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Protein

Eukaryotic translation initiation factor 3 subunit J

Gene

EIF3J

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionInitiation factor
Biological processProtein biosynthesis

Enzyme and pathway databases

ReactomeiR-GGA-72649 Translation initiation complex formation
R-GGA-72689 Formation of a pool of free 40S subunits
R-GGA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-GGA-72702 Ribosomal scanning and start codon recognition

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 3 subunit JUniRule annotation
Short name:
eIF3jUniRule annotation
Alternative name(s):
Eukaryotic translation initiation factor 3 subunit 1UniRule annotation
eIF-3-alphaUniRule annotation
eIF3 p35UniRule annotation
Gene namesi
Name:EIF3JUniRule annotation
Synonyms:EIF3S1UniRule annotation
ORF Names:RCJMB04_12b11
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 10

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003651231 – 252Eukaryotic translation initiation factor 3 subunit JAdd BLAST252

Proteomic databases

PaxDbiQ5ZKA4
PRIDEiQ5ZKA4

Expressioni

Gene expression databases

BgeeiENSGALG00000008187 Expressed in 11 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ5ZKA4 baseline and differential

Interactioni

Subunit structurei

Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.UniRule annotation

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013321

Structurei

3D structure databases

ProteinModelPortaliQ5ZKA4
SMRiQ5ZKA4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili65 – 130UniRule annotationAdd BLAST66

Sequence similaritiesi

Belongs to the eIF-3 subunit J family.UniRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4813 Eukaryota
ENOG4111U5G LUCA
GeneTreeiENSGT00390000018400
HOGENOMiHOG000238746
HOVERGENiHBG066230
InParanoidiQ5ZKA4
KOiK03245
OMAiMPPKKWD
OrthoDBiEOG091G141O
PhylomeDBiQ5ZKA4

Family and domain databases

Gene3Di1.10.246.60, 1 hit
HAMAPiMF_03009 eIF3j, 1 hit
InterProiView protein in InterPro
IPR023194 eIF3-like_dom_sf
IPR013906 eIF3j
PANTHERiPTHR21681 PTHR21681, 1 hit
PfamiView protein in Pfam
PF08597 eIF3_subunit, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q5ZKA4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAEADSWDA DTFEVVEPVA KRLVPAGVAG DRWAGEDEED DVKDNWDDEE
60 70 80 90 100
EEEEVKEAEV KQEPKVSEKK KIAEKIKEKE KQQKKKQEEL KKRLEAPEEH
110 120 130 140 150
KELTPEEQLA DKLRLKKLQE ESDLELAKET FGVNNACGID AMNPSSKDDF
160 170 180 190 200
TEFGKLLKEK ITQYEKSLHY ASFLEALVRD VCISLEIDDL KKITNSLTVL
210 220 230 240 250
CSEKQKQEKQ SKAKKKKKGV VPGGGLKATM KDDLADYGGY DGEYVQEFED

FM
Length:252
Mass (Da):28,724
Last modified:November 23, 2004 - v1
Checksum:iD3614FD629E137DA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1D5PGW1A0A1D5PGW1_CHICK
Eukaryotic translation initiation f...
EIF3J EIF3S1
253Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720180 mRNA Translation: CAG31839.1
RefSeqiNP_001012789.1, NM_001012771.2
UniGeneiGga.1493

Genome annotation databases

EnsembliENSGALT00000013336; ENSGALP00000013321; ENSGALG00000008187
GeneIDi415573
KEGGigga:415573

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ720180 mRNA Translation: CAG31839.1
RefSeqiNP_001012789.1, NM_001012771.2
UniGeneiGga.1493

3D structure databases

ProteinModelPortaliQ5ZKA4
SMRiQ5ZKA4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000013321

Proteomic databases

PaxDbiQ5ZKA4
PRIDEiQ5ZKA4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000013336; ENSGALP00000013321; ENSGALG00000008187
GeneIDi415573
KEGGigga:415573

Organism-specific databases

CTDi8669

Phylogenomic databases

eggNOGiKOG4813 Eukaryota
ENOG4111U5G LUCA
GeneTreeiENSGT00390000018400
HOGENOMiHOG000238746
HOVERGENiHBG066230
InParanoidiQ5ZKA4
KOiK03245
OMAiMPPKKWD
OrthoDBiEOG091G141O
PhylomeDBiQ5ZKA4

Enzyme and pathway databases

ReactomeiR-GGA-72649 Translation initiation complex formation
R-GGA-72689 Formation of a pool of free 40S subunits
R-GGA-72695 Formation of the ternary complex, and subsequently, the 43S complex
R-GGA-72702 Ribosomal scanning and start codon recognition

Miscellaneous databases

PROiPR:Q5ZKA4

Gene expression databases

BgeeiENSGALG00000008187 Expressed in 11 organ(s), highest expression level in skeletal muscle tissue
ExpressionAtlasiQ5ZKA4 baseline and differential

Family and domain databases

Gene3Di1.10.246.60, 1 hit
HAMAPiMF_03009 eIF3j, 1 hit
InterProiView protein in InterPro
IPR023194 eIF3-like_dom_sf
IPR013906 eIF3j
PANTHERiPTHR21681 PTHR21681, 1 hit
PfamiView protein in Pfam
PF08597 eIF3_subunit, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiEIF3J_CHICK
AccessioniPrimary (citable) accession number: Q5ZKA4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 3, 2009
Last sequence update: November 23, 2004
Last modified: October 10, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Translation initiation factors
    List of translation initiation factor entries
  2. SIMILARITY comments
    Index of protein domains and families
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