBi172453at2759
PhylomeDBiQ5ZKB7

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q5ZKB7

Family and domain databases

Gene3Di3.40.1110.10, 1 hit
3.40.50.1000, 2 hits
InterProiView protein in InterPro
IPR004014, ATPase_P-typ_cation-transptr_N
IPR023299, ATPase_P-typ_cyto_dom_N
IPR018303, ATPase_P-typ_P_site
IPR023298, ATPase_P-typ_TM_dom_sf
IPR008250, ATPase_P-typ_transduc_dom_A_sf
IPR036412, HAD-like_sf
IPR023214, HAD_sf
IPR006544, P-type_TPase_V
IPR001757, P_typ_ATPase
IPR044492, P_typ_ATPase_HD_dom
PfamiView protein in Pfam
PF00690, Cation_ATPase_N, 1 hit
PF12409, P5-ATPase, 1 hit
SFLDiSFLDF00027, p-type_atpase, 1 hit
SMARTiView protein in SMART
SM00831, Cation_ATPase_N, 1 hit
SUPFAMiSSF56784, SSF56784, 1 hit
SSF81653, SSF81653, 1 hit
SSF81660, SSF81660, 1 hit
SSF81665, SSF81665, 1 hit
TIGRFAMsiTIGR01494, ATPase_P-type, 3 hits
TIGR01657, P-ATPase-V, 1 hit
PROSITEiView protein in PROSITE
PS00154, ATPASE_E1_E2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAT134_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q5ZKB7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: November 23, 2004
Last modified: May 25, 2022
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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